Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2: Effects on Intestinal Morphology and Absorption, Renal Function, Bone and Body Composition, and Muscle Function

Table 3

Diet, feces, absorption (diet-feces), and urine excretion of wet weight, sodium, potassium, calcium, and magnesium.

(mean ± SD, 𝑛=8)	1st year				2nd year
	Baseline	Week 13	Week 26	Week 52	Washout	Week 13	Week 26	Week 52	𝑃-value*
Treatment	None	GLP-2	GLP-2	GLP-2	None	GLP-2	GLP-2 + Cholyl-sarcosine#	GLP-2
Wet weight (g/d)
Diet	4680±1945	4232±1813§	4069±1523§	3768±1355§	4228±1589§	3779±1254§	3905±1293§	3623±1047§	.03
Feces	2995±1905	2136±1388§	2366±391§	2048±1158§	2759±1371	1853±1093§	2094±1139§	1794±771§	<.001
Abs. absorption	1686±578	2096±600	1702±784	1720±506	1468±627	1926±854	1811±679	1929±656	.11
Rel. absorption	39±16	52±13§	41±16	48±14	35±17	52±18§	47±18	50±15	<.001
Urine	1407±860	1740±756	1720±749	1635±774	1410±807	1855±1002	1528±917	1551±596	.16
Sodium (mmol/d)
Diet	238±116	233±126	228±117	209±118	223±109	222±113	203±101	216±104	.41
Feces	264±132	197±113§	234±96§	203±96§	250±150	198±108§	226±119§	195±79§	.001
Abs. absorption	−26±84	36±64	−6±89	6±71	−27±126	25±74	−23±96	21±61	.06
Rel. absorption	−24±72	13±29	−25±81	−18±74	−27±78	−8±92	−32±95	−2±55	.15
Urine	77±139	139±80§	133±50§	122±55§	59±72	124±64§	78±61	100±66	.001
Potassium (mmol/d)
Diet	117±45	107±43§	111±38§	100±43§	104±43§	93±34§	90±26§	90±24§	.007
Feces	49±41	32±31§	31±28§	28±24§	46±30	24±21§	26±23§	23±22§	<.001
Abs. absorption	68±43	76±37	80±28	73±36	58±38	70±36	64±30	67±26	.21
Rel. absorption	58±24	72±28	74±19§	72±24	56±30	73±28	72±25	75±22§	<.001
Urine	62±16	73±13	86±25§	73±19	49±16	87±19§	64±24	86±20§	<.001
Calcium (mmol/d)
Diet	49±30	44±27	42±20	34±20§	39±28§	32±19§	31±18§	32±20§	<.001
Feces	66±52	65±42	70±41	61±42	63±43	50±31§	49±32§	45±24§	<.001
Abs. absorption	−17±35	−21±26	−28±27§	−27±28§	−25±25§	−18±20	−18±26	−13±20	.009
Rel. absorption	−39±59	−55±60	−72±63	−89±82	−87±76	−69±60	−77±112	−66±85	.24
Urine	3±3	3±3	4±4	4±4	4±4	5±4	5±4	4±3	.08
Magnesium (mmol/d)
Diet	19±8	18±8	19±7	17±7§	18±7	16±6§	16±5§	15±4§	.03
Feces	32±27	31±32	34±33	33±35	34±30	29±27	28±25	30±29	.01
Abs. absorption	−12±21	−12±25	−15±27	−16±28	−16±25	−13±23	−12±22	−15±26	.10
Rel. absorption	−51±80	−42±89	−60±92	−67±99	−73±105	−61±108	−60±119	−79±128	.17
Urine	2±2	3±3§	4±3§	4±4§	3±3§	5±3§	4±2§	4±2§	.001

*Friedman repeated measures analysis of variance on ranks in patients completing the study. For comparisons of admission periods to the baseline period, the Dunnett method was used as the post hoc test. §∼𝑃<.05. #Cholylsarcosine was given two days prior to the admission and during the 72-hour balance studies.