Prevalence of Some Genetic Risk Factors for Nicotine Dependence in Ukraine
Table 2
Genotype frequencies at the biallelic polymorphic loci in Ukraine and the European populations analyzed in 1000 Genomes project.
Gene, SNP
Genotype
Ukraine, (%)
Central Europe, (%)
Finland, (%)
Great Britain, (%)
Spain, (%)
Italy, (%)
DNMT3B rs910083
AA
50 (29.4%)
34 (34.3%)
30 (30.3%)
28 (30.8%)
45 (42.1%)
37 (34.6%)
AC
87 (51.2%)
48 (48.5%)
42 (42.4%)
41 (45.1%)
48 (44.9%)
57 (53.3%)
CC
33 (19.4%)
17 (17.2%)
27 (27.3%)
22 (24.2%)
14 (13.1%)
13 (12.1%)
χ2 -value
0.375
0.307
0.211
0.0014
0.0121
HWE -value
0.907
1
0.325
0.663
0.978
0.452
DRD2 rs1800497
CC
111 (65.3%)
64 (64.6%)
70 (70.7%)
57 (62.6%)
79 (73.8%)
67 (62.6%)
CT
51 (30.0%)
30 (30.3%)
25 (25.3%)
30 (33.0%)
25 (23.4%)
33 (30.8%)
TT
8 (4.7%)
5 (5.1%)
4 (4.0%)
4 (4.4%)
3 (2.8%)
7 (6.5%)
χ2 -value
0.972
0.300
0.712
0.029
0.574
HWE-value
0.795
0.836
0.664
0.9998
0.841
0.584
HTR2A rs6313
CC
55 (39.0%)
27 (27.3%)
40 (40.4%)
40 (44.0%)
35 (32.7%)
24 (22.4%)
CT
70 (49.6%)
54 (54.5%)
44 (44.4%)
36 (39.6%)
43 (40.2%)
58 (54.2%)
TT
16 (11.3%)
18 (18.2%)
15 (15.2%)
15 (16.5%)
29 (27.1%)
25 (23.4%)
χ2 -value
0.0307
0.184
0.0066
1.15 × 10−4
2.97 × 10−5
HWE-value
0.548
0.610
0.881
0.388
0.134
0.684
COMT rs4680
AA
34 (26.4%)
23 (23.2%)
36 (36.4%)
26 (28.6%)
27 (25.2%)
21 (19.6%)
AG
62 (48.0%)
46 (46.5%)
45 (45.5%)
44 (48.4%)
47 (43.9%)
55 (51.4%)
GG
33 (25.6%)
30 (30.3%)
18 (18.2%)
21 (23.1%)
33 (30.8%)
31 (29.0%)
χ2 -value
0.458
0.022
0.752
0.423
0.152
HWE-value
0.908
0.806
0.838
0.960
0.470
0.929
BDNF rs6265
AA
2 (1.2%)
3 (3.0%)
1 (1.0%)
1 (1.1%)
7 (6.5%)
6 (5.6%)
AG
39 (23.1%)
33 (33.3%)
31 (31.3%)
28 (30.8%)
31 (29.0%)
39 (36.4%)
GG
128 (75.7%)
63 (63.6%)
67 (67.7%)
62 (68.1%)
69 (64.5%)
62 (57.9%)
χ2 -value
0.0038
0.0696
0.0953
0.0017
8.17 × 10−6
HWE-value
0.878
0.867
0.449
0.533
0.418
0.999
GABRA2 rs279858
AA
52 (30.4%)
28 (28.3%)
32 (32.3%)
25 (27.5%)
32 (29.9%)
46 (43.0%)
AG
78 (45.6%)
47 (47.5%)
53 (53.5%)
44 (48.4%)
59 (55.1%)
46 (43.0%)
GG
41 (24.0%)
24 (24.2%)
14 (14.1%)
22 (24.2%)
16 (15.0%)
15 (14.0%)
χ2 -value
0.819
9.63 × 10−4
0.670
0.0023
8.83 × 10−5
HWE-value
0.548
0.888
0.566
0.955
0.416
0.817
CHRNA5 rs16969968
AA
20 (11.8%)
15 (15.2%)
8 (8.1%)
7 (7.7%)
22 (20.6%)
18 (16.8%)
AG
74 (43.5%)
46 (46.5%)
44 (44.4%)
37 (40.7%)
57 (53.3%)
44 (41.1%)
GG
76 (44.7%)
38 (38.4%)
47 (47.5%)
47 (51.6%)
28 (26.2%)
45 (42.1%)
χ2 -value
0.185
1.25 × 10−30
1.18 × 10−10
1.52 × 10−27
6.71 × 10−34
HWE-value
0.954
0.985
0.566
0.955
0.955
0.817
Significant right-tail -values () for χ2 statistics are marked in bold. χ2 -value, right-tail -values for χ2 statistics. HWE -value, -values for Hardy–Weinberg equation.
