Review Article

Control of Transcriptional Elongation by RNA Polymerase II: A Retrospective

Figure 1

RNA pol II density profile across a typical metazoan protein-coding gene. Elevated density around the transcription start site (TSS) results from promoter-proximal pausing and possibly premature termination of transcription. Blue and green arrows denote divergent transcription from the TSS. A second peak of pol II accumulation downstream of the poly (A) site precedes termination coupled to cleavage/polyadenylation. Black arrows denote termination of transcription with eviction of pol II (yellow circles) from the DNA template downstream of the poly (A) site (red arrow) and possibly also in the promoter-proximal region. The mRNA cap structure is denoted by a white circle.
170173.fig.001