Table of Contents
Epilepsy Research and Treatment
Volume 2016 (2016), Article ID 5873208, 4 pages
http://dx.doi.org/10.1155/2016/5873208
Research Article

Ketogenic Diet Decreases Emergency Room Visits and Hospitalizations Related to Epilepsy

1Epilepsy Section, Neurology Division, Department of Pediatrics, Children’s Mercy Hospitals and Clinics, University of Missouri in Kansas City, Kansas City, MO, USA
2Neurology Department, Helen DeVos Children’s Hospital, Grand Rapids, MI, USA

Received 15 July 2016; Accepted 6 September 2016

Academic Editor: József Janszky

Copyright © 2016 Husam R. Kayyali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. A. Hauser and D. H. Hesdorffer, Epilepsy: Frequency, Causes and Consequences, Demos Press, New York, NY, USA, 1990.
  2. P. Kwan and M. J. Brodie, “Early identification of refractory epilepsy,” The New England Journal of Medicine, vol. 342, no. 5, pp. 314–319, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Leonardi and T. B. Ustun, “The global burden of epilepsy,” Epilepsia, vol. 43, supplement 6, pp. 21–25, 2002. View at Google Scholar · View at Scopus
  4. C. E. Begley, M. Famulari, J. F. Annegers et al., “The cost of epilepsy in the United States: an estimate from population-based clinical and survey data,” Epilepsia, vol. 41, no. 3, pp. 342–351, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. C. E. Begley, J. F. Annegers, D. R. Lairson, T. F. Reynolds, and W. A. Hauser, “Cost of epilepsy in the United States: a model based on incidence and prognosis,” Epilepsia, vol. 35, no. 6, pp. 1230–1243, 1994. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Guerrini, R. Battini, A. R. Ferrari et al., “The costs of childhood epilepsy in Italy: comparative findings from three health care settings,” Epilepsia, vol. 42, no. 5, pp. 641–646, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. R. M. Wilder, “The effect of ketonemia on the course of epilepsy,” Mayo Clinic Bulletin, vol. 2, pp. 307–308, 1921. View at Google Scholar
  8. E. H. Kossoff and J. R. McGrogan, “Worldwide use of the ketogenic diet,” Epilepsia, vol. 46, no. 2, pp. 280–289, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. D. L. Keene, “A systematic review of the use of the ketogenic diet in childhood epilepsy,” Pediatric Neurology, vol. 35, no. 1, pp. 1–5, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. C. B. Henderson, F. M. Filloux, S. C. Alder, J. L. Lyon, and D. A. Caplin, “Efficacy of the ketogenic diet as a treatment option for epilepsy: meta-analysis,” Journal of Child Neurology, vol. 21, no. 3, pp. 193–198, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. S.-C. Mak, C.-S. Chi, and C.-J. Wan, “Clinical experience of ketogenic diet on children with refractory epilepsy,” Acta Paediatrica Taiwanica, vol. 40, no. 2, pp. 97–100, 1999. View at Google Scholar · View at Scopus
  12. G. Coppola, P. Veggiotti, R. Cusmai et al., “The ketogenic diet in children, adolescents and young adults with refractory epilepsy: an Italian multicentric experience,” Epilepsy Research, vol. 48, no. 3, pp. 221–227, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. F. Lefevre and N. Aronson, “Ketogenic diet for the treatment of refractory epilepsy in children: a systematic review of efficacy,” Pediatrics, vol. 105, no. 4, article E46, 2000. View at Publisher · View at Google Scholar · View at Scopus
  14. E. G. Neal, H. Chaffe, R. H. Schwartz et al., “The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial,” The Lancet Neurology, vol. 7, no. 6, pp. 500–506, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Hemingway, J. M. Freeman, D. J. Pillas, and P. L. Pyzik, “The ketogenic diet: a 3- to 6-year follow-up of 150 children enrolled prospectively,” Pediatrics, vol. 108, no. 4, pp. 898–905, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. H. C. Kang, Y. J. Kim, D. W. Kim, and H. D. Kim, “Efficacy and safety of the ketogenic diet for intractable childhood epilepsy: Korean multicentric experience,” Epilepsia, vol. 46, no. 2, pp. 272–279, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Mandel, M. Ballew, J. E. Pina-Garza, V. Stalmasek, and L. H. Clemens, “Medical costs are reduced when children with intractable epilepsy are successfully treated with the ketogenic diet,” Journal of the American Dietetic Association, vol. 102, no. 3, pp. 396–398, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. http://www.ninds.nih.gov/disorders/epilepsy/detail_epilepsy.htm.
  19. H. R. Kayyali, M. Gustafson, T. Myers, L. Thompson, M. Williams, and A. Abdelmoity, “Ketogenic diet efficacy in the treatment of intractable epileptic spasms,” Pediatric Neurology, vol. 50, no. 3, pp. 224–227, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. T. A. Hodgson and M. R. Meiners, “Cost-of-illness methodology: a guide to current practices and procedures,” The Milbank Memorial Fund Quarterly. Health and Society, vol. 60, no. 3, pp. 429–462, 1982. View at Publisher · View at Google Scholar · View at Scopus
  21. R. J. A. de Kinderen, D. A. J. E. Lambrechts, D. Postulart et al., “Research into the (Cost-) effectiveness of the ketogenic diet among children and adolescents with intractable epilepsy: design of a randomized controlled trial,” BMC Neurology, vol. 11, article 10, 2011. View at Publisher · View at Google Scholar · View at Scopus