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Gastroenterology Research and Practice
Volume 2010, Article ID 453563, 13 pages
http://dx.doi.org/10.1155/2010/453563
Review Article

Contribution of Gut Bacteria to Liver Pathobiology

1Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
2Department of Surgery, University of Heidelberg, 69120, Heidelberg, Germany
3Department of Nutrition and Dietetics, College of Human Ecology, East Carolina University, 110 Rivers Building, Greenville, NC 27858-4353, USA

Received 16 April 2010; Accepted 17 June 2010

Academic Editor: Ekihiro Seki

Copyright © 2010 Gakuhei Son et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [55 citations]

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  • Ekihiro Seki, EekJoong Park, and Jiro Fujimoto, “Toll-like receptor signaling in liver regeneration, fibrosis and carcinogenesis,” Hepatology Research, vol. 41, no. 7, pp. 597–610, 2011. View at Publisher · View at Google Scholar
  • Jane Y. Yang, Jessica R. Karr, Jeramie D. Watrous, and Pieter C. Dorrestein, “Integrating '-omics' and natural product discovery platforms to investigate metabolic exchange in microbiomes,” Current Opinion In Chemical Biology, vol. 15, no. 1, pp. 79–87, 2011. View at Publisher · View at Google Scholar
  • Yan Lin, Le-Xing Yu, He-Xin Yan, Wen Yang, Liang Tang, Hui-Lu Zhang, Qiong Liu, Shan-Shan Zou, Ya-Qin He, Chao Wang, Meng-Chao Wu, and Hong-Yang Wang, “Gut-Derived Lipopolysaccharide Promotes T-Cell-Mediated Hepatitis in Mice through Toll-Like Receptor 4,” Cancer Prevention Research, vol. 5, no. 9, pp. 1090–1102, 2012. View at Publisher · View at Google Scholar
  • Jon S. Thompson, Rebecca A. Weseman, Fedja A. Rochling, Wendy J. Grant, Jean F. Botha, Alan N. Langnas, and David F. Mercer, “Preresection Obesity Increases the Risk of Hepatobiliary Complications in Short Bowel Syndrome,” Nutrients, vol. 4, no. 12, pp. 1358–1366, 2012. View at Publisher · View at Google Scholar
  • Shu-Chun Chuang, Teresa Norat, Neil Murphy, Anja Olsen, Anne Tjonneland, Kim Overvad, Marie Christine Boutron-Ruault, Florence Perquier, Laureen Dartois, Rudolf Kaaks, Birgit Teucher, Manuela M. Bergmann, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Sara Grioni, Carlotta Sacerdote, Salvatore Panico, Domenico Palli, Rosario Tumino, Petra H. M. Peeters, Bas Bueno-de-Mesquita, Martine M. Ros, Magritt Brustad, Lene Angell Asli, Guri Skeie, J. Ramon Quiros, Carlos A. Gonzalez, Maria-Jose Sanchez, Carmen Navarro, Eva Ardanaz Aicua, Miren Dorronsoro, Isabel Drake, Emily Sonestedt, Ingegerd Johansson, Goeran Hallmans, Timothy Key, Francesca Crowe, Kay-Tee Khaw, Nicholas Wareham, Pietro Ferrari, Nadia Slimani, Isabelle Romieu, Valentina Gallo, Elio Riboli, and Paolo Vineis, “Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort,” American Journal Of Clinical Nutrition, vol. 96, no. 1, pp. 164–174, 2012. View at Publisher · View at Google Scholar
  • D. Compare, P. Coccoli, A. Rocco, O.M. Nardone, S. De Maria, M. Cartenì, and G. Nardone, “Gut–liver axis: The impact of gut microbiota on non alcoholic fatty liver disease,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 22, no. 6, pp. 471–476, 2012. View at Publisher · View at Google Scholar
  • Youcai Zhang, Pallavi B. Limaye, Lois D. Lehman-McKeeman, and Curtis D. Klaassen, “Dysfunction of Organic Anion Transporting Polypeptide 1a1 Alters Intestinal Bacteria and Bile Acid Metabolism in Mice,” Plos One, vol. 7, no. 4, 2012. View at Publisher · View at Google Scholar
  • Arkadiusz R. Raczynski, Sureshkumar Muthupalani, Katherine Schlieper, James G. Fox, Steven R. Tannenbaum, and David B. Schauer, “Enteric Infection with Citrobacter rodentium Induces Coagulative Liver Necrosis and Hepatic Inflammation Prior to Peak Infection and Colonic Disease,” Plos One, vol. 7, no. 3, 2012. View at Publisher · View at Google Scholar
  • Ekihiro Seki, and Bernd Schnabl, “Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut,” Journal Of Physiology-London, vol. 590, no. 3, pp. 447–458, 2012. View at Publisher · View at Google Scholar
  • Elizabeth Brandon-Warner, Laura W. Schrum, C. Max Schmidt, and Iain H. McKillop, “Rodent models of alcoholic liver disease: Of mice and men,” Alcohol, vol. 46, no. 8, pp. 715–725, 2012. View at Publisher · View at Google Scholar
  • Matteo Garcovich, Maria Assunta Zocco, Davide Roccarina, Francesca Romana Ponziani, and Antonio Gasbarrini, “Prevention and treatment of hepatic encephalopathy: Focusing on gut microbiota,” World Journal Of Gastroenterology, vol. 18, no. 46, pp. 6693–6700, 2012. View at Publisher · View at Google Scholar
  • Joshua Gong, and Chengbo Yang, “Advances in the methods for studying gut microbiota and their relevance to the research of dietary fiber functions,” Food Research International, vol. 48, no. 2, pp. 916–929, 2012. View at Publisher · View at Google Scholar
  • Yeon Seok Seo, and Vijay H. Shah, “The role of gut-liver axis in the pathogenesis of liver cirrhosis and portal hypertension,” Clinical and Molecular Hepatology, vol. 18, no. 4, pp. 337, 2012. View at Publisher · View at Google Scholar
  • Manan Bawa, and Vivek A. Saraswat, “Gut–Liver Axis: Role of Inflammasomes,” Journal of Clinical and Experimental Hepatology, vol. 3, no. 2, pp. 141–149, 2013. View at Publisher · View at Google Scholar
  • Huawei Zeng, Jun Liu, Matthew I. Jackson, Feng-Qi Zhao, Lin Yan, and Gerald F. Combs, “Fatty Liver Accompanies an Increase in Lactobacillus Species in the Hind Gut of C57BL/6 Mice Fed a High-Fat Diet,” Journal Of Nutrition, vol. 143, no. 5, pp. 627–631, 2013. View at Publisher · View at Google Scholar
  • Haifeng Lu, Jianqing He, Zhongwen Wu, Wei Xu, Hua Zhang, Ping Ye, Jiezuan Yang, Shusen Zhen, and Lanjuan Li, “Assessment of Microbiome Variation During the Perioperative Period in Liver Transplant Patients: a Retrospective Analysis,” Microbial Ecology, vol. 65, no. 3, pp. 781–791, 2013. View at Publisher · View at Google Scholar
  • Deborah Cohen, and Diana Gonzales-Pacheco, “Pediatric nonalcoholic fatty liver disease: Review of etiologies, treatment, and implications for the dietetics practitioner,” Topics in Clinical Nutrition, vol. 28, no. 4, pp. 335–355, 2013. View at Publisher · View at Google Scholar
  • Craig N. Jenne, “Immune surveillance by the liver,” Nature Immunology, vol. 14, no. 10, pp. 996–1006, 2013. View at Publisher · View at Google Scholar
  • Debbie L. Shawcross, Thomas H. Tranah, and Iona Coltart, “Inflammation and hepatic encephalopathy,” Archives Of Biochemistry And Biophysics, vol. 536, no. 2, pp. 189–196, 2013. View at Publisher · View at Google Scholar
  • B. Lakshminarayanan, C. Stanton, P. W. O’Toole, and R. Paul Ross, “Compositional dynamics of the human intestinal microbiota with aging: Implications for health,” The journal of nutrition, health & aging, 2014. View at Publisher · View at Google Scholar
  • Thomas Tu, Magdalena A. Budzinska, Annette E. Maczurek, Robert Cheng, Anna Di Bartolomeo, Fiona J. Warner, Geoffrey W. McCaughan, Susan V. McLennan, and Nicholas A. Shackel, “Novel Aspects of the Liver Microenvironment in Hepatocellular Carcinoma Pathogenesis and Development,” International Journal of Molecular Sciences, vol. 15, no. 6, pp. 9422–9458, 2014. View at Publisher · View at Google Scholar
  • Eveliina Munukka, Satu Pekkala, Petri Wiklund, Omid Rasool, Ronald Borra, Lingjia Kong, Xiaowei Ojanen, Shu Mei Cheng, Christophe Roos, Soile Tuomela, Markku Alen, Riitta Lahesmaa, and Sulin Cheng, “Gut-adipose tissue axis in hepatic fat accumulation in humans,” Journal of Hepatology, 2014. View at Publisher · View at Google Scholar
  • Andrea Moro Caricilli, Angela Castoldi, and Niels Olsen Saraiva Câmara, “Intestinal barrier: A gentlemen's agreement between microbiota and immunity.,” World journal of gastrointestinal pathophysiology, vol. 5, no. 1, pp. 18–32, 2014. View at Publisher · View at Google Scholar
  • Sari Tuomisto, Tanja Pessi, Pekka Collin, Risto Vuento, Janne Aittoniemi, and Pekka J. Karhunen, “Changes in gut bacterial populations and their translocation into liver and ascites in alcoholic liver cirrhotics,” Bmc Gastroenterology, vol. 14, 2014. View at Publisher · View at Google Scholar
  • B. Lakshminarayanan, C. Stanton, P. W. O'Toole, and R. P. Ross, “Compositional dynamics of the human intestinal microbiota with aging: Implications for health,” Journal Of Nutrition Health & Aging, vol. 18, no. 9, pp. 773–786, 2014. View at Publisher · View at Google Scholar
  • Hong-Di Ma, Yin-Hu Wang, Christopher Chang, M. Eric Gershwin, and Zhe-Xiong Lian, “The Intestinal Microbiota and Microenvironment in Liver,” Autoimmunity Reviews, 2014. View at Publisher · View at Google Scholar
  • Julian R Marchesi, David H Adams, Francesca Fava, Gerben D A Hermes, Gideon M Hirschfield, Georgina Hold, Mohammed Nabil Quraishi, James Kinross, Hauke Smidt, Kieran M Tuohy, Linda V Thomas, Erwin G Zoetendal, and Ailsa Hart, “The gut microbiota and host health: a new clinical frontier,” Gut, vol. 65, no. 2, pp. 330–339, 2015. View at Publisher · View at Google Scholar
  • Ang Lin, Guan Wang, Huajun Zhao, Yuyi Zhang, Qiuju Han, Cai Zhang, Zhigang Tian, and Jian Zhang, “ TLR4 signaling promotes a COX-2/PGE 2 /STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells ,” OncoImmunology, vol. 5, no. 2, pp. e1074376, 2015. View at Publisher · View at Google Scholar
  • Haisong Wang, Xue Tang, Maureen Jepkorir Cheserek, Yonghui Shi, and Guowei Le, “Obesity prevention of synthetic polysaccharides in high-fat diet fed C57BL/6 mice,” Journal of Functional Foods, vol. 17, pp. 563–574, 2015. View at Publisher · View at Google Scholar
  • Jong Hyun Kim, Yu Jin Jang, Su Yeon An, Jeongsang Son, Jaehun Lee, Gyunggyu Lee, Ji Young Park, Han-Jin Park, Dong-Youn Hwang, Jong-Hoon Kim, and Jiyou Han, “Enhanced Metabolizing Activity of Human ES Cell-Derived Hepatocytes Using a 3D Culture System with Repeated Exposures to Xenobiotics,” Toxicological Sciences, vol. 147, no. 1, pp. 190–206, 2015. View at Publisher · View at Google Scholar
  • P.M. van Zyl, and G. Joubert, “Acetaldehyde production capacity of salivary microflora in alcoholics during early recovery,” Alcohol, 2015. View at Publisher · View at Google Scholar
  • Weiwei Jiang, Na Wu, Xuemei Wang, Yujing Chi, Yuanyuan Zhang, Xinyun Qiu, Ying Hu, Jing Li, and Yulan Liu, “Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease,” Scientific Reports, vol. 5, pp. 8096, 2015. View at Publisher · View at Google Scholar
  • X Zhou, Z Liu, X Cheng, Y Zheng, F Zeng, and Y He, “Socs1 and Socs3 degrades Traf6 via polyubiquitination in LPS-induced acute necrotizing pancreatitis,” Cell Death and Disease, vol. 6, no. 12, pp. e2012, 2015. View at Publisher · View at Google Scholar
  • Hui Peng, Eddie Wisse, and Zhigang Tian, “Liver natural killer cells: subsets and roles in liver immunity,” Cellular and Molecular Immunology, 2015. View at Publisher · View at Google Scholar
  • Weiyun Li, Jun Xiao, Xin Zhou, Ming Xu, Chaobo Hu, Xiaoyan Xu, Yao Lu, Chang Liu, Shengjie Xue, Lei Nie, Haibin Zhang, Zhiqi Li, Yanbo Zhang, Fu Ji, Lijian Hui, Wufan Tao, Bin Wei, and Hongyan Wang, “STK4 regulates TLR pathways and protects against chronic inflammation–related hepatocellular carcinoma,” Journal of Clinical Investigation, 2015. View at Publisher · View at Google Scholar
  • AbdelRahman Mahmoud Aly, AbdelReheem Adel, Ahmed Osama El-Gendy, Tamer M. Essam, and Ramy K. Aziz, “Gut microbiome alterations in patients with stage 4 hepatitis C,” Gut Pathogens, vol. 8, no. 1, 2016. View at Publisher · View at Google Scholar
  • Jella-Andrea Abraham, and Olga Golubnitschaja, “Time for paradigm change in management of hepatocellular carcinoma: is a personalized approach on the horizon?,” Personalized Medicine, 2016. View at Publisher · View at Google Scholar
  • Li Zeng, Benhua Zeng, Haiyang Wang, Bo Li, Ran Huo, Peng Zheng, Xiaotong Zhang, Xiangyu Du, Meiling Liu, Zheng Fang, Xuejiao Xu, Chanjuan Zhou, Jianjun Chen, Wenxia Li, Jing Guo, Hong Wei, and Peng Xie, “Microbiota Modulates Behavior and Protein Kinase C mediated cAMP response element-binding protein Signaling,” Scientific Reports, vol. 6, no. 1, 2016. View at Publisher · View at Google Scholar
  • James M. Henderson, Hui Emma Zhang, Natasa Polak, and Mark D. Gorrell, “Hepatocellular carcinoma: Mouse models and the potential roles of proteases,” Cancer Letters, 2016. View at Publisher · View at Google Scholar
  • Guoxiang Xie, Xiaoning Wang, Runmin Wei, Cynthia Rajani, Bing Dong, Defa Li, Wei Jia, Ping Liu, Wenlian Chen, Brenda Y. Hernandez, and Rosanna Alegado, “Distinctly altered gut microbiota in the progression of liver disease,” Oncotarget, vol. 7, no. 15, pp. 19355–19366, 2016. View at Publisher · View at Google Scholar
  • Ramesa Shafi Bhat, and Sooad Al-daihan, “Liver injury from ampicillin-induced intestinal microbiota distresses in rats fed carbohydrate- and protein-rich diets,” Tropical Journal Of Pharmaceutical Research, vol. 15, no. 4, pp. 709–716, 2016. View at Publisher · View at Google Scholar
  • Valeria García-Castillo, Enrique Sanhueza, Sergio A. Onate, Apolinaria García, and Eileen McNerney, “Pevjew microbiota dysbiosis: A new piece in the understanding of the carcinogenesis puzzle,” Journal of Medical Microbiology, vol. 65, no. 12, pp. 1347–1362, 2016. View at Publisher · View at Google Scholar
  • Albert J Czaja, “Factoring the intestinal microbiome into the pathogenesis of autoimmune hepatitis,” World Journal of Gastroenterology, vol. 22, no. 42, pp. 9257–9278, 2016. View at Publisher · View at Google Scholar
  • Byoungjin Park, Hye-Ree Lee, and Yong-Jae Lee, “Alcoholic liver disease: focus on prodromal gut health,” Journal of Digestive Diseases, vol. 17, no. 8, pp. 493–500, 2016. View at Publisher · View at Google Scholar
  • Terence N. Bukong, Banishree Saha, and Gyongyi Szabo, “HCV, Alcohol, and the Liver,” Hepatitis C Virus II, pp. 137–163, 2016. View at Publisher · View at Google Scholar
  • Pei Xiong Liew, and Paul Kubes, “Microanatomy and Immunity in the Liver,” Encyclopedia of Immunobiology, pp. 434–442, 2016. View at Publisher · View at Google Scholar
  • Khin May Oo, Aye Aye Lwin, Yi Yi Kyaw, Win Maw Tun, Kazutake Fukada, Akiko Goshima, Takashi Shimada, and Shigeru Okada, “Safety and long-term effect of the probiotic FK-23 in patients with hepatitis C virus infection,” Bioscience of Microbiota, Food and Health, vol. 35, no. 3, pp. 123–128, 2016. View at Publisher · View at Google Scholar
  • Zhan Zhang, Di Wang, Shanlei Qiao, Xinyue Wu, Shuyuan Cao, Li Wang, Xiaojian Su, and Lei Li, “Metabolic and microbial signatures in rat hepatocellular carcinoma treated with caffeic acid and chlorogenic acid,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Marco Sanduzzi Zamparelli, Alba Rocco, Debora Compare, and Gerardo Nardone, “The gut microbiota: A new potential driving force in liver cirrhosis and hepatocellular carcinoma,” United European Gastroenterology Journal, pp. 205064061770557, 2017. View at Publisher · View at Google Scholar
  • Xinyang Li, Jun Shen, and Zhihua Ran, “Crosstalk between the gut and the liver via susceptibility loci: Novel advances in inflammatory bowel disease and autoimmune liver disease,” Clinical Immunology, vol. 175, pp. 115–123, 2017. View at Publisher · View at Google Scholar
  • Yoon Seok Roh, Jong Won Kim, Surim Park, Changho Shon, Sokho Kim, Seong Kug Eo, Jung Kee Kwon, Chae Woong Lim, and Bumseok Kim, “Toll-Like Receptor-7 Signaling Promotes Nonalcoholic Steatohepatitis by Inhibiting Regulatory T Cells in Mice,” The American Journal of Pathology, 2018. View at Publisher · View at Google Scholar
  • Floriana Morgillo, Marcello Dallio, Carminia Maria Della Corte, Antonietta Gerarda Gravina, Giuseppe Viscardi, Carmelina Loguercio, Fortunato Ciardiello, and Alessandro Federico, “Carcinogenesis as a Result of Multiple Inflammatory and Oxidative Hits: a Comprehensive Review from Tumor Microenvironment to Gut Microbiota,” Neoplasia, vol. 20, no. 7, pp. 721–733, 2018. View at Publisher · View at Google Scholar
  • Paul Kubes, and Craig Jenne, “Immune Responses in the Liver,” Annual Review of Immunology, vol. 36, no. 1, 2018. View at Publisher · View at Google Scholar
  • Qingqing Wang, Bin Wang, Vijay Saxena, Lili Miles, Josh Tiao, Joel E. Mortensen, and Jaimie D. Nathan, “The gut-liver axis: impact of a mouse model of small-bowel bacterial overgrowth,” Journal of Surgical Research, vol. 221, pp. 246–256, 2018. View at Publisher · View at Google Scholar
  • Anna Alisi, Laura Stronati, Lorenzo Drago, Antonella Mosca, Federica Del Chierico, Pamela Vernocchi, Lorenza Putignani, Marco Toscano, Valerio Nobili, and Salvatore Cucchiara, “Bifidobacteria and lactobacilli in the gut microbiome of children with non-alcoholic fatty liver disease: which strains act as health players?,” Archives of Medical Science, vol. 14, no. 1, pp. 81–87, 2018. View at Publisher · View at Google Scholar