Autosomal Recessive Nonsyndromic Hearing Impairment due to a Novel Deletion in the RDX Gene
Table 1
Two-point and multipoint LOD scores for family 4208 at chromosome 11q22.3-q24.1.
Marker name1
Physical map position2
Genetic map position3
Multipoint LOD score
Two-point LOD score at θ =
0.0
0.01
0.05
0.10
0.20
0.30
D11S2371
73,182,778
84.41
−∞
−∞
−0.35
0.24
0.37
0.31
0.15
D11S2002
79,643,050
91.48
−13.66
−∞
−1.41
−0.18
0.20
0.33
0.22
D11S2000
105,063,887
111.71
−6.18
−6.08
−0.15
0.90
1.07
0.83
0.42
D11S1391
110,200,327
115.14
5.20
3.18
3.10
2.74
2.29
1.43
0.68
D11S1998
117,202,969
126.24
5.78
4.47
4.36
3.95
3.41
2.33
1.26
D11S4464
123,131,592
136.99
−∞
−∞
−2.84
−0.93
−0.25
0.16
0.17
D11S912
128,129,301
145.13
−∞
−∞
−1.52
−0.62
−0.25
0.01
0.06
D11S968
133,323,584
160.10
−4.03
−1.95
−0.06
0.54
0.64
0.45
0.18
1Markers in bold denote marker limits based on the 3-unit support interval and the homozygous region. 2Physical map positions in base pairs from Build 36 of the human reference sequence. 3Genetic map positions in cM from Rutgers combined linkage-physical map of the human genome Build 36 version.