Genetic Variants in CSMD1 Gene Are Associated with Cognitive Performance in Normal Elderly Population

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Genotype</td><td class="align_center"><span style="width: 11.0475ptpx;"><svg height="8.8423pt" id="M12" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 11.0475 8.8423" width="11.0475pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M822 650H589L583 622C660 617 677 607 674 561C672 534 664 481 647 390L600 137H596L273 650H126L120 622C176 620 194 615 207 594C221 571 225 557 214 504L161 257C141 166 129 112 121 85C108 42 83 30 29 28L23 0H260L266 28C193 33 173 42 176 89C178 122 186 172 202 255L256 527H259L583 -8H612L690 390C708 481 720 535 728 558C744 603 756 619 816 622L822 650Z" id="g113-79"></path></g></svg></span></td><td class="align_center">MoCA mean</td><td class="align_center">MoCA std. deviation</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_center" colspan="4">rs1050325, <span class="nowrap"><svg height="8.8423pt" id="M13" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 50.9722 8.8423" width="50.9722pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M584 650H137L131 622C214 614 217 612 200 521L125 127C109 41 101 35 23 28L17 0H288L294 28C201 35 193 42 209 128L242 309H348C440 309 442 300 443 226H471L510 422H482C452 354 449 348 357 348H251L295 575C302 609 304 615 338 615H426C502 615 517 604 526 581C534 560 536 524 537 492L565 494C574 554 583 631 584 650Z" id="g113-71"></path></g><g transform="matrix(.013,0,0,-0.013,11.527,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z" id="g117-34"></path></g><g transform="matrix(.013,0,0,-0.013,22.79,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 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class="align_center">3.747744</td></tr><tr><td class="align_left">AA</td><td class="align_center">57</td><td class="align_center">22.35088</td><td class="align_center">3.319269</td></tr><tr><td class="align_left">CC</td><td class="align_center">370</td><td class="align_center">22.14595</td><td class="align_center">4.159463</td></tr><tr><td class="align_left">All</td><td class="align_center">674</td><td class="align_center">22.14095</td><td class="align_center">3.942305</td></tr><tr><td class="align_left" colspan="4"><hr/></td></tr><tr><td class="align_center" colspan="4">rs2616984, <span class="nowrap"><svg height="8.8423pt" id="M15" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 50.9722 8.8423" width="50.9722pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M584 650H137L131 622C214 614 217 612 200 521L125 127C109 41 101 35 23 28L17 0H288L294 28C201 35 193 42 209 128L242 309H348C440 309 442 300 443 226H471L510 422H482C452 354 449 348 357 348H251L295 575C302 609 304 615 338 615H426C502 615 517 604 526 581C534 560 536 524 537 492L565 494C574 554 583 631 584 650Z" id="g113-71"></path></g><g transform="matrix(.013,0,0,-0.013,11.527,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z" id="g117-34"></path></g><g transform="matrix(.013,0,0,-0.013,22.79,0)"><path d="M412 140C382 77 369 73 315 73H129L270 222C362 320 402 379 402 466C402 571 322 635 234 635C177 635 130 609 99 576L42 495L64 475C90 514 133 568 201 568C274 568 318 519 318 435C318 349 255 267 193 193C144 135 87 78 32 23V0H405C417 45 427 89 440 131L412 140Z" id="g113-51"></path></g><g transform="matrix(.013,0,0,-0.013,29.03,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z" id="g113-47"></path></g><g transform="matrix(.013,0,0,-0.013,31.994,0)"><path d="M249 635C141 635 70 555 70 471C70 401 114 353 179 316C143 294 106 267 90 252C68 231 45 202 45 157C45 50 130 -12 237 -12C322 -12 435 52 435 169C435 256 372 304 303 343C349 374 375 398 383 407C401 429 411 458 411 487C411 569 344 635 249 635ZM238 603C285 603 337 567 337 482C337 422 310 385 276 358C205 393 145 426 145 500C145 552 179 603 238 603ZM248 20C183 20 125 70 125 163C125 218 158 268 206 300C284 261 355 217 355 143C355 66 308 20 248 20Z" id="g113-57"></path></g><g transform="matrix(.013,0,0,-0.013,38.234,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z" id="g113-50"></path></g><g transform="matrix(.013,0,0,-0.013,44.474,0)"><path d="M456 178V225H360V632H320C217 496 115 347 20 206V178H280V106C280 40 276 34 189 27V0H445V27C364 34 360 39 360 106V178H456ZM280 225H82C149 335 214 431 278 520H280V225Z" id="g113-53"></path></g></svg>,</span> <svg height="11.7782pt" id="M16" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 50.7895 11.7782" width="50.7895pt" 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viewbox="-0.0498162 -8.6359 50.9722 8.8423" width="50.9722pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M584 650H137L131 622C214 614 217 612 200 521L125 127C109 41 101 35 23 28L17 0H288L294 28C201 35 193 42 209 128L242 309H348C440 309 442 300 443 226H471L510 422H482C452 354 449 348 357 348H251L295 575C302 609 304 615 338 615H426C502 615 517 604 526 581C534 560 536 524 537 492L565 494C574 554 583 631 584 650Z" id="g113-71"></path></g><g transform="matrix(.013,0,0,-0.013,11.527,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z" id="g117-34"></path></g><g transform="matrix(.013,0,0,-0.013,22.79,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path></g><g transform="matrix(.013,0,0,-0.013,29.03,0)"><path d="M113 -12C146 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class="align_center">3.655281</td></tr><tr><td class="align_left">CC/AA</td><td class="align_center">198</td><td class="align_center">21.77273</td><td class="align_center">4.239512</td></tr><tr><td class="align_left">AA/AG</td><td class="align_center">16</td><td class="align_center">22.25000</td><td class="align_center">3.193744</td></tr><tr><td class="align_left">CA/AG</td><td class="align_center">100</td><td class="align_center">22.55000</td><td class="align_center">3.957795</td></tr><tr><td class="align_left">CC/AG</td><td class="align_center">139</td><td class="align_center">22.62590</td><td class="align_center">4.005926</td></tr><tr><td class="align_left">AA/GG</td><td class="align_center">3</td><td class="align_center">23.00000</td><td class="align_center">2.645751</td></tr><tr><td class="align_left">CA/GG</td><td class="align_center">21</td><td class="align_center">22.14286</td><td class="align_center">3.119066</td></tr><tr><td class="align_left">CC/GG</td><td class="align_center">33</td><td class="align_center">22.36364</td><td class="align_center">4.211726</td></tr><tr><td class="align_left">All</td><td class="align_center">673</td><td class="align_center">22.14562</td><td class="align_center">3.943373</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

One-way ANOVA analysis of MoCA scores among genotypes of genetic variants in CSMD1 gene.

Genetics Research International

tab4

Table 4

Table 4: Genetic Variants in CSMD1 Gene Are Associated with Cognitive Performance in Normal Elderly Population 