Research Article
Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease
Table 2
Mean values of the cumulative percent oxidation of the 13C-MBT at 40 and 120 mins in various stages of chronic liver disease.
| Stages of liver disease | n | Cum. 40 minsa | Mean difference (95% CI) | P | Cum. 120 minsb | Mean difference (95% CI) | P |
| Fibrosis | 21 | 0.72 ± 0.17 | −0.07 | .33 | 0.85 ± 0.14 | −0.09 | .11 | Nonfibrosis/ inflammation | 9 | 0.80 ± 0.25 | (−0.24 to 0.08) | | 0.94 ± 0.19 | (−0.22 to 0.03) | | Cirrhosis | 47 | 0.25 ± 0.22 | −0.51 | <.0001 | 0.43 ± 0.26 | −0.47 | <.0001 | Noncirrhosis | 30 | 0.77 ± 0.19 | (−0.61 to −0.41) | | 0.89 ± 0.15 | (−0.57 to −0.36) | | CPA* cirrhosis | 12 | 0.45 ± 0.18 | −0.31 | <.0001 | 0.64 ± 0.19 | −0.25 | <.0001 | noncirrhosis | 29 | 0.76 ± 1.89 | (−0.44 to −0.18) | | 0.89 ± 0.15 | (−0.36 to −0.13) | | CPB# cirrhosis | 15 | 0.26 ± 0.17 | −0.41 | <.0001 | 0.46 ± 0.23 | −0.36 | <.0001 | CPA/noncirrhosis | 41 | 0.67 ± 0.23 | (−0.54 to −0.28) | | 0.82 ± 0.20 | (−0.49 to −0.24) | | CPC** cirrhosis | 21 | 0.12 ±0.19 | −0.44 | <.0001 | 0.28 ± 0.22 | −0.45 | <.0001 | Non-CPC cirrhosis | 56 | 0.56 ± 0.28 | (−0.57 to −0.30) | | 0.72 ± 0.26 | (−0.57 to −0.31) | |
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*Child-Pugh A, #Child-Pugh B, and **Child-Pugh C.
aNormal range: 0.90–1.20.
bNormal range: 0.80–1.10.
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