Genetics Research International / 2014 / Article / Tab 6

Research Article

Power Estimation for Gene-Longevity Association Analysis Using Concordant Twins

Table 6

Power estimates for recessive effects using longevity concordant DZ twins.

Relative risk90+95+
10020030050080015001002003005008001500

MAF = 0.05
 0.50.070.130.190.320.14 0.26 0.42 0.60 0.89
 0.70.050.080.090.05 0.11 0.15 0.28
 0.80.060.070.06 0.09 0.12
 0.850.050.070.06 0.07
 0.90.05 0.05
 0.950.050.05
MAF = 0.1
 0.50.110.180.320.460.680.910.45 0.73 0.91 0.99 1.00 1.00
 0.70.050.070.090.130.230.360.08 0.17 0.25 0.36 0.57 0.83
 0.80.060.070.090.110.160.07 0.09 0.15 0.26 0.41
 0.850.050.060.060.090.090.07 0.09 0.11 0.14 0.24
 0.90.060.060.090.05 0.06 0.08 0.10
 0.950.050.050.050.050.05 0.06 0.06
MAF = 0.2
 0.50.51 0.77 0.92 0.99 1.00 1.00 0.99 1.00 1.00 1.00 1.00 1.00
 0.70.14 0.23 0.36 0.51 0.73 0.93 0.38 0.62 0.82 0.95 1.00 1.00
 0.80.08 0.12 0.16 0.21 0.33 0.57 0.14 0.24 0.34 0.56 0.76 0.96
 0.850.07 0.10 0.15 0.18 0.30 0.08 0.14 0.19 0.30 0.46 0.71
 0.90.06 0.06 0.08 0.07 0.11 0.13 0.06 0.08 0.12 0.14 0.20 0.35
 0.950.05 0.05 0.05 0.05 0.08 0.05 0.06 0.06 0.08 0.08 0.10
MAF = 0.5
 0.51.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.68 0.90 0.99 1.00 1.00 1.00 0.98 1.00 1.00 1.00 1.00 1.00
 0.80.28 0.49 0.65 0.86 0.96 1.00 0.64 0.90 0.98 1.00 1.00 1.00
 0.850.16 0.26 0.38 0.57 0.75 0.95 0.35 0.62 0.78 0.94 0.99 1.00
 0.90.09 0.12 0.20 0.27 0.39 0.62 0.16 0.27 0.38 0.56 0.76 0.97
 0.950.07 0.07 0.08 0.09 0.12 0.17 0.08 0.09 0.12 0.18 0.27 0.44

Power estimates over the lines are acceptable.
bDashes indicate power estimates <0.05.