Genetics Research International / 2012 / Article / Tab 3

Review Article

Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications

Table 3

Involvement of lncRNAs in lung cancer and technologies used for identification.

lncRNASignificanceTechnologySource tissueReference

Overexpression of MALAT1Predict metastasis and survival in early-stage NSCLCSubtractive hybridization method, sequencing and quantitative RT-PCRShock frozen primary nonsmall cell lung tumors[15]
Deregulated expression of BC200Detectable at significant levels in tumors.
Normal tissue from the same patient was found to be BC200-negative
In situ hybridizationTumour and normal tissue frozen in liquid nitrogen[87]
Overexpression of H19Loss of imprinting in lung adenocarcinomaRT-PCRLC tissue and normal lung[176]

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