Does i-T744C P2Y12 Polymorphism Modulate Clopidogrel Response among Moroccan Acute Coronary Syndromes Patients?

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Genotypes</td><td class="align_center" colspan="2">EHW cases</td><td class="align_center" colspan="2">EHW controls</td></tr><tr class="thead"><td class="align_center"><svg height="15.2296pt" id="M7" style="vertical-align:-3.6382pt" version="1.1" viewbox="-0.0498162 -11.5914 12.6404 15.2296" width="12.6404pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M565 434L556 448L482 423L322 189L287 373C280 410 261 448 236 448C207 448 161 415 110 338L131 317C160 355 181 374 193 374C204 374 208 366 217 330C230 279 247 185 259 116L50 -175C18 -223 29 -260 41 -278H51C97 -198 207 -33 270 57L313 -165C328 -235 349 -261 376 -261S445 -244 510 -150L487 -127C444 -178 423 -186 411 -186C402 -186 398 -177 387 -130C371 -62 349 39 332 135C390 217 524 392 565 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horiz-adv-x="487" vert-adv-y="487"></glyph.data></g></svg> square</td><td class="align_center"><svg height="8.68572pt" id="M11" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 8.15071 8.68572" width="8.15071pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z" id="g113-81"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="617" vert-adv-y="617"></glyph.data></g></svg> value (<svg height="9.2729pt" id="M12" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 44.8393 9.2729" width="44.8393pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z" id="g113-81"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="617" vert-adv-y="617"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,11.658,0)"><path d="M512 230V281L75 514V456L453 256V254L75 55V-3L512 230Z" id="g117-92"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,22.921,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,29.161,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z" id="g113-47"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="228" vert-adv-y="228"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,32.125,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,38.365,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z" id="g113-54"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg>)</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">i-T744C P2Y12 (rs2046934)</td><td class="align_center">1.35</td><td class="align_center"><span style="width: 28.7269ptpx;"><svg height="10.335pt" id="M13" style="vertical-align:-0.2325001pt" version="1.1" viewbox="-0.0498162 -10.1025 28.7269 10.335" width="28.7269pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M252 635C85 635 28 460 28 311C28 167 82 -12 250 -12C419 -12 472 166 472 312C472 457 419 635 252 635ZM248 594C314 594 335 455 335 314C335 174 318 29 252 29S165 180 165 315S181 594 248 594Z" id="g13-46"></path><glyph.data ascent="1024" descent="-360" horiz-adv-x="500" vert-adv-y="500"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,6.5,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z" id="g113-47"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="228" vert-adv-y="228"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,9.464,0)"><path d="M152 515H407L439 613L433 623H115L70 303C91 310 134 322 179 322C270 322 327 264 327 174C327 100 297 45 235 45C178 45 130 84 106 106C93 117 82 120 70 112C53 99 38 76 38 61S43 36 63 20C84 2 126 -12 166 -12C226 -11 297 15 354 56C424 105 455 164 455 226C455 312 382 394 254 394C228 394 175 380 125 362L152 515Z" id="g13-51"></path><glyph.data ascent="1024" descent="-360" horiz-adv-x="500" vert-adv-y="500"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,15.964,0)"><path d="M409 0V34C329 39 322 56 322 125V635C234 611 160 593 94 583V554L145 551C186 547 190 541 190 488V125C190 54 181 39 102 34V0H409Z" id="g13-47"></path><glyph.data ascent="1024" descent="-360" horiz-adv-x="500" vert-adv-y="500"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,22.548,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 324 179 321 236C368 205 390 186 422 144C444 143 470 148 486 158Z" id="g50-43"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="611" vert-adv-y="611"></glyph.data></g></svg></span></td><td class="align_center">4.26</td><td class="align_center"><span style="width: 28.7269ptpx;"><svg height="10.335pt" id="M14" style="vertical-align:-0.2325001pt" version="1.1" viewbox="-0.0498162 -10.1025 28.7269 10.335" width="28.7269pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M252 635C85 635 28 460 28 311C28 167 82 -12 250 -12C419 -12 472 166 472 312C472 457 419 635 252 635ZM248 594C314 594 335 455 335 314C335 174 318 29 252 29S165 180 165 315S181 594 248 594Z" id="g13-46"></path><glyph.data ascent="1024" descent="-360" horiz-adv-x="500" vert-adv-y="500"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,6.5,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z" id="g113-47"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="228" vert-adv-y="228"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,9.464,0)"><path d="M409 0V34C329 39 322 56 322 125V635C234 611 160 593 94 583V554L145 551C186 547 190 541 190 488V125C190 54 181 39 102 34V0H409Z" id="g13-47"></path><glyph.data ascent="1024" descent="-360" horiz-adv-x="500" vert-adv-y="500"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,15.964,0)"><path d="M306 382C339 403 362 417 379 433C398 450 411 473 411 500C411 578 352 635 248 635H247C181 635 134 604 106 573L56 506L82 482C117 529 151 557 201 557C246 557 287 531 287 466C287 404 228 364 143 336L150 302C165 306 186 309 204 309C258 309 324 275 324 179C324 85 285 44 235 44C175 44 128 88 106 108C92 118 80 116 69 106C56 97 39 79 39 61C39 47 46 34 63 21C83 5 123 -12 174 -12C236 -12 454 58 454 222C454 297 403 362 306 380V382Z" id="g13-49"></path><glyph.data ascent="1024" descent="-360" horiz-adv-x="500" vert-adv-y="500"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,22.548,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 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366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 324 179 321 236C368 205 390 186 422 144C444 143 470 148 486 158Z" id="g50-43"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="611" vert-adv-y="611"></glyph.data></g></svg>Statistically significant.<br/></td></tr></table>

Genetics Research International

tab1

Table 1

Table 1: Does i-T744C P2Y12 Polymorphism Modulate Clopidogrel Response among Moroccan Acute Coronary Syndromes Patients? 