Research Article
IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population
Table 2
Genotype and allele counts for IL-12B and IL-23R variants in CD patients and in Caucasian controls.
| | | Control (%) | Case (%) | OR (95% CI) | |
| | IL-12B | C/C | 10 (2.9) | 11 (3.6) | 1.30 (0.54–3.12) | .638 | | rs1363670 | C/G | 71 (20.8) | 70 (23.3) | 1.17 (0.80–1.70) | | | G/G | 260 (76.3) | 220 (73.1) | 1.00 | | | HWE | 0.10 | 0.08 | | | | Cochran-Armitage Trend for G | , | 0.172 | | | | C | 91 (13.3) | 92 (15.3) | 1.17 (0.86–1.60) | .338 | | G | 591 (86.7) | 510 (84.7) | 1.00 | |
| | IL-12B | C/C | 39 (10.8) | 29 (9.2) | 0.79 (0.47–1.35) | .625 | | rs6887695 | C/G | 177 (48.9) | 148 (47.1) | 0.89 (0.65–1.23) | | | G/G | 146 (40.3) | 137 (43.6) | 1.00 | | | HWE | 0.21 | 0.25 | | | | C | 255 (35.2) | 206 (32.8) | 0.90 (0.72–1.13) | .358 | | G | 469 (64.8) | 422 (67.2) | 1.00 | |
| | IL-23R | A/A | 45 (12.5) | 37 (11.8) | 1.18 (0.72–1.93) | .030 | | rs10889677 | A/C | 146 (40.6) | 158 (50.5) | 1.55 (1.12–2.15) | | | C/C | 169 (46.9) | 118 (37.7) | 1.00 | | | HWE | 0.15 | 0.18 | | | | A | 236 (32.8) | 232 (37.1) | 1.21 (0.96–1.52) | .100 | | C | 484 (67.2) | 394 (62.9) | 1.00 | |
| | IL-23R | A/A | 5 (0.8) | 0 (0) | — | | | rs11209026 | A/G | 75 (11.9) | 28 (8.0) | 0.64 (0.41–1.01) | .164 | | G/G | 553 (87.4) | 321 (92.0) | 1.00 | | | HWE | 0.19 | 1.00 | | | | Cochran-Armitage Trend for G | , | 0.008 | | | | A | 85 (6.7) | 28 (4.0) | 0.58 (0.37–0.90) | .015 | | G | 1181 (93.3) | 670 (96.0) | 1.00 | |
| | IL-23R | C/C | 173 (47.3) | 123 (39.3) | 1.00 | .108 | | rs11805303 | C/T | 158 (43.2) | 153 (48.9) | 1.36 (0.99–1.88) | | | T/T | 35 (9.6) | 37 (11.8) | 1.49 (0.89–2.49) | | | HWE | 1.00 | 0.33 | | | | T | 228 (31.1) | 227 (36.3) | 1.26 (1.01–1.58) | .049 | | C | 504 (68.9) | 399 (63.7) | 1.00 | |
| | IL-23R | A/A | 56 (15.2) | 16 (5.1) | 0.29 (0.16–0.53) | .0002 | | rs1343151 | A/G | 154 (41.7) | 142 (45.4) | 0.95 (0.69–1.30) | | | G/G | 159 (43.1) | 155 (49.5) | 1.00 | | | HWE | 0.07 | 0.02 | | | | Cochran-Armitage Trend for G | , | 0.0006 | | | | A | 266 (36.0) | 174 (27.8) | 0.68 (0.54–0.86) | .001 | | G | 472 (64.0) | 452 (72.2) | 1.00 | |
| | IL-23R | G/G | 72 (19.6) | 29 (9.4) | 0.42 (0.25–0.70) | .001 | | rs7517847 | G/T | 183 (49.7) | 172 (55.7) | 0.98 (0.70–1.38) | | | T/T | 113 (30.7) | 108 (34.9) | 1.00 | | | HWE | 0.92 | 0.001 | | | | G | 327 (44.4) | 230 (37.2) | 0.74 (0.59–0.92) | .007 | | T | 409 (55.6) | 388 (62.8) | 1.00 | |
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