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Genetics Research International
Volume 2012, Article ID 648207, 10 pages
Review Article

Notch Signaling during Oogenesis in Drosophila melanogaster

1The Jackson Laboratory, Bar Harbor, ME 04609, USA
2Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA
3Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA

Received 29 February 2012; Accepted 19 April 2012

Academic Editor: Robert E. Ferrell

Copyright © 2012 Jingxia Xu and Thomas Gridley. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism that is required for embryonic development, cell fate specification, and stem cell maintenance. Discovered and studied initially in Drosophila melanogaster, the Notch pathway is conserved and functionally active throughout the animal kingdom. In this paper, we summarize the biochemical mechanisms of Notch signaling and describe its role in regulating one particular developmental pathway, oogenesis in Drosophila.