Inactivation of the X-linked FMR1 gene leads to the loss of its encoded protein FMRP and RNA export factor NXF2, causing defects in neuronal development and function as well as in male germ cells.
Associated with poor prognosis of diverse cancer types
Catalyses the deubiquitylation of histone H2B and is required for appropriate cell-cycle progression. Component of the 11-gene polycomb/cancer stem-cell signature