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Gastroenterology Research and Practice
Volume 2010 (2010), Article ID 212563, 11 pages
TLR4 and Insulin Resistance
1Department of Pediatrics, University of California, San Diego, CA 92093-0673, USA
2Rady Children's Hospital, San Diego, CA 92093-0673, USA
3Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0673, USA
Received 21 April 2010; Accepted 24 June 2010
Academic Editor: Ekihiro Seki
Copyright © 2010 Jane J. Kim and Dorothy D. Sears. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [50 citations]
The following is the list of published articles that have cited the current article.
- Ahmed Abu-Shanab, and Eamonn M. M. Quigley, “The role of the gut microbiota in nonalcoholic fatty liver disease,” Nature Reviews Gastroenterology & Hepatology, vol. 7, no. 12, pp. 691–701, 2010.
- J. N. Fain, “Correlative studies on the effects of obesity, diabetes and hypertension on gene expression in omental adipose tissue of obese women,” Nutrition & Diabetes, vol. 1, 2011.
- José Augusto Nogueira-Machado, Caroline Maria de Oliveira Volpe, Clara Araujo Veloso, and Miriam Martins Chaves, “HMGB1, TLR and RAGE: a functional tripod that leads to diabetic inflammation,” Expert Opinion on Therapeutic Targets, vol. 15, no. 8, pp. 1023–1035, 2011.
- A. C. Manolakis, A. N. Kapsoritakis, E. K. Tiaka, A. Sidiropoulos, A. Gerovassili, M. Satra, D. Vamvakopoulou, F. Tsiopoulos, N. Papanas, I. Skoularigis, S. P. Potamianos, and N. Vamvakopoulos, “TLR4 gene polymorphisms: evidence for protection against type 2 diabetes but not for diabetes-associated ischaemic heart disease,” European Journal Of Endocrinology, vol. 165, no. 2, pp. 261–267, 2011.
- Manuel Fresno, Ruth Alvarez, and Natalia Cuesta, “Toll-like receptors, inflammation, metabolism and obesity,” Archives of Physiology and Biochemistry, vol. 117, no. 3, pp. 151–164, 2011.
- Sarah A. Robertson, Peck Yin Chin, Danielle J. Glynn, and Jeremy G. Thompson, “Peri-Conceptual Cytokines - Setting the Trajectory for Embryo Implantation, Pregnancy and Beyond,” American Journal of Reproductive Immunology, vol. 66, pp. 2–10, 2011.
- Sungsoon Fang, Jae Myoung Suh, Annette R. Atkins, Suk-Hyun Hong, Mathias Leblanc, Russell R. Nofsinger, Ruth T. Yu, Michael Downes, and Ronald M. Evans, “Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 8, pp. 3412–3417, 2011.
- Riccardina Tesse, Maximilian Schieck, and Michael Kabesch, “Asthma and endocrine disorders: Shared mechanisms and genetic pleiotropy,” Molecular and Cellular Endocrinology, vol. 333, no. 2, pp. 103–111, 2011.
- Devadoss J. Samuvel, Junfei Jin, Kamala P. Sundararaj, Yanchun Li, Xiaoming Zhang, Maria F. Lopes-Virella, and Yan Huang, “TLR4 Activation and IL-6-Mediated Cross Talk between Adipocytes and Mononuclear Cells Synergistically Stimulate MMP-1 Expression,” Endocrinology, vol. 152, no. 12, pp. 4662–4671, 2011.
- Mariana H. Garcia-Hernandez, Liliana Portales-Cervantes, Nancy Cortez-Espinosa, Juan M. Vargas-Morales, Juan F. Fritche Salazar, Emmanuel Rivera-Lopez, Javier G. Rodriguez-Rivera, Roberto Quezada-Calvillo, and Diana P. Portales-Perez, “Expression and function of P2X(7) receptor and CD39/Entpd1 in patients with type 2 diabetes and their association with biochemical parameters,” Cellular Immunology, vol. 269, no. 2, pp. 135–143, 2011.
- Rebeca Garcia-Macedo, Carmen Maldonado-Bernal, Miguel Cruz, Angeles Fortis, and Francisco Alarcon-Aguilar, “The role of innate immunity in obesity,” Salud Publica De Mexico, vol. 54, no. 2, pp. 171–177, 2012.
- Ekihiro Seki, and Bernd Schnabl, “Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut,” Journal Of Physiology-London, vol. 590, no. 3, pp. 447–458, 2012.
- Han-Qiang Liu, Ya Qiu, Ying Mu, Xian-Jiao Zhang, Lu Liu, Xiang-Hong Hou, Lei Zhang, Xiao-Na Xu, Ai-Ling Ji, Rui Cao, Rui-Hua Yang, and Feng Wang, “A high ratio of dietary n-3/n-6 polyunsaturated fatty acids improves obesity-linked inflammation and insulin resistance through suppressing activation of TLR4 in SD rats,” Nutrition Research, 2013.
- Ruchi Mathur, Gene Kim, Walter Morales, Jaekyu Sung, Emily Rooks, Venkata Pokkunuri, Stacy Weitsman, Gillian M. Barlow, Christopher Chang, and Mark Pimentel, “ Intestinal Methanobrevibacter smithii but not total bacteria is related to diet-induced weight gain in rats ,” Obesity, vol. 21, no. 4, pp. 748–754, 2013.
- Anastassios C. Manolakis, Andreas N. Kapsoritakis, Anastasia Kapsoritaki, Elisavet K. Tiaka, Konstantinos A. Oikonomou, Vassilis Lotis, Dimitra Vamvakopoulou, Ioanna Davidi, Nikolaos Vamvakopoulos, and Spyros P. Potamianos, “Readressing the Role of Toll-Like Receptor-4 Alleles in Inflammatory Bowel Disease: Colitis, Smoking, and Seroreactivity,” Digestive Diseases And Sciences, vol. 58, no. 2, pp. 371–380, 2013.
- Jamille Silveira Fernandes Chamon, Fernanda Sarmento Fagundes-Netto, Raquel Miranda Gonzaga, Pollyanna Stephanie Gomes, Caroline Maria de Oliveira Volpe, and José Augusto Nogueira-Machado, “Absence of pyruvate anti-oxidant effect on granulocytes stimulated toll-like receptors,” Free Radicals and Antioxidants, 2013.
- M. Lin, and S. C. W. Tang, “Toll-like receptors: sensing and reacting to diabetic injury in the kidney,” Nephrology Dialysis Transplantation, 2013.
- Ran Meng, Dalong Zhu, Yan Bi, Donghui Yang, and Yaping Wang, “Erythropoietin Inhibits Gluconeogenesis and Inflammation in the Liver and Improves Glucose Intolerance in High-Fat Diet-Fed Mice,” Plos One, vol. 8, no. 1, 2013.
- Wei Fan, Koichi Nakazawa, Shinya Abe, Miori Inoue, Masanobu Kitagawa, Noriyuki Nagahara, and Koshi Makita, “Inhaled aerosolized insulin ameliorates hyperglycemia-induced inflammatory responses in the lungs in an experimental model of acute lung injury,” Critical Care, vol. 17, no. 2, 2013.
- M. Levin, S. -O. Olofsson, and M. -R. Taskinen, “Ectopic lipid storage and insulin resistance: a harmful relationship,” Journal Of Internal Medicine, vol. 274, no. 1, pp. 25–40, 2013.
- Gillian M. Barlow, Mark Pimentel, Jaekyu Sung, Venkata Pokkunuri, Stacy Weitsman, Ruchi Mathur, Walter Morales, Emily Rooks, Christopher Chang, and Gene Kim, “Intestinal Methanobrevibacter smithii but Not Total Bacteria is Related to Diet-Induced Weight Gain in Rats,” Obesity, vol. 21, no. 4, pp. 748–754, 2013.
- Amanda J Cox, Nicholas P West, and Allan W Cripps, “Obesity, inflammation, and the gut microbiota,” The Lancet Diabetes & Endocrinology, 2014.
- Catherine J. Andersen, Ji-Young Lee, Christopher N. Blesso, Timothy P. Carr, and Maria Luz Fernandez, “Egg Intake during Carbohydrate Restriction Alters Peripheral Blood Mononuclear Cell Inflammation and Cholesterol Homeostasis in Metabolic Syndrome,” Nutrients, vol. 6, no. 7, pp. 2650–2667, 2014.
- Aline Corado Gomes, Allain Amador Bueno, Ravila Graziany Machado de Souza, and Joao Felipe Mota, “Gut microbiota, probiotics and diabetes,” Nutrition Journal, vol. 13, 2014.
- M. Remely, E. Aumueller, D. Jahn, B. Hippe, H. Brath, and A. G. Haslberger, “Microbiota and epigenetic regulation of inflammatory mediators in type 2 diabetes and obesity,” Beneficial Microbes, vol. 5, no. 1, pp. 33–43, 2014.
- Kohei Uchimura, Manabu Hayata, Teruhiko Mizumoto, Yoshikazu Miyasato, Yutaka Kakizoe, Jun Morinaga, Tomoaki Onoue, Rika Yamazoe, Miki Ueda, Masataka Adachi, Taku Miyoshi, Naoki Shiraishi, Wataru Ogawa, Kazuki Fukuda, Tatsuya Kondo, Takeshi Matsumura, Eiichi Araki, Kimio Tomita, and Kenichiro Kitamura, “The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling,” Nature Communications, vol. 5, 2014.
- Wai Han Yiu, Miao Lin, and Sydney C W Tang, “Toll-like receptor activation: from renal inflammation to fibrosis,” Kidney International Supplements, vol. 4, no. 1, pp. 20–25, 2014.
- Connie W. Y. Ha, Yan Y. Lam, and Andrew J. Holmes, “Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health,” World Journal Of Gastroenterology, vol. 20, no. 44, pp. 16498–16517, 2014.
- Noha M. Shawky, George S. G. Shehatou, Mona Abdel Rahim, Ghada M. Suddek, and Nariman M. Gameil, “Levocetirizine ameliorates high fructose diet-induced insulin resistance, vascular dysfunction and hepatic steatosis in rats,” European Journal of Pharmacology, vol. 740, pp. 353–363, 2014.
- Kim-Tiu Teng, Chee-Yan Chang, Lin Faun Chang, and Kalanithi Nesaretnam, “Modulation of obesity-induced inflammation by dietary fats: mechanisms and clinical evidence,” Nutrition Journal, vol. 13, 2014.
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- Muthukumaran Jayachandran, Balaji Chandrasekaran, and Nalini Namasiyayam, “Geraniol attenuates fibrosis and exerts anti-inflammatory effects on diet induced atherogenesis by NF-kappa B signaling pathway,” European Journal Of Pharmacology, vol. 762, pp. 102–111, 2015.
- Robert Caesar, Valentina Tremaroli, Petia Kovatcheva-Datchary, Patrice D. Cani, and Fredrik Bäckhed, “Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling,” Cell Metabolism, 2015.
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- Elizabeth Rendina-Ruedy, Jennifer L. Graef, McKale R. Davis, Kelsey D. Hembree, Jeffrey M. Gimble, Stephen L. Clarke, Edralin A. Lucas, and Brenda J. Smith, “Strain differences in the attenuation of bone accrual in a young growing mouse model of insulin resistance,” Journal of Bone and Mineral Metabolism, 2015.
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- A. Singh, G. Boden, and A. K. Rao, “Tissue factor and Toll-like receptor (TLR)4 in hyperglycaemia-hyperinsulinaemia,” Thrombosis and Haemostasis, vol. 113, no. 4, pp. 750–758, 2015.
- Jayshree Mishra, Raj K. Verma, Gianfranco Alpini, Fanyin Meng, and Narendra Kumar, “Role of Janus Kinase 3 in Predisposition to Obesity-associated Metabolic Syndrome,” Journal Of Biological Chemistry, vol. 290, no. 49, pp. 29301–29312, 2015.
- Ariel M. Johnson, Stephanie P. Kurti, Joshua R. Smith, Sara K. Rosenkranz, and Craig A. Harms, “Effects of an acute bout of moderate-intensity exercise on postprandial lipemia and airway inflammation,” Applied Physiology, Nutrition, and Metabolism, pp. 1–8, 2015.
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- Mauricio Krause, Thiago Gomes Heck, Aline Bittencourt, Sofia Pizzato Scomazzon, Philip Newsholme, Rui Curi, and Paulo Ivo Homem de Bittencourt, “The Chaperone Balance Hypothesis: The Importance of the Extracellular to Intracellular HSP70 Ratio to Inflammation-Driven Type 2 Diabetes, the Effect of Exercise, and the Implications for Clinical Management,” Mediators of Inflammation, vol. 2015, pp. 1–12, 2015.
- Shoulong Deng, Kun Yu, Baolu Zhang, Yuchang Yao, Zhixian Wang, Jinlong Zhang, Xiaosheng Zhang, Guoshi Liu, Ning Li, Yixun Liu, and Zhengxing Lian, “Toll-Like Receptor 4 Promotes NO Synthesis by Upregulating GCHI Expression under Oxidative Stress Conditions in Sheep Monocytes/Macrophages,” Oxidative Medicine and Cellular Longevity, vol. 2015, pp. 1–11, 2015.
- Marlene Remely, and Alexander G. Haslberger, “The microbial epigenome in metabolic syndrome,” Molecular Aspects of Medicine, 2016.
- Yilin Liu, Dietbert Neumann, Jan F.C. Glatz, and Joost J.F.P. Luiken, “Molecular mechanism of lipid-induced cardiac insulin resistance and contractile dysfunction,” Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2016.
- Szu-Chi Hung, Wei-Ting Tseng, and Tzu-Ming Pan, “Lactobacillus paracasei subsp. paracasei NTU 101 ameliorates impaired glucose tolerance induced by a high-fat, high-fructose diet in Sprague-Dawley rats,” Journal of Functional Foods, vol. 24, pp. 472–481, 2016.
- Kalaivani Batumalaie, Muhammad Arif Amin, Dharmani Devi Murugan, Munavvar Zubaid Abdul Sattar, and Nor Azizan Abdullah, “Withaferin A protects against palmitic acid-induced endothelial insulin resistance and dysfunction through suppression of oxidative stress and inflammation,” Scientific Reports, vol. 6, pp. 27236, 2016.
- Agnieszka Zwolak, Olga Slabczynska, Justyna Semeniuk, Jadwiga Daniluk, and Agnieszka Szuster-Ciesielska, “Metformin Changes the Relationship between Blood Monocyte Toll-Like Receptor 4 Levels and Nonalcoholic Fatty Liver Disease-Ex Vivo Studies,” Plos One, vol. 11, no. 3, 2016.
- Anna-Maria Ordelheide, Nadja Gommer, Anja Böhm, Carina Hermann, Inga Thielker, Fausto Machicao, Andreas Fritsche, Norbert Stefan, Hans-Ulrich Häring, and Harald Staiger, “Granulocyte colony-stimulating factor (G-CSF): A saturated fatty acid-induced myokine with insulin-desensitizing properties in humans,” Molecular Metabolism, 2016.