Involvement of COX-2/PGE₂ Pathway in the Upregulation of MMP-9 Expression in Pancreatic Cancer

Figure 7

Migration analysis. Migration of BxPC-3 cells was increased after treatment with TNF-𝛼 (*𝑃<0.001, versus control), LPS (*𝑃<0.001, versus control), or PGE₂ (*𝑃<0.001, versus control). The increase caused by TNF-α or LPS was inhibited remarkably when NS398 was added (**𝑃<0.01, versus TNF; ***𝑃<0.01, versus LPS). Data are expressed as mean ± SD, 𝑛=3. NS: NS398.