The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency

Figure 2

Structural detail of Tat•P-TEFb interaction. The two panels depict surface (upper) and cartoon (lower) representations of the crystal structure of the complex between HIV Tat and P-TEFb. Tat is full length 86 amino acid protein, but only residues 1–49 are visible. Cdk9 (dark green) is a 1-345 truncation of the 372 amino acid protein. Cyclin T1 (light green) is a 1–266 truncation of the 726 amino acid protein. The two zinc atoms coordinated by the interface of Tat and cyclin T1 are indicated as yellow spheres. ATP (magenta) and Mg (blue) are shown bound to the active site of Cdk9. The figure was created using Pymol from PDB entry 3MIA [34].