Genetics Research International

Research Article

Power Estimation for Gene-Longevity Association Analysis Using Concordant Twins

Table 1

Power estimates for additive effects using longevity concordant MZ twins.
Relative risk90+95+
100200300500800100200300500800
MAF = 0.05          
 0.50.95 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.46 0.78 0.90 0.99 1.00 0.94 1.00 1.00 1.00 1.00
 0.80.21 0.40 0.53 0.75 0.92 0.54 0.84 0.95 1.00 1.00
 0.850.13 0.22 0.32 0.49 0.69 0.31 0.58 0.72 0.93 0.99
 0.90.09 0.12 0.17 0.23 0.34 0.14 0.29 0.35 0.59 0.74
 0.950.06 0.06 0.08 0.10 0.13 0.06 0.10 0.12 0.19 0.25
MAF = 0.1          
 0.51.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.73 0.95 0.99 1.00 1.00 0.99 1.00 1.00 1.00 1.00
 0.80.37 0.62 0.80 0.96 1.00 0.80 0.98 1.00 1.00 1.00
 0.850.21 0.39 0.52 0.76 0.92 0.51 0.83 0.94 0.99 1.00
 0.90.11 0.19 0.27 0.41 0.56 0.25 0.44 0.59 0.81 0.96
 0.950.06 0.07 0.11 0.13 0.19 0.08 0.14 0.17 0.30 0.38
MAF = 0.2          
 0.51.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.92 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.80.58 0.87 0.96 1.00 1.00 0.96 1.00 1.00 1.00 1.00
 0.850.34 0.61 0.77 0.94 0.99 0.78 0.96 1.00 1.00 1.00
 0.90.19 0.32 0.42 0.61 0.81 0.43 0.66 0.84 0.96 1.00
 0.950.09 0.09 0.13 0.21 0.30 0.13 0.20 0.29 0.46 0.62
MAF = 0.5          
 0.51.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.98 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.80.74 0.96 0.99 1.00 1.00 0.99 1.00 1.00 1.00 1.00
 0.850.48 0.79 0.91 0.99 1.00 0.87 0.99 1.00 1.00 1.00
 0.90.22 0.43 0.57 0.81 0.95 0.53 0.82 0.95 1.00 1.00
 0.950.08 0.13 0.17 0.25 0.41 0.16 0.30 0.40 0.61 0.82
Power estimates over the lines are acceptable.