Modulation at Age of Onset in Tunisian Huntington Disease Patients: Implication of New Modifier Genes

Table 3

Linear regression analysis of polymorphisms in candidate genes affecting the age at onset of Huntington disease in Tunisian patients (in addition to the contribution of the expanded CAG repeat (HD CAG)).

Gene (polymorphism)			% unexplained variability	value
HD CAG	0.745	—	—	0.000*
HD CAG + normal CAG	0.789	0.044	17.18	0.000*
HD CAG + DRPLA (CAG)	0.793	0.048	18.75	0.000*
HD CAG + DMPK (CTG)	0.750	0.005	1.95	0.000*
HD CAG + ATXN1 (CAG)	0.782	0.037	14.45	0.000*
HD CAG + TBP (CAG)	0.747	0.002	0.78	0.001*
HD CAG + JPH3 (CTG)	0.774	0.029	11.32	0.000*
HD CAG + TCERG1 (Gln-Ala)	0.746	0.001	0.39	0.001*
HD CAG + GRIN2A (rs1969060)	0.748	0.003	1.17	0.000*
HD CAG + GRIN2B (rs890)	0.765	0.020	7.81	0.000*

.
Variance in AO for the CAG repeats is indicated as well as in combination with the different examined polymorphisms. illustrates the relative improvement of the regression model when the various genotypes are considered in addition to the HD CAG repeats. values quantify these differences. value refers to .