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Genetics Research International
Volume 2012, Article ID 856157, 10 pages
http://dx.doi.org/10.1155/2012/856157
Review Article

The Molecular Biology of Vestibular Schwannomas and Its Association with Hearing Loss: A Review

1Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez, 14269 Ciudad de México, DF, Mexico
2Department of Otolaryngology, “La Paz” University Hospital, 28046 Madrid, Spain
3Unidad de Investigación, Laboratorio Oncogenetica Molecular, “La Paz” University Hospital, 28046 Madrid, Spain
4Department of Pathology, “La Paz” University Hospital, 28046 Madrid, Spain
5Brain Tumor Biology Unit, CIFA, University of Navarra School of Sciences, 31009 Pamplona, Spain

Received 2 June 2011; Revised 8 October 2011; Accepted 3 November 2011

Academic Editor: Ignacio Del Castillo

Copyright © 2012 Erika Celis-Aguilar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hearing loss is the most common symptom in patients with vestibular schwannoma (VS). In the past, compressive mechanisms caused by the tumoral mass and its growth have been regarded as the most likely causes of the hearing loss associated with VS. Interestingly, new evidence proposes molecular mechanisms as an explanation for such hearing loss. Among the molecular mechanisms proposed are methylation of TP73, negative expression of cyclin D1, expression of B7-H1, increased expression of the platelet-derived growth factor A, underexpression of PEX5L, RAD54B, and PSMAL, and overexpression of CEA. Many molecular mechanisms are involved in vestibular schwannoma development; we review some of these mechanisms with special emphasis on hearing loss associated with vestibular schwannoma.