Genetics Research International / 2014 / Article / Tab 5

Research Article

Power Estimation for Gene-Longevity Association Analysis Using Concordant Twins

Table 5

Power estimates for dominant effects using longevity concordant DZ twins.

Relative risk90+95+
10020030050080015001002003005008001500

MAF = 0.05
 0.50.72 0.93 0.99 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.28 0.47 0.65 0.85 0.97 1.00 0.64 0.91 0.99 1.00 1.00 1.00
 0.80.15 0.24 0.32 0.48 0.68 0.92 0.32 0.56 0.72 0.91 0.99 1.00
 0.850.10 0.16 0.16 0.28 0.40 0.66 0.20 0.34 0.45 0.63 0.84 0.98
 0.90.07 0.08 0.12 0.14 0.20 0.34 0.12 0.16 0.21 0.33 0.49 0.75
 0.950.05 0.06 0.05 0.07 0.09 0.12 0.07 0.07 0.08 0.11 0.14 0.24
MAF = 0.1
 0.50.88 0.99 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.44 0.71 0.84 0.98 1.00 1.00 0.85 0.99 1.00 1.00 1.00 1.00
 0.80.18 0.37 0.49 0.69 0.88 0.99 0.49 0.76 0.91 0.98 1.00 1.00
 0.850.12 0.19 0.30 0.47 0.63 0.88 0.28 0.51 0.69 0.88 0.98 1.00
 0.90.09 0.14 0.15 0.22 0.33 0.55 0.15 0.23 0.35 0.51 0.70 0.92
 0.950.06 0.05 0.06 0.07 0.11 0.16 0.07 0.09 0.10 0.15 0.22 0.36
MAF = 0.2
 0.50.97 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.58 0.84 0.95 1.00 1.00 1.00 0.94 1.00 1.00 1.00 1.00 1.00
 0.80.28 0.50 0.65 0.86 0.96 1.00 0.64 0.90 0.98 1.00 1.00 1.00
 0.850.17 0.29 0.36 0.58 0.80 0.97 0.41 0.62 0.80 0.95 0.99 1.00
 0.90.12 0.14 0.21 0.28 0.43 0.69 0.19 0.31 0.47 0.65 0.84 0.98
 0.950.06 0.07 0.08 0.10 0.11 0.20 0.08 0.10 0.15 0.21 0.31 0.51
MAF = 0.5
 0.50.95 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.46 0.77 0.90 0.98 1.00 1.00 0.84 0.98 1.00 1.00 1.00 1.00
 0.80.25 0.41 0.54 0.76 0.91 1.00 0.46 0.73 0.89 0.99 1.00 1.00
 0.850.15 0.24 0.34 0.49 0.69 0.90 0.28 0.49 0.65 0.86 0.98 1.00
 0.90.08 0.12 0.16 0.25 0.35 0.58 0.14 0.25 0.32 0.54 0.70 0.93
 0.950.05 0.07 0.08 0.09 0.13 0.17 0.06 0.10 0.11 0.17 0.24 0.40

Power estimates over the lines are acceptable.