Research Article
Power Estimation for Gene-Longevity Association Analysis Using Concordant Twins
Table 3
Power estimates for recessive effects using longevity concordant MZ twins.
| Relative risk | 90+ | 95+ | 100 | 200 | 300 | 500 | 800 | 100 | 200 | 300 | 500 | 800 |
| MAF = 0.05 | | | | | | | | | | | 0.5 | — | 0.07 | 0.15 | 0.26 | 0.41 | 0.15 | 0.47 | 0.66 | 0.87 | 0.99 | 0.7 | — | — | 0.05 | 0.10 | 0.12 | — | 0.06 | 0.15 | 0.26 | 0.38 | 0.8 | — | — | — | — | 0.08 | — | — | — | 0.10 | 0.13 | 0.85 | — | — | — | — | 0.07 | — | — | — | 0.07 | 0.10 | 0.9 | — | — | — | — | 0.06 | — | — | — | — | 0.08 | 0.95 | — | — | — | — | — | — | — | — | — | 0.05 | MAF = 0.1 | | | | | | | | | | | 0.5 | 0.25 | 0.48 | 0.70 | 0.88 | 0.98 | 0.85 | 1.00 | 1.00 | 1.00 | 1.00 | 0.7 | 0.07 | 0.13 | 0.20 | 0.31 | 0.47 | 0.18 | 0.40 | 0.57 | 0.81 | 0.96 | 0.8 | — | 0.08 | 0.10 | 0.12 | 0.19 | 0.09 | 0.13 | 0.23 | 0.31 | 0.52 | 0.85 | — | 0.06 | 0.08 | 0.09 | 0.12 | — | 0.11 | 0.11 | 0.18 | 0.30 | 0.9 | — | 0.05 | 0.05 | 0.05 | 0.07 | — | 0.07 | 0.08 | 0.08 | 0.15 | 0.95 | — | — | 0.05 | — | 0.06 | — | 0.05 | — | 0.07 | 0.08 | MAF = 0.2 | | | | | | | | | | | 0.5 | 0.90 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.7 | 0.29 | 0.50 | 0.68 | 0.88 | 0.98 | 0.75 | 0.96 | 1.00 | 1.00 | 1.00 | 0.8 | 0.13 | 0.20 | 0.29 | 0.45 | 0.66 | 0.32 | 0.55 | 0.75 | 0.91 | 0.98 | 0.85 | 0.08 | 0.12 | 0.17 | 0.26 | 0.38 | 0.17 | 0.31 | 0.40 | 0.63 | 0.85 | 0.9 | 0.06 | 0.07 | 0.10 | 0.13 | 0.18 | 0.08 | 0.15 | 0.17 | 0.26 | 0.41 | 0.95 | 0.05 | 0.06 | 0.07 | 0.06 | 0.09 | 0.05 | 0.09 | 0.08 | 0.08 | 0.12 | MAF = 0.5 | | | | | | | | | | | 0.5 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.7 | 0.92 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.8 | 0.51 | 0.77 | 0.91 | 0.99 | 1.00 | 0.90 | 1.00 | 1.00 | 1.00 | 1.00 | 0.85 | 0.28 | 0.47 | 0.65 | 0.87 | 0.97 | 0.63 | 0.89 | 0.98 | 1.00 | 1.00 | 0.9 | 0.14 | 0.22 | 0.31 | 0.45 | 0.64 | 0.26 | 0.50 | 0.68 | 0.87 | 0.98 | 0.95 | 0.06 | 0.08 | 0.11 | 0.14 | 0.19 | 0.09 | 0.16 | 0.20 | 0.30 | 0.46 |
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Power estimates over the lines are acceptable.
bDashes indicate power estimates <0.05.
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