Gastroenterology Research and Practice / 2010 / Article / Fig 1

Review Article

LPS-Toll-Like Receptor-Mediated Signaling on Expression of Protein S and C4b-Binding Protein in the Liver

Figure 1

Blood coagulation pathway and protein C anticoagulant pathway. Thrombin, bound to thrombomodulin (TM), activates protein C which binds to endothelial protein C receptor (EPCR). Activated protein C (APC) inactivates coagulation factor Va (Va) and factor VIIIa (VIIIa) in the presence of protein S (PS). PS circulates in free form and in complex with C4b-binding protein (C4BP) in plasma, and the free form of PS plays a role as a cofactor of APC. TF: Tissue factor, PL: Phospholipids.
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