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Gastroenterology Research and Practice
Volume 2010 (2010), Article ID 860394, 4 pages
http://dx.doi.org/10.1155/2010/860394
Case Report

Successful Long-Term Use of Infliximab in Refractory Pouchitis in an Adolescent

Division of Gastroenterology and Nutrition, Department of Paediatrics, Faculty of Medicine, Dalhousie University, IWK Health Centre, 5850 University Avenue, Halifax, NS, Canada B3K 6R8

Received 1 August 2010; Accepted 18 December 2010

Academic Editor: Bo Shen

Copyright © 2010 Jessica Yeates and Mohsin Rashid. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pouchitis is a common complication that develops after an ileal pouch-anal anastomosis after colectomy for ulcerative colitis. In some cases, pouchitis becomes chronic and refractory to conventional therapies including antibiotics, corticosteroids, immunomodulators, probiotics, and anti-inflammatory drugs. We report a case of an adolescent with chronic pouchitis who not only improved with infliximab therapy but remains in long-term remission with maintenance therapy without any adverse effects. Infliximab is a safe and effective therapy for refractory pouchitis and may obviate the need for pouch removal and a permanent ileostomy.