Epilepsy Research and Treatment / 2016 / Article / Tab 4

Research Article

Prevalence of Different Combinations of Antiepileptic Drugs and CNS Drugs in Elderly Home Care Service and Nursing Home Patients in Norway

Table 4

Other identified drug-drug interactions involving antiepileptic drugs in patients ≥65 years receiving home cares services or living in nursing homes.

Antiepileptic drugs
CarbamazepinePhenobarbitalPhenytoinValproic acidPregabalin or gabapentinTotal
%%%%%

Pharmacokinetic interactions79
 Amlodipine1910.046.323
 Atorvastatin34.83
 Simvastatin3116.4410.335
 Folic acid512.85
 Zopiclone914.3410.313

Pharmacodynamic interactions265
 Benzodiazepines410.34917.653
 Fluoxetine11.11
 Mianserin136.923.225.117
 Opioids69.57928.485
 Zopiclone3116.47828.1109

Other interactions13
 AII-blockers and diuretics136.913

Interactions in total10724191206357

Caused by combination with AED enzyme inducers or inhibitors causing a decrease in serum concentration and lack of efficacy of the affected drug or an increase in serum concentration and excessive adverse effects or toxicity, respectively. With other CNS-active drugs resulting in a possibility for excessive adverse effects and sedation. Increased excretion of sodium and increased risk of hyponatremia with carbamazepine. Also a pharmacokinetic interaction and included in Table 3.

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