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Genetics Research International
Volume 2013, Article ID 852080, 12 pages
http://dx.doi.org/10.1155/2013/852080
Review Article

Epigenetics in Friedreich's Ataxia: Challenges and Opportunities for Therapy

Division of Biosciences, School of Health Sciences and Social Care, Brunel University London, Uxbridge UB8 3PH, UK

Received 3 October 2012; Accepted 10 January 2013

Academic Editor: Rajith N. De Silva

Copyright © 2013 Chiranjeevi Sandi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [14 citations]

The following is the list of published articles that have cited the current article.

  • Pierre Chapdelaine, Zoé Coulombe, Amina Chikh, Catherine Gérard, and Jacques P Tremblay, “A Potential New Therapeutic Approach for Friedreich Ataxia: Induction of Frataxin Expression With TALE Proteins,” Molecular Therapy—Nucleic Acids, vol. 2, no. 9, pp. e119, 2013. View at Publisher · View at Google Scholar
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  • Aurélien Bayot, and Pierre Rustin, “Friedreich's Ataxia, Frataxin, PIP5K1B: Echo of a Distant Fracas,” Oxidative Medicine and Cellular Longevity, vol. 2013, pp. 1–7, 2013. View at Publisher · View at Google Scholar
  • Chiranjeevi Sandi, Sahar Al-Mahdawi, Ricardo Mouro Pinto, and Mark A. Pook, “Friedreich Ataxia Patient Tissues Exhibit Increased 5-Hydroxymethylcytosine Modification and Decreased CTCF Binding at the FXN Locus,” Plos One, vol. 8, no. 9, 2013. View at Publisher · View at Google Scholar
  • Chiranjeevi Sandi, Madhavi Sandi, Sara Anjomani Virmouni, Sahar Al-Mahdawi, and Mark A. Pook, “Epigenetic-based therapies for Friedreich ataxia,” Frontiers in Genetics, vol. 5, 2014. View at Publisher · View at Google Scholar
  • A. Anzovino, D. J. R. Lane, and M. L-H Huang, “Fixing frataxin: 'ironing out' the metabolic defect in Friedreich's ataxia,” British Journal of Pharmacology, vol. 171, no. 8, pp. 2174–2190, 2014. View at Publisher · View at Google Scholar
  • Chiranjeevi Sandi, Madhavi Sandi, Harvinder Jassal, Vahid Ezzatizadeh, Sara Anjomani-Virmouni, Sahar Al-Mahdawi, and Mark A. Pook, “Generation and Characterisation of Friedreich Ataxia YG8R Mouse Fibroblast and Neural Stem Cell Models,” Plos One, vol. 9, no. 2, 2014. View at Publisher · View at Google Scholar
  • Tommaso Vannocci, Nathalie Faggianelli, Silvia Zaccagnino, Ilaria della Rosa, Salvatore Adinolfi, and Annalisa Pastore, “A new cellular model to follow Friedreich's ataxia development in a time-resolved way,” Disease Models & Mechanisms, vol. 8, no. 7, pp. 711–719, 2015. View at Publisher · View at Google Scholar
  • Sara Anjomani Virmouni, Vahid Ezzatizadeh, Chiranjeevi Sandi, Madhavi Sandi, Sahar Al-Mahdawi, Yogesh Chutake, and Mark A. Pook, “A novel GAA-repeat-expansion-based mouse model of Friedreich's ataxia,” Disease Models & Mechanisms, vol. 8, no. 3, pp. 225–235, 2015. View at Publisher · View at Google Scholar
  • Charles J. Isaacs, Julianna E. Shinnick, Kimberly Schadt, David R. Lynch, and Kimberly Y. Lin, “Prospects of gene and cell therapy for managing cardiac complications in Friedreich ataxia,” Expert Opinion On Orphan Drugs, vol. 3, no. 10, pp. 1183–1196, 2015. View at Publisher · View at Google Scholar
  • Shashikanta Tarai, Arindam Bit, Helton José dos Reis, András Palotás, Albert Rizvanov, and Akalabya Bissoyi, “Stratifying Heterogeneous Dimension of Neurodegenerative Diseases: Intervention for Stipulating Epigenetic Factors to Combat Oxidative Stress in Human Brain,” BioNanoScience, 2016. View at Publisher · View at Google Scholar
  • H Khonsari, M Schneider, S Al-Mahdawi, Y G Chianea, M Themis, C Parris, M A Pook, and M Themis, “Lentivirus-meditated frataxin gene delivery reverses genome instability in Friedreich ataxia patient and mouse model fibroblasts.,” Gene therapy, vol. 23, no. 12, pp. 846–856, 2016. View at Publisher · View at Google Scholar
  • Tommaso Vannocci, Roberto Notario Manzano, Ombretta Beccalli, Barbara Bettegazzi, Fabio Grohovaz, Gianfelice Cinque, Antonio de Riso, Luca Quaroni, Franca Codazzi, and Annalisa Pastore, “Adding a temporal dimension to the study of Friedreich's ataxia: the effect of frataxin overexpression in a human cell model,” Disease Models & Mechanisms, vol. 11, no. 6, pp. dmm032706, 2018. View at Publisher · View at Google Scholar