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Gastroenterology Research and Practice
Volume 2009 (2009), Article ID 579501, 4 pages
Case Report

Ileocecal Intussusception with Histomorphological Features of Inflammatory Neuropathy in Adenovirus Infection

1Department of Pediatrics, RWTH Aachen University, 52074 Aachen, Germany
2Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany
3Department of Surgery, RWTH Aachen University, 52074 Aachen, Germany
4Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany

Received 23 June 2009; Revised 8 November 2009; Accepted 16 December 2009

Academic Editor: Alfred Gangl

Copyright © 2009 Elke Kaemmerer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The pathophysiological mechanisms for ileocecal intussusception in children with adenovirus infection are not well characterized. Here we demonstrate coincidence of adenovirus infection and inflammatory neuropathy of myenteric plexus in two children with ileocecal intussusception. Inflammatory neuropathy, an unspecific morphological feature which is found in peristalsis disorders, was morphologically characterized by the influx of CD3 positive lymphocytes in nervous plexus. To our knowledge, this is the first report suggesting peristalsis disorders from inflammatory neuropathy as additional mechanism in the pathophysiological concept of adenovirus-associated ileocecal intussusception.