Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity

Figure 2

RIG-I discrimination of self and nonself RNA. The primary transcripts of cellular mRNA are produced in the nucleus and are modified before export to the cytoplasm; 5^'ppp is replaced by a 5^' cap structure on mRNAs while it is processed from tRNAs; microRNAs are processed to a length insufficient for RLR recognition. Cellular RNA-binding proteins can prevent RIG-I detection of 5^'-triphosphatae in rRNAs though masking as an RNP.