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Genetics Research International
Volume 2015, Article ID 820323, 5 pages
Research Article

Genetic Variant in the CYP19A1 Gene Associated with Coronary Artery Disease

1Department of Genetics and Biotechnology, Faculty of Biology, University of Athens, 15784 Athens, Greece
2Department of Cardiology, General Hospital “KAT”, 14561 Athens, Greece

Received 26 November 2014; Revised 25 February 2015; Accepted 5 March 2015

Academic Editor: Francine Durocher

Copyright © 2015 Konstantina Bampali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The CYP19A1 gene encodes the enzyme aromatase, which is responsible for the biosynthesis of estrogens. The rs10046 polymorphism of CYP19A1 gene has been investigated in two studies on the occurrence of hypertension, but there are no studies on its correlation with coronary artery disease (CAD). We investigated 189 subjects who were hospitalized at “KAT” General Hospital of Athens and underwent coronary angiography. Of these, 123 were found with CAD with an average age of 60 years and constituted the patients group and 66 subjects with an average age of 58 years without damage in the coronary vessels and constituted the control group (healthy). The frequencies of genotypes CC, CT, and TT of rs10046 polymorphism are significantly different between the group of CAD patients and the control group (0.34, 0.48, and 0.18 versus 0.20, 0.48, and 0.32, resp., ) as the frequency of C allele (0.58 versus 0.44, resp., OR = 1.771 and ). We found similar results for men, but not for women (small sample). The results of this study show that the rs10046 (C/T) polymorphism of CYP19A1 gene exhibits correlation with CAD and that patients with C allele have an increased probability of manifesting the disease.