Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2010, Article ID 367694, 10 pages
http://dx.doi.org/10.1155/2010/367694
Review Article

NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis

Department of Gastroenterology, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan

Received 1 May 2010; Accepted 22 October 2010

Academic Editor: Timothy R. Billiar

Copyright © 2010 Shin Maeda. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [42 citations]

The following is the list of published articles that have cited the current article.

  • Yong Zhou, Wen-Feng Huang, Qian Feng, Shi-Dai Shi, En-Liang Li, Ke-Hao Li, Rong-Shou Wu, and Lin-Quan Wu, “Toll-like receptor 4 regulates hepatitis B virus related hepatic carcinoma cell proliferation by controlling cyclin-dependent kinase 4/6 expression,” World Chinese Journal of Digestology, vol. 23, no. 19, pp. 3029–3037, 2005. View at Publisher · View at Google Scholar
  • Zehui Yan, Wenting Tan, Baoyan Xu, Yunjie Dan, Wenli Zhao, Chunqing Deng, Wen Chen, Shun Tan, Qing Mao, Yuming Wang, and Guohong Deng, “A cis-acting regulatory variation of the estrogen receptor α (ESR1) gene is associated with hepatitis B virus-related liver cirrhosis,” Human Mutation, vol. 32, no. 10, pp. 1128–1136, 2011. View at Publisher · View at Google Scholar
  • Hayato Nakagawa, Yoshihiro Hirata, Kohsuke Takeda, Yoku Hayakawa, Takehiro Sato, Hiroto Kinoshita, Kei Sakamoto, Wachiko Nakata, Yohko Hikiba, Masao Omata, Haruhiko Yoshida, Kazuhiko Koike, Hidenori Ichijo, and Shin Maeda, “Apoptosis Signal-Regulating Kinase 1 Inhibits Hepatocarcinogenesis by Controlling the Tumor-Suppressing Function of Stress-Activated Mitogen-Activated Protein Kinase,” Hepatology, vol. 54, no. 1, pp. 185–195, 2011. View at Publisher · View at Google Scholar
  • Ekihiro Seki, EekJoong Park, and Jiro Fujimoto, “Toll-like receptor signaling in liver regeneration, fibrosis and carcinogenesis,” Hepatology Research, vol. 41, no. 7, pp. 597–610, 2011. View at Publisher · View at Google Scholar
  • Ruth Broering, Mengji Lu, and Joerg F. Schlaak, “Role of Toll-like receptors in liver health and disease,” Clinical Science, vol. 121, no. 9-10, pp. 415–426, 2011. View at Publisher · View at Google Scholar
  • Samuel W French, James Lee, Jim Zhong, Timothy R Morgan, Virgil Buslon, William Lungo, and Barbara A French, “Alcoholic liver disease - Hepatocellular carcinoma transformation.,” Journal of gastrointestinal oncology, vol. 3, no. 3, pp. 174–81, 2012. View at Publisher · View at Google Scholar
  • Hayato Nakagawa, and Shin Maeda, “Inflammation- and stress-related signaling pathways in hepatocarcinogenesis,” World Journal of Gastroenterology, vol. 18, no. 31, pp. 4071–4081, 2012. View at Publisher · View at Google Scholar
  • Zehui Yan, Wenting Tan, Yunjie Dan, Wenli Zhao, Chunqing Deng, Yuming Wang, and Guohong Deng, “Estrogen receptor alpha gene polymorphisms and risk of HBV-related acute liver failure in the Chinese population,” Bmc Medical Genetics, vol. 13, 2012. View at Publisher · View at Google Scholar
  • Anton G. Kutikhin, and Arseniy E. Yuzhalin, “Inherited variation in pattern recognition receptors and cancer: Dangerous liaisons?,” Cancer Management and Research, vol. 4, no. 1, pp. 31–38, 2012. View at Publisher · View at Google Scholar
  • Dawn M. Torres, and Stephen A. Harrison, “Nonalcoholic Steatohepatitis and Noncirrhotic Hepatocellular Carcinoma: Fertile Soil,” Seminars In Liver Disease, vol. 32, no. 1, pp. 30–38, 2012. View at Publisher · View at Google Scholar
  • Yohei Shirakami, Seung-Ah Lee, Robin D. Clugston, and William S. Blaner, “Hepatic metabolism of retinoids and disease associations,” Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, vol. 1821, no. 1, pp. 124–136, 2012. View at Publisher · View at Google Scholar
  • Hayato Nakagawa, and Shin Maeda, “Molecular Mechanisms of Liver Injury and Hepatocarcinogenesis: Focusing on the Role of Stress-Activated MAPK,” Pathology Research International, vol. 2012, pp. 1–14, 2012. View at Publisher · View at Google Scholar
  • Noemí Eiró, Antonio Altadill, Luis M. Juárez, Manuel Rodríguez, Luis O. González, Sara Atienza, Sandra Bermúdez, Belen Fernandez-Garcia, Manuel F. Fresno-Forcelledo, Luis Rodrigo, and Francisco J. Vizoso, “Toll-like receptors 3, 4 and 9 in hepatocellular carcinoma: Relationship with clinicopathological characteristics and prognosis,” Hepatology Research, vol. 44, no. 7, pp. 769–778, 2013. View at Publisher · View at Google Scholar
  • Jun Yu, Jiayun Shen, Ting Ting Sun, Xiang Zhang, and Nathalie Wong, “Obesity, Insulin Resistance, NASH and Hepatocellular Carcinoma,” Seminars in Cancer Biology, 2013. View at Publisher · View at Google Scholar
  • H.-P. Li, X.-C. Zeng, B. Zhang, J.-T. Long, B. Zhou, G.-S. Tan, W.-X. Zeng, W. Chen, and J.-Y. Yang, “miR-451 inhibits cell proliferation in human hepatocellular carcinoma through direct suppression of IKK- ,” Carcinogenesis, 2013. View at Publisher · View at Google Scholar
  • Gang Ding, He-Dai Liu, Qian Huang, Hong-Xiang Liang, Zhao-Han Ding, Zhi-Jun Liao, and Gang Huang, “HDAC6 promotes hepatocellular carcinoma progression by inhibiting P53 transcriptional activity,” FEBS Letters, vol. 587, no. 7, pp. 880–886, 2013. View at Publisher · View at Google Scholar
  • Hiromi Hikita, Hayato Nakagawa, Ryosuke Tateishi, Ryota Masuzaki, Kenichiro Enooku, Haruhiko Yoshida, Masao Omata, Yoko Soroida, Mamiko Sato, Hiroaki Gotoh, Atsushi Suzuki, Tomomi Iwai, Hiromitsu Yokota, Kazuhiko Koike, Yutaka Yatomi, and Hitoshi Ikeda, “Perihepatic lymph node enlargement is a negative predictor of liver cancer development in chronic hepatitis C patients,” Journal Of Gastroenterology, vol. 48, no. 3, pp. 366–373, 2013. View at Publisher · View at Google Scholar
  • Rajagopal N. Aravalli, “Role of innate immunity in the development of hepatocellular carcinoma,” World Journal of Gastroenterology, vol. 19, no. 43, pp. 7500–7514, 2013. View at Publisher · View at Google Scholar
  • Jun Zhao, and Matthew W. Lawless, “Stop feeding cancer: Pro-inflammatory role of visceral adiposity in liver cancer,” Cytokine, 2013. View at Publisher · View at Google Scholar
  • Tracy Yuk-Nar Wong, Leo Lap-Yan Wong, Ian Pak-Yan Lam, Heong-Fai Liu, Lam-Lung Yeung, Yick-Pang Ching, and Wai-Lung Lai, “IPA-3 Inhibits the Growth of Liver Cancer Cells By Suppressing PAK1 and NF-kappa B Activation,” Plos One, vol. 8, no. 7, 2013. View at Publisher · View at Google Scholar
  • Mohammad Zare-Bidaki, Kyoko Tsukiyama-Kohara, and Mohammad Kazemi Arababadi, “Toll-Like Receptor 4 and Hepatitis B Infection: Molecular Mechanisms and Pathogenesis,” Viral Immunology, vol. 27, no. 7, pp. 321–326, 2014. View at Publisher · View at Google Scholar
  • Hangyu Li, Yan Li, Dan Liu, and Jingang Liu, “LPS promotes epithelial–mesenchymal transition and activation of TLR4/JNK signaling,” Tumor Biology, 2014. View at Publisher · View at Google Scholar
  • Amit Goel, Mahesh Gupta, and Rakesh Aggarwal, “Gut microbiota and liver disease,” Journal of Gastroenterology and Hepatology, vol. 29, no. 6, pp. 1139–1148, 2014. View at Publisher · View at Google Scholar
  • Joseph A. Odin, “Toll-like receptors and liver disease,” Liver International, vol. 34, no. 2, pp. 184–196, 2014. View at Publisher · View at Google Scholar
  • Vahid Bagheri, Azam Askari, Mohammad Kazemi Arababadi, and Derek Kennedy, “Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?,” Human Immunology, 2014. View at Publisher · View at Google Scholar
  • Seham A. Gadelhak, Mohamed M. Abdelaziz, Ayman T. Abbas, Nabil A. Gadelhak, and Hoda Mohamed El-Emshaty, “Serum P53 Abs in HCC patients with viral hepatitis - Type C,” Hepato-Gastroenterology, vol. 61, no. 134, pp. 1688–1695, 2014. View at Publisher · View at Google Scholar
  • Marlon J. A. Jetten, Ainhoa Ruiz-Aracama, Maarten L. J. Coonen, Sandra M. Claessen, Marcel H. M. van Herwijnen, Arjen Lommen, Joost H. M. van Delft, Ad A. C. M. Peijnenburg, and Jos C. S. Kleinjans, “Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes,” Archives of Toxicology, 2015. View at Publisher · View at Google Scholar
  • Letitia Adela Maria Streba, Cristin Constantin Vere, Ion Rogoveanu, and Costin Teodor Streba, “Nonalcoholic fatty liver disease, metabolic risk factors, and hepatocellular carcinoma: An open question,” World Journal Of Gastroenterology, vol. 21, no. 14, pp. 4103–4110, 2015. View at Publisher · View at Google Scholar
  • Yanli Zhang, Yunhong Li, Yalan Li, Rui Li, Yajun Ma, Hao Wang, and Yin Wang, “Chloroquine inhibits MGC803 gastric cancer cell migration via the Toll-like receptor 9/nuclear factor kappa B signaling pathway,” Molecular Medicine Reports, vol. 11, no. 2, pp. 1366–1371, 2015. View at Publisher · View at Google Scholar
  • Xiaoyu Fan, Chunyan He, Wei Jing, Xuyu Zhou, Rui Chen, Lei Cao, Minhui Zhu, Rongjie Jia, Hao Wang, Yajun Guo, and Jian Zhao, “Intracellular Osteopontin Inhibits Toll-like Receptor Signaling and Impedes Liver Carcinogenesis,” Cancer Research, vol. 75, no. 1, pp. 86–97, 2015. View at Publisher · View at Google Scholar
  • Jing Yang, Min Li, and Qi Chang Zheng, “Emerging role of Toll-like receptor 4 in hepatocellular carcinoma.,” Journal of hepatocellular carcinoma, vol. 2, pp. 11–7, 2015. View at Publisher · View at Google Scholar
  • Yi Zhe, Yan Li, Dan Liu, Dong-Ming Su, Jin-Gang Liu, and Hang-Yu Li, “Extracellular HSP70-peptide complexes promote the proliferation of hepatocellular carcinoma cells via TLR2/4/JNK1/2MAPK pathway,” Tumor Biology, 2016. View at Publisher · View at Google Scholar
  • Zahra Sepehri, Zohre Kiani, Ali Akbar Nasiri, and Farhad Kohan, “Toll-like receptor 2 and type 2 diabetes,” Cellular & Molecular Biology Letters, vol. 21, no. 1, 2016. View at Publisher · View at Google Scholar
  • Lindsey Devisscher, Xavier Verhelst, Isabelle Colle, Hans Van Vlierberghe, and Anja Geerts, “The role of macrophages in obesity-driven chronic liver disease,” Journal Of Leukocyte Biology, vol. 99, no. 5, pp. 693–698, 2016. View at Publisher · View at Google Scholar
  • Dawn M. Torres, and Stephen A. Harrison, “Occurrence of noncirrhotic HCC in NAFLD,” Clinical Dilemmas in Non-Alcoholic Fatty Liver Disease, pp. 50–57, 2016. View at Publisher · View at Google Scholar
  • Jorge André Gomes Lopes, Marta Borges-Canha, and Pedro Pimentel-Nunes, “Innate immunity and hepatocarcinoma: Can toll-like receptors open the door to oncogenesis?,” World Journal of Hepatology, vol. 8, no. 3, pp. 162–182, 2016. View at Publisher · View at Google Scholar
  • Safak Kiziltas, “Toll-like receptors in pathophysiology of liver diseases,” World Journal of Hepatology, vol. 8, no. 32, pp. 1354–1369, 2016. View at Publisher · View at Google Scholar
  • Zahra Sepehri, Zohre Kiani, Farhad Kohan, Seyed Moayed Alavian, and Saeid Ghavami, “Toll like receptor 4 and hepatocellular carcinoma; A systematic review,” Life Sciences, 2017. View at Publisher · View at Google Scholar
  • Ali Ravari, Tayebeh Mirzaei, Derek Kennedy, and Mohammad Kazemi Arababadi, “Chronoinflammaging in Alzheimer; A systematic review on the roles of toll like receptor 2,” Life Sciences, 2017. View at Publisher · View at Google Scholar
  • Dipanwita Das, Isha Sengupta, Neelakshi Sarkar, Ananya Pal, Debraj Saha, Manikankana Bandopadhyay, Chandrima Das, Jimmy Narayan, Shivaram Prasad Singh, Sekhar Chakrabarti, and Runu Chakravarty, “Anti-hepatitis B virus (HBV) response of imiquimod based toll like receptor 7 ligand in hbv-positive human hepatocelluar carcinoma cell line,” BMC Infectious Diseases, vol. 17, no. 1, 2017. View at Publisher · View at Google Scholar
  • K. A. Aitbaev, I. T. Murkamilov, and V. V. Fomin, “Liver diseases: The pathogenetic role of the gut microbiome and the potential of treatment for its modulation,” Terapevticheskii arkhiv, vol. 89, no. 8, pp. 120, 2017. View at Publisher · View at Google Scholar
  • Bangly Soliman, Ahmed Salem, Mohamed Ghazy, Nourhan Abu-Shahba, and Mahmoud El Hefnawi, “Bioinformatics functional analysis of let-7a, miR-34a, and miR-199a/b reveals novel insights into immune system pathways and cancer hallmarks for hepatocellular carcinoma,” Tumor Biology, vol. 40, no. 5, pp. 101042831877367, 2018. View at Publisher · View at Google Scholar