Ileocecal Intussusception with Histomorphological Features of Inflammatory Neuropathy in Adenovirus Infection
Morphological aspects of ileocecal surgical specimens with intussusception; (a)–(d) Patient 1 (adenovirus infection); (e) Patient 2 (adenovirus infection); (f) Patient 3 (no adenovirus infection). (a) Ileocecal specimen with polypoid intraluminal tumour nodules (arrowhead). The appendix is marked by an arrow. Barr indicates 1 cm. (b) Transmural tissue section of the terminal ileum displaying lymphoid hyperplasia with diffuse lymphocytic infiltration. H/E; original magnification 50. (c) Dense lymphocytic infiltrates in strong vicinity to nervous plexus with ganglia (arrowheads). Lymphocytes accumulate in subserosal connective tissues. H/E; original magnification 200. (d) Anti-CD3 immunohistochemistry demonstrates T-lymphocytes in strong vicinity to the intramural plexus cells (plexus border is marked by dotted line). Small vessels crossing the plexus are marked with arrowheads. Original magnification 400. (e) Tissue section of the terminal ileum (patient 2) demonstrates the plexus myentericus (dotted line) and several infiltrating lymphocytes and eosinophiles (arrowheads). H/E; original magnification 400. (f) Transmural ileal tissue section (patient 3, adenovirus negative intussusception) with only mild lymphoid hyperplasia and few infiltrating lymphocytes (the nervous plexus is marked by arrowheads). Inset: Strong accumulation of erythrocytes adjacent to the nervous plexus (dotted line), but morphological features of inflammatory neuropathy are not visible. H/E; original magnification 50; inset 400.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.