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Gastroenterology Research and Practice
Volume 2009, Article ID 285830, 9 pages
http://dx.doi.org/10.1155/2009/285830
Research Article

Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal Adenocarcinomas

1Faculty Division Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, Norway
2Department of Surgery, Akershus University Hospital, 1478 Loerenskog, Norway
3EpiGen, Faculty Division Akershus University Hospital, University of Oslo, 1478 Loerenskog, Norway
4Department of Pathology, Akershus University Hospital, 1478 Loerenskog, Norway
5Department of Health Promotion, Akershus University Hospital, 1478 Loerenskog, Norway

Received 22 June 2009; Accepted 23 September 2009

Academic Editor: Bjørn Moum

Copyright © 2009 Rolf Aamodt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Adenocarcinomas of rectum and colon may be different with regard to the cellular biological basis for cancer development. A material of 246 rectal cancers removed surgically at Akershus University Hospital in the years 1992–2000 was investigated and was compared to a material of 219 colon cancers operated on at Akershus University Hospital during the years 1988, 1990 and 1997–2000. There were highly significant differences between the rectal and the colon cancers in the protein expression of cyclin D1, cyclin D3, cyclin E, nuclear -catenin, and c-Myc and in gene amplification of cyclin A2, cyclin B1, cyclin D1, and cyclin E. Gene amplification and protein expression in the rectal cancers correlated significantly for the cyclins B1, D3, and E. A statistically significant relation was observed between overexpression of cyclin A2 and local relapse of rectal carcinomas, as higher expression of cyclin A2 was associated with lower local recurrence rate.