LPS-Toll-Like Receptor-Mediated Signaling on Expression  of Protein S and C4b-Binding Protein in the Liver

<table><i>Blood coagulation pathway and protein C anticoagulant pathway</i>. Thrombin, bound to thrombomodulin (TM), activates protein C which binds to endothelial protein C receptor (EPCR). Activated protein C (APC) inactivates coagulation factor Va (Va) and factor VIIIa (VIIIa) in the presence of protein S (PS). PS circulates in free form and in complex with C4b-binding protein (C4BP) in plasma, and the free form of PS plays a role as a cofactor of APC. TF: Tissue factor, PL: Phospholipids.</table>

Gastroenterology Research and Practice

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Figure 1

Figure 1: LPS-Toll-Like Receptor-Mediated Signaling on Expression  of Protein S and C4b-Binding Protein in the Liver 