TY - JOUR A2 - Del Castillo, Ignacio AU - Celis-Aguilar, Erika AU - Lassaletta, Luis AU - Torres-Martín, Miguel AU - Rodrigues, F. Yuri AU - Nistal, Manuel AU - Castresana, Javier S. AU - Gavilan, Javier AU - Rey, Juan A. PY - 2012 DA - 2012/02/20 TI - The Molecular Biology of Vestibular Schwannomas and Its Association with Hearing Loss: A Review SP - 856157 VL - 2012 AB - Hearing loss is the most common symptom in patients with vestibular schwannoma (VS). In the past, compressive mechanisms caused by the tumoral mass and its growth have been regarded as the most likely causes of the hearing loss associated with VS. Interestingly, new evidence proposes molecular mechanisms as an explanation for such hearing loss. Among the molecular mechanisms proposed are methylation of TP73, negative expression of cyclin D1, expression of B7-H1, increased expression of the platelet-derived growth factor A, underexpression of PEX5L, RAD54B, and PSMAL, and overexpression of CEA. Many molecular mechanisms are involved in vestibular schwannoma development; we review some of these mechanisms with special emphasis on hearing loss associated with vestibular schwannoma. SN - 2090-3154 UR - https://doi.org/10.1155/2012/856157 DO - 10.1155/2012/856157 JF - Genetics Research International PB - Hindawi Publishing Corporation KW - ER -