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Gastroenterology Research and Practice
Volume 2011, Article ID 601434, 13 pages
http://dx.doi.org/10.1155/2011/601434
Review Article

Cancer Cachexia: Mechanisms and Clinical Implications

1Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin, St James’ Hospital, Dublin 8, Ireland
2Department of Nutrition, Food Studies and Public Health, New York University, New York, NY 10003, USA

Received 31 May 2010; Accepted 7 April 2011

Academic Editor: Irit Chermesh

Copyright © 2011 Claire L. Donohoe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [105 citations]

The following is the list of published articles that have cited the current article.

  • Vanessa C. Vaughan, Melanie Sullivan-Gunn, Edward Hinch, Peter Martin, and Paul A. Lewandowski, “Eicosapentaenoic Acid and Oxypurinol in the Treatment of Muscle Wasting in a Mouse Model of Cancer Cachexia,” Plos One, vol. 7, no. 9, 2012. View at Publisher · View at Google Scholar
  • Tiziana Punzi, Ariele Fabris, Gabriele Morucci, Paolo Biagioni, Massimo Gulisano, Marco Ruggiero, and Stefania Pacini, “C-Reactive Protein Levels and Vitamin D Receptor Polymorphisms as Markers in Predicting Cachectic Syndrome in Cancer Patients,” Molecular Diagnosis & Therapy, vol. 16, no. 2, pp. 115–124, 2012. View at Publisher · View at Google Scholar
  • Marilia Seelaender, Miguel Batista, Fabio Lira, Renata Silverio, and Filippo Rossi-Fanelli, “Inflammation in cancer cachexia: To resolve or not to resolve (is that the question?),” Clinical Nutrition, vol. 31, no. 4, pp. 562–566, 2012. View at Publisher · View at Google Scholar
  • Ioannis Gioulbasanis, Athanasios Pallis, Panagiotis J. Vlachostergios, Alexandros Xyrafas, Zoe Giannousi, Isidora-Eleni Perdikouri, Michalitsa Makridou, Dionysia Kakalou, and Vassilios Georgoulias, “The Glasgow Prognostic Score (GPS) predicts toxicity and efficacy in platinum-based treated patients with metastatic lung cancer,” Lung Cancer, vol. 77, no. 2, pp. 383–388, 2012. View at Publisher · View at Google Scholar
  • D.D. Guest, E.M. Evans, and L.Q. Rogers, “Diet components associated with perceived fatigue in breast cancer survivors,” European Journal of Cancer Care, vol. 22, no. 1, pp. 51–59, 2012. View at Publisher · View at Google Scholar
  • Maurizio Muscaritoli, Fabio Penna, Paola Costelli, Alessio Molfino, Francesco M. Baccino, Gianfranco Gioia, and Filippo Rossi Fanelli, “New strategies for metabolic support in cancer,” Current Nutrition and Food Science, vol. 8, no. 2, pp. 139–148, 2012. View at Publisher · View at Google Scholar
  • Tiziana Punzi, Ariele Fabris, Gabriele Morucci, Paolo Biagioni, Massimo Gulisano, Marco Ruggiero, and Stefania Pacini, “C-reactive protein levels and vitamin d receptor polymorphisms as markers in predicting cachectic syndrome in cancer patients.,” Molecular diagnosis & therapy, vol. 16, no. 2, pp. 115–24, 2012. View at Publisher · View at Google Scholar
  • Sriram Yennurajalingam, Jie S. Willey, J. Lynn Palmer, Julio Allo, Egidio Del Fabbro, Evan N. Cohen, Sanda Tin, James M. Reuben, and Eduardo Bruera, “The Role of Thalidomide and Placebo for the Treatment of Cancer-Related Anorexia-Cachexia Symptoms: Results of a Double-Blind Placebo-Controlled Randomized Study,” Journal of Palliative Medicine, vol. 15, no. 10, pp. 1059–1064, 2012. View at Publisher · View at Google Scholar
  • Romina S. Goldszmid, and Giorgio Trinchieri, “The price of immunity,” Nature Immunology, vol. 13, no. 10, pp. 932–938, 2012. View at Publisher · View at Google Scholar
  • Vanessa C. Vaughan, Peter Martin, and Paul A. Lewandowski, “Cancer cachexia: impact, mechanisms and emerging treatments,” Journal of Cachexia, Sarcopenia and Muscle, 2012. View at Publisher · View at Google Scholar
  • Srinivasan Dasarathy, “Consilience in sarcopenia of cirrhosis,” Journal Of Cachexia Sarcopenia And Muscle, vol. 3, no. 4, pp. 225–237, 2012. View at Publisher · View at Google Scholar
  • Giorgio Trinchieri, “Cancer and Inflammation: An Old Intuition with Rapidly Evolving New Concept s,” Annual Review of Immunology, Vol 30, vol. 30, pp. 677–706, 2012. View at Publisher · View at Google Scholar
  • Tiziana Punzi, Ariele Fabris, Paolo Biagioni, Gabriele Morucci, Massimo Gulisano, Marco Ruggiero, and Stefania Pacini, “C-reactive protein levels and vitamin D receptor polymorphisms as markers in predicting cachectic syndrome in cancer patients,” Molecular Diagnosis and Therapy, vol. 16, no. 2, pp. 116–124, 2012. View at Publisher · View at Google Scholar
  • Konrad Matysiak, Michal Duszewski, and Tomasz Banasiewicz, “The role of dietary nutrition in stomach cancer,” Wspolczesna Onkologia-Contemporary Oncology, vol. 17, no. 4, pp. 343–345, 2013. View at Publisher · View at Google Scholar
  • James M Otto, Hugh E Montgomery, Alasdair F O'Doherty, Philip J Hennis, Jackie A Cooper, Michael Pw Grocott, Chris Snowdon, John B Carlisle, Michael Swart, and Toby Richards, “Association between preoperative haemoglobin concentration and cardiopulmonary exercise variables: a multicentre study.,” Perioperative medicine (London, England), vol. 2, no. 1, pp. 18, 2013. View at Publisher · View at Google Scholar
  • H. Suzuki, A. Asakawa, H. Amitani, N. Fujitsuka, N. Nakamura, and A. Inui, “Cancer Cachexia Pathophysiology and Translational Aspect of Herbal Medicine,” Japanese Journal of Clinical Oncology, 2013. View at Publisher · View at Google Scholar
  • Hajime Suzuki, Akihiro Asakawa, Haruka Amitani, Norifumi Nakamura, and Akio Inui, “Cancer cachexia-pathophysiology and management,” Journal of Gastroenterology, vol. 48, no. 5, pp. 574–594, 2013. View at Publisher · View at Google Scholar
  • Colleen S. Deane, David C. Hughes, Nicholas Sculthorpe, Mark P. Lewis, Claire E. Stewart, and Adam P. Sharples, “Impaired hypertrophy in myoblasts is improved with testosterone administration,” The Journal of Steroid Biochemistry and Molecular Biology, 2013. View at Publisher · View at Google Scholar
  • Ozkan Kanat, Erdem Cubukcu, Ferah Budak, Ilker Ercan, Mustafa Canhoroz, Fatih Olmez, and Nilufer Avci, “Comparison of three different treatment modalities in the management of cancer cachexia,” Tumori, vol. 99, no. 2, pp. 229–233, 2013. View at Publisher · View at Google Scholar
  • Gerald L. Klein, Bryon W. Petschow, Audrey L. Shaw, and Eric Weaver, “Gut barrier dysfunction and microbial translocation in cancer cachexia: a new therapeutic target,” Current Opinion in Supportive and Palliative Care, vol. 7, no. 4, pp. 361–367, 2013. View at Publisher · View at Google Scholar
  • Chowdhury Mobaswar Hossain, Bhabani Sankar Satapathy, Laboni Mondal, Samrat Chakraborty, and Biswajit Mukherjee, “Effect of streptozotocin-induced hyperglycemia on the progression of hepatocarcinogenesis in rats,” American Journal of Pharmacology and Toxicology, vol. 8, no. 4, pp. 170–178, 2013. View at Publisher · View at Google Scholar
  • Tomislav Letilovic, Sonja Perkov, Zlata Flegar Mestric, and Radovan Vrhovac, “Differences in routine laboratory parameters related to cachexia between patients with hematological diseases and patients with solid tumors or heart failure - is there only one cachexia?,” Nutrition Journal, vol. 12, 2013. View at Publisher · View at Google Scholar
  • V C Vaughan, M-R Hassing, and P A Lewandowski, “Marine polyunsaturated fatty acids and cancer therapy,” British Journal of Cancer, vol. 108, no. 3, pp. 486–492, 2013. View at Publisher · View at Google Scholar
  • Wilhelm Bloch, Eva Zopf, Philipp Zimmer, and Freerk T. Baumann, “Role of physical activity in tumor patients and possible underlying mechanisms,” European Review of Aging and Physical Activity, vol. 10, no. 1, pp. 25–32, 2013. View at Publisher · View at Google Scholar
  • Zbigniew Ben Zyliczpp. 191–201, 2013. View at Publisher · View at Google Scholar
  • Qj Yang Quanjun, Gj Yang Genjin, Ll Wan Lili, B Li Bin, J Lu Jin, Q Yu Qi, Y Li Yan, Yl Han Yonglong, C Guo Cheng, and Jp Zhang Junping, “Serum metabolic profiles reveal the effect of formoterol on cachexia in tumor-bearing mice,” Molecular Biosystems, vol. 9, no. 12, pp. 3015–3025, 2013. View at Publisher · View at Google Scholar
  • Claudio Pietra, Yasuhiro Takeda, Naoko Tazawa-Ogata, Masashi Minami, Xia Yuanfeng, Elizabeth Manning Duus, and Robert Northrup, “Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexia syndrome: preclinical profile,” Journal of Cachexia, Sarcopenia and Muscle, 2014. View at Publisher · View at Google Scholar
  • Guohao Wu, “Malnutrition and nutritional support in cancer patients,” Chinese Journal of Clinical Oncology, vol. 41, no. 18, pp. 1145–1149, 2014. View at Publisher · View at Google Scholar
  • Daniel Ackerman, and M. Celeste Simon, “Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment,” Trends in Cell Biology, 2014. View at Publisher · View at Google Scholar
  • Jan Budczies, Moritz von Winterfeld, Frederick Klauschen, Anna-Christin Kimmritz, Jan-Marcus Daniel, Arne Warth, Volker Endris, Carsten Denkert, Heidi Pfeiffer, Wilko Weichert, Manfred Dietel, Daniel Wittschieber, and Albrecht Stenzinger, “Comprehensive analysis of clinico-pathological data reveals heterogeneous relations between atherosclerosis and cancer,” Journal of Clinical Pathology, vol. 67, no. 6, pp. 482–490, 2014. View at Publisher · View at Google Scholar
  • Yingjian Jiang, Chuanyou Guo, Dianliang Zhang, Jian Zhang, Xiaojie Wang, and Changxin Geng, “The Altered Tight Junctions: An Important Gateway of Bacterial Translocation in Cachexia Patients with Advanced Gastric Cancer,” Journal of Interferon & Cytokine Research, pp. 140410121957001, 2014. View at Publisher · View at Google Scholar
  • S. A. Cichello, R. S. Weisinger, J. Schuijers, and M. Jois, “1-Sarcosine–angiotensin II infusion effects on food intake, weight loss, energy expenditure, and skeletal muscle UCP3 gene expression in a rat model,” Journal of Cachexia, Sarcopenia and Muscle, 2014. View at Publisher · View at Google Scholar
  • Ilaria Ronga, Fernando Gallucci, Ferdinando Riccardi, and Generoso Uomo, “Anorexia–cachexia syndrome in pancreatic cancer: Recent advances and new pharmacological approach,” Advances in Medical Sciences, 2014. View at Publisher · View at Google Scholar
  • Yingjian Jiang, Jizheng Lin, Dianliang Zhang, Zhouman Yu, Qiurong Li, Jun Jiang, and Jieshou Li, “Bacterial Translocation Contributes to Cachexia and Its Possible Pathway in Patients With Colon Cancer,” Journal of Clinical Gastroenterology, vol. 48, no. 2, pp. 131–137, 2014. View at Publisher · View at Google Scholar
  • Sarah M. Judge, Chia-Ling Wu, Adam W. Beharry, Brandon M. Roberts, Leonardo F. Ferreira, Susan C. Kandarian, and Andrew R. Judge, “Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia,” Bmc Cancer, vol. 14, 2014. View at Publisher · View at Google Scholar
  • Cui Chen, Peng Sun, Qiang-sheng Dai, Hui-wen Weng, He-ping Li, and Sheng Ye, “The Glasgow Prognostic Score Predicts Poor Survival in Cisplatin-Based Treated Patients with Metastatic Nasopharyngeal Carcinoma,” Plos One, vol. 9, no. 11, 2014. View at Publisher · View at Google Scholar
  • Marina Taus, Debora Busni, Daniele Fumelli, and Albano Nicolai, “Pathophysiology of malnutrition and cachexia in cancer patients,” Nutritional Therapy and Metabolism, vol. 32, no. 1, pp. 10–16, 2014. View at Publisher · View at Google Scholar
  • Rosamund C. Smith, Martin S. Cramer, Pamela J. Mitchell, Andrew Capen, Lysiane Huber, Rong Wang, Laura Myers, Bryan E. Jones, Brian J. Eastwood, Darryl Ballard, Jeff Hanson, Kelly M. Credille, Victor J. Wroblewski, Boris K. Lin, and Josef G. Heuer, “Myostatin Neutralization Results in Preservation of Muscle Mass and Strength in Preclinical Models of Tumor-Induced Muscle Wasting,” Molecular Cancer Therapeutics, vol. 14, no. 7, pp. 1661–1670, 2015. View at Publisher · View at Google Scholar
  • Vikas Dutt, Sanjeev Gupta, Rajesh Dabur, Elisha Injeti, and Ashwani Mittal, “Skeletal Muscle Atrophy: Potential Therapeutic Agents and Their Mechanisms of Action,” Pharmacological Research, 2015. View at Publisher · View at Google Scholar
  • Lisa P. Weethpp. 128–135, 2015. View at Publisher · View at Google Scholar
  • Hongjie Zhang, and Jose M Garcia, “Anamorelin hydrochloride for the treatment of cancer-anorexia-cachexia in NSCLC,” Expert Opinion on Pharmacotherapy, pp. 1–9, 2015. View at Publisher · View at Google Scholar
  • Tomoyoshi Aoyagi, Krista P Terracina, Ali Raza, Hisahiro Matsubara, and Kazuaki Takabe, “Cancer cachexia, mechanism and treatment.,” World journal of gastrointestinal oncology, vol. 7, no. 4, pp. 17–29, 2015. View at Publisher · View at Google Scholar
  • Michael Sanatani, Larry Stitt, Jawaid Younus, and Nazish Malik, “Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia,” Journal of Complementary and Integrative Medicine, vol. 12, no. 1, pp. 57–60, 2015. View at Publisher · View at Google Scholar
  • K. Kamachi, S. Ozawa, T. Hayashi, A. Kazuno, E. Ito, and H. Makuuchi, “Impact of body mass index on postoperative complications and long-term survival in patients with esophageal squamous cell cancer,” Diseases of the Esophagus, 2015. View at Publisher · View at Google Scholar
  • Poorna Anandavadivelan, and Pernilla Lagergren, “Cachexia in patients with oesophageal cancer,” Nature Reviews Clinical Oncology, 2015. View at Publisher · View at Google Scholar
  • Meng-Chuan Chen, Yen-Lin Chen, Chi-Feng Lee, Chih-Huang Hung, and Tz-Chong Chou, “Supplementation of Magnolol Attenuates Skeletal Muscle Atrophy in Bladder Cancer-Bearing Mice Undergoing Chemotherapy via Suppression of FoxO3 Activat,” Plos One, vol. 10, no. 11, 2015. View at Publisher · View at Google Scholar
  • Eran Israeli, and Charles N. Bernstein, “Gastrointentinal Manifestations of Systemic Diseases,” Yamada' s Textbook of Gastroenterology, pp. 2399–2439, 2015. View at Publisher · View at Google Scholar
  • Jiao Nie, Changlin Zhao, Li Deng, Jia Chen, Bin Yu, Xianlin Wu, Peng Pang, and Xiaoyin Chen, “Efficacy of traditional Chinese medicine in treating cancer,” Biomedical Reports, vol. 4, no. 1, pp. 3–14, 2015. View at Publisher · View at Google Scholar
  • Lorena Lerner, Julie Tao, Qing Liu, Richard Nicoletti, Bin Feng, Brian Krieger, Elizabeth Mazsa, Zakir Siddiquee, Ruoji Wang, Lucia Huang, Luhua Shen, Jie Lin, Antonio Vigano, M. Isabel Chiu, Zhigang Weng, William Winston, Solly Weiler, and Jeno Gyuris, “MAP3K11/GDF15 axis is a critical driver of cancer cachexia,” Journal of Cachexia, Sarcopenia and Muscle, 2015. View at Publisher · View at Google Scholar
  • John Tinsley, Jun Zou, Ting-Yu Wang, Tzong-Yueh Chen, Zeynab Heidari, Ralph Bickerdike, and Samuel A.M. Martin, “Regulatory factors controlling muscle mass: Competition between innate immune function and anabolic signals in regulation of atrogin-1 in Atlantic salmon,” Molecular Immunology, vol. 67, no. 2, pp. 341–349, 2015. View at Publisher · View at Google Scholar
  • Rubén Varela-Calviño, and Oscar J. Corderopp. 217–236, 2015. View at Publisher · View at Google Scholar
  • Yang Quan-Jun, Bian Jun, Wan Li-Li, Han Yong-Long, Li Bin, Yu Qi, Li Yan, Guo Cheng, and Yang Gen-Jin, “NMR-based metabolomics reveals distinct pathways mediated by curcumin in cachexia mice bearing CT26 tumor,” RSC Adv., vol. 5, no. 16, pp. 11766–11775, 2015. View at Publisher · View at Google Scholar
  • Xiaoya Xu, Man Jiang, Ying Zhang, Yuli Bi, and Mingyong Han, “Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor,” Molecular Medicine Reports, vol. 11, no. 1, pp. 289–294, 2015. View at Publisher · View at Google Scholar
  • Mashkova, and Ballyuzek, “Cachexia syndrome: The present state of the problem and importance in clinical practice,” Terapevticheskii Arkhiv, vol. 87, no. 8, pp. 111–118, 2015. View at Publisher · View at Google Scholar
  • Dexing Wang, Li Duan, Zhiquan Tu, Fei Yan, Cuicui Zhang, Xu Li, Yuzhu Cao, and Hongsheng Wen, “The Glasgow Prognostic Score Predicts Response to Chemotherapy in Patients with Metastatic Breast Cancer,” Chemotherapy, vol. 61, no. 4, pp. 217–222, 2015. View at Publisher · View at Google Scholar
  • Zhen Cao, and Shihua Zhang, “An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures,” Scientific Reports, vol. 6, pp. 33398, 2016. View at Publisher · View at Google Scholar
  • Meng-Chuan Chen, Wen-Lin Hsu, Pa-An Hwang, Yen-Lin Chen, and Tz-Chong Chou, “Combined administration of fucoidan ameliorates tumor and chemotherapy-induced skeletal muscle atrophy in bladder cancer-bearing mice,” Oncotarget, vol. 7, no. 32, pp. 51608–51618, 2016. View at Publisher · View at Google Scholar
  • Rosa Rosania, Costanza Chiapponi, Peter Malfertheiner, and Marino Venerito, “Nutrition in Patients with Gastric Cancer: An Update.,” Gastrointestinal tumors, vol. 2, no. 4, pp. 178–87, 2016. View at Publisher · View at Google Scholar
  • Shreesha Sukumaran, Hetal J. Patel, and Bhoomika M. Patel, “Evaluation of role of telmisartan in combination with 5-fluorouracil in gastric cancer cachexia,” Life Sciences, 2016. View at Publisher · View at Google Scholar
  • Aeyung Kim, Minju Im, and Jin Yeul Ma, “Sosiho-tang ameliorates cachexia-related symptoms in mice bearing colon 26 adenocarcinoma by reducing systemic inflammation and muscle loss,” Oncology Reports, vol. 35, no. 3, pp. 1841–1850, 2016. View at Publisher · View at Google Scholar
  • Guoxing Zhang, Xiujiang Li, Changping Sui, Hui Zhao, Jihong Zhao, Yue Hou, and Yujun Du, “Incidence and risk factor analysis for sarcopenia in patients with cancer,” Oncology Letters, vol. 11, no. 2, pp. 1230–1234, 2016. View at Publisher · View at Google Scholar
  • Tara C. Mueller, Jeannine Bachmann, Olga Prokopchuk, Helmut Friess, and Marc E. Martignoni, “Molecular pathways leading to loss of skeletal muscle mass in cancer cachexia – can findings from animal models be translated to humans?,” BMC Cancer, vol. 16, no. 1, 2016. View at Publisher · View at Google Scholar
  • David Scott, Joanne Reid, Peter Hudson, Peter Martin, and Sam Porter, “Health care professionals’ experience, understanding and perception of need of advanced cancer patients with cachexia and their families: The benefits of a dedicated clinic,” BMC Palliative Care, vol. 15, no. 1, 2016. View at Publisher · View at Google Scholar
  • Manpreet S. Mundi, Ryan T. Hurt, and Lisa Epp, “Increased Force Required with Proposed Standardized Enteral Feed Connector in Blenderized Tube Feeding,” Nutrition in Clinical Practice, vol. 31, no. 6, pp. 795–798, 2016. View at Publisher · View at Google Scholar
  • Ana T. Barata, Carla Santos, Marília Cravo, Maria do Céu Vinhas, Catarina Morais, Elisabete Carolino, Lino Mendes, Jorge Roldão Vieira, and Jorge Fonseca, “Handgrip Dynamometry and Patient-Generated Subjective Global Assessment in Patients with Nonresectable Lung Cancer,” Nutrition and Cancer, pp. 1–5, 2016. View at Publisher · View at Google Scholar
  • Hetal J. Patel, and Bhoomika M. Patel, “TNF-α and cancer cachexia: Molecular insights and clinical implications,” Life Sciences, 2016. View at Publisher · View at Google Scholar
  • Conor Murphy, and Carel le Roux, “The Neurobiological Impact of Ghrelin Suppression after Oesophagectomy,” International Journal of Molecular Sciences, vol. 18, no. 1, pp. 35, 2016. View at Publisher · View at Google Scholar
  • Qiu-Lei Xi, Ying Chen, Yu-Song Han, Qiu-Lin Zhuang, Hai-Yu Wang, Jing Fang, Guo-Hao Wu, Bo Zhang, Yi Jiang, Hai-Sheng Zhang, Qing-Yang Meng, and Jun Han, “Mitofusin-2 prevents skeletal muscle wasting in cancer cachexia,” Oncology Letters, vol. 12, no. 5, pp. 4013–4020, 2016. View at Publisher · View at Google Scholar
  • Neha S. Kwatra, Holly J. Meany, Sunil J. Ghelani, David Zahavi, Nayan Pandya, and Massoud Majd, “Glomerular hyperfiltration in children with cancer: prevalence and a hypothesis,” Pediatric Radiology, 2016. View at Publisher · View at Google Scholar
  • Emer M Guinan, Suzanne L Doyle, Linda O’Neill, Margaret R Dunne, Emma K Foley, Jacintha O’Sullivan, John V Reynolds, and Juliette Hussey, “Effects of a multimodal rehabilitation programme on inflammation and oxidative stress in oesophageal cancer survivors: the ReStOre feasibility study,” Supportive Care in Cancer, 2016. View at Publisher · View at Google Scholar
  • Anne Jirasek, Juliana Knief, Mario Deng, Katharina Reddemann, and Christoph Thorns, “Evaluation of general and coronary atherosclerosis and malignant disease demonstrates inverse correlations for specific cancer types as well as cancer in general,” Pathology - Research and Practice, 2016. View at Publisher · View at Google Scholar
  • Jutta Girke, Claudia Seipt, Andrea Markowski, Birgit Luettig, Anika Schettler, Michael Momma, and Andrea S. Schneider, “Quality of Life and Nutrition Condition of Patients Improve Under Home Parenteral Nutrition,” Nutrition in Clinical Practice, vol. 31, no. 5, pp. 659–665, 2016. View at Publisher · View at Google Scholar
  • Valiollah Mehrzad, Rohollah Afshar, and Mojtaba Akbari, “Pentoxifylline treatment in patients with cancer cachexia: A double-blind, randomized, placebo-controlled clinical trial.,” Advanced biomedical research, vol. 5, pp. 60, 2016. View at Publisher · View at Google Scholar
  • Zahra Nozhat, Masoomeh Hannani, and Mehdi Hedayati, “Can the serum level of myostatin be considered as an informative factor for cachexia prevention in patients with medullary thyroid cancer?,” Asian Pacific Journal of Cancer Prevention, vol. 17, pp. 119–123, 2016. View at Publisher · View at Google Scholar
  • Xianliang Zeng, Sizeng Chen, Yang Yang, and Zhao Ke, “Acylated and unacylated ghrelin inhibit atrophy in myotubes co-cultured with colon carcinoma cells.,” Oncotarget, vol. 8, no. 42, pp. 72872–72885, 2017. View at Publisher · View at Google Scholar
  • Ifeanyi D. Nwachukwu, Trevor M. Kouritzin, Rotimi E. Aluko, and Semone B. Myrie, “The role of omega-3 fatty acids in skeletal muscle anabolism, strength, and function in healthy and diseased states,” Journal of Food Biochemistry, pp. e12435, 2017. View at Publisher · View at Google Scholar
  • M. F. Ballyuzek, M. V. Mashkova, A. V. Arutjunyan, and V. A. Duke, “Melatonin as a marker of severity of cardiac disorders in developing cachexia syndrome among cancer patients of different age groups,” Advances in Gerontology, vol. 7, no. 3, pp. 228–235, 2017. View at Publisher · View at Google Scholar
  • Doyle, Fanning, Healy, Donohoe, Mc Hugh, Moore, Ravi, and John V. Reynolds, “Impact of supplemental home enteral feeding postesophagectomy on nutrition, body composition, quality of life, and patient satisfaction,” Diseases of the Esophagus, vol. 30, no. 9, pp. 1–9, 2017. View at Publisher · View at Google Scholar
  • Michelle Guan, Arvind M. Shinde, and Andrew E. Hendifar, “Pancreatic Cancer Cachexia: Current Concepts and Clinical Management,” Frailty and Sarcopenia - Onset, Development and Clinical Challenges, 2017. View at Publisher · View at Google Scholar
  • E. N. Ponnampalam, D. L. Hopkins, K. Giri, J. L. Jacobs, T. Plozza, P. Lewandowski, and A. Bekhit, “The use of oxidative stress biomarkers in live animals (in vivo) to predict meat quality deterioration postmortem (in vitro) caused by changes in muscle biochemical components1,” Journal of Animal Science, vol. 95, no. 7, pp. 3012–3024, 2017. View at Publisher · View at Google Scholar
  • Chia-Yen Hung, Tung-Liang Lin, Yung-Chia Kuo, Chia-Hsun Hsieh, Hung-Ming Wang, and Cheng-Lung Hsu, “Progesterone analogues reduce plasma Epstein–Barr virus DNA load and improve pain control in recurrent/metastatic nasopharyngeal carcinoma patients under supportive care,” Biomedical Journal, 2017. View at Publisher · View at Google Scholar
  • Skye Marshall, and Ekta Agarwal, “Comparing Characteristics of Malnutrition, Starvation, Sarcopenia and Cachexia in Older Adults,” Handbook of Famine, Starvation, and Nutrient Deprivation, pp. 1–23, 2017. View at Publisher · View at Google Scholar
  • Katherine A. Michaelis, Xinxia Zhu, Kevin G. Burfeind, Stephanie M. Krasnow, Peter R. Levasseur, Terry K. Morgan, and Daniel L. Marks, “Establishment and characterization of a novel murine model of pancreatic cancer cachexia,” Journal of Cachexia, Sarcopenia and Muscle, 2017. View at Publisher · View at Google Scholar
  • Elena Ongaro, Vanessa Buoro, Marika Cinausero, Riccardo Caccialanza, Annalisa Turri, Valentina Fanotto, Debora Basile, Maria Grazia Vitale, Paola Ermacora, Giovanni Gerardo Cardellino, Laura Nicoletti, Lorenzo Fornaro, Andrea Casadei-Gardini, and Giuseppe Aprile, “Sarcopenia in gastric cancer: when the loss costs too much,” Gastric Cancer, 2017. View at Publisher · View at Google Scholar
  • Clara Vazeille, Jean-Philippe Durand, Nathalie Neveux, Pascaline Boudou-Rouquette, François Goldwasser, Anne Jouinot, Olivier Huillard, Jérôme Alexandre, and Luc Cynober, “Relation between hypermetabolism, cachexia, and survival in cancer patients: A prospective study in 390 cancer patients before initiation of anticancer therapy,” American Journal of Clinical Nutrition, vol. 105, no. 5, pp. 1139–1147, 2017. View at Publisher · View at Google Scholar
  • Mohammad Aslam Khan, Shafquat Azim, Haseeb Zubair, Arun Bhardwaj, Girijesh Patel, Moh’d Khushman, Seema Singh, and Ajay Singh, “Molecular Drivers of Pancreatic Cancer Pathogenesis: Looking Inward to Move Forward,” International Journal of Molecular Sciences, vol. 18, no. 4, pp. 779, 2017. View at Publisher · View at Google Scholar
  • Jeremy L. Davis, and R. Taylor Ripley, “Postgastrectomy Syndromes and Nutritional Considerations Following Gastric Surgery,” Surgical Clinics of North America, vol. 97, no. 2, pp. 277–293, 2017. View at Publisher · View at Google Scholar
  • Kun-Siang Huang, Shih-Ho Wang, Seng-Kee Chuah, Kun-Ming Rau, Yu-Hung Lin, Meng-Che Hsieh, Li-Hsueh Shih, and Yen-Hao Chen, “The effects of hospice-shared care for gastric cancer patients,” Plos One, vol. 12, no. 2, pp. e0171365, 2017. View at Publisher · View at Google Scholar
  • Sine Roelsgaard Obling, Benedicte Vibjerg Wilson, Per Pfeiffer, and Jens Kjeldsen, “Home parenteral nutrition increases fat free mass in patients with incurable gastrointestinal cancer. Results of a randomized controlled trial,” Clinical Nutrition, 2017. View at Publisher · View at Google Scholar
  • Kenichi Nishie, Shuhei Yamamoto, Chie Nagata, Tomonobu Koizumi, and Masayuki Hanaoka, “Anamorelin for advanced non-small-cell lung cancer with cachexia: Systematic review and meta-analysis,” Lung Cancer, vol. 112, pp. 25–34, 2017. View at Publisher · View at Google Scholar
  • Ponnampalam, Jacobs, Plozza, Lewandowski, Hopkins, Giri, and Bekhit, “The use of oxidative stress biomarkers in live animals (In vivo) to predict meat quality deterioration postmortem (in vitro) caused by changes in muscle biochemical components,” Journal of Animal Science, vol. 95, no. 7, pp. 3012–3024, 2017. View at Publisher · View at Google Scholar
  • Daisuke Kawakita, Yukiko Sato, Chihiro Fushimi, Soichiro Takase, Hiroki Sato, Kuninori Otsuka, Koji Ebisumoto, Yuichiro Tada, Takafumi Togashi, Shingo Murakami, Toshitaka Nagao, Yorihisa Imanishi, Hiroyuki Ozawa, Kenji Okami, Akira Shimizu, Takuro Okada, Yoshihiro Watanabe, Akihiro Sakai, Yushi Ueki, Hisayuki Ota, Tomotaka Shimura, Toyoyuki Hanazawa, Shintaro Beppu, Kiyoaki Tsukahara, Satoshi Kano, and Yuichiro Sato, “Impact of hematological inflammatory markers on clinical outcome in patients with salivary duct carcinoma: A multiinstitutional study in Japan,” Oncotarget, vol. 8, no. 1, pp. 1083–1091, 2017. View at Publisher · View at Google Scholar
  • Steven J. Hughes, Shannon M. Wallet, Andrew R. Judge, Jose G. Trevino, Bayli B. DiVita, Michael H. Gerber, Daniel Delitto, Sarah M. Judge, Andrea E. Delitto, Rachel L. Nosacka, Fernanda G. Rocha, Thomas J. George, and Kevin E. Behrns, “Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia,” Oncotarget, vol. 8, no. 1, pp. 1177–1189, 2017. View at Publisher · View at Google Scholar
  • Eleonora Guadagnin, Davi Mázala, and Yi-Wen Chen, “STAT3 in Skeletal Muscle Function and Disorders,” International Journal of Molecular Sciences, vol. 19, no. 8, pp. 2265, 2018. View at Publisher · View at Google Scholar
  • Mohammadamin Sadeghi, Mahsa Keshavarz-Fathi, Vickie Baracos, Jann Arends, Maryam Mahmoudi, and Nima Rezaei, “Cancer cachexia: Diagnosis, assessment, and treatment,” Critical Reviews in Oncology/Hematology, vol. 127, pp. 91–104, 2018. View at Publisher · View at Google Scholar
  • Nichola Gale, David Wasley, Sioned Roberts, Karianne Backx, Annemarie Nelson, Robert van Deursen, and Anthony Byrne, “A longitudinal study of muscle strength and function in patients with cancer cachexia,” Supportive Care in Cancer, 2018. View at Publisher · View at Google Scholar
  • R. Taylor Ripley, Deborah R. Surman, Laurence P. Diggs, Jane B. Trepel, Min-Jung Lee, Jeremy Ryan, Jeremy L. Davis, Seth M. Steinberg, Jonathan M. Hernandez, Choung Hoang, Cara M. Kenney, Colleen D. Bond, Tricia F. Kunst, Anthony Letai, and David S. Schrump, “Metabolomic and BH3 profiling of esophageal cancers: novel assessment methods for precision therapy,” BMC Gastroenterology, vol. 18, no. 1, 2018. View at Publisher · View at Google Scholar
  • Michael Borean, Kishan Shani, M. Catherine Brown, Judy Chen, Mindy Liang, Joel Karkada, Simranjit Kooner, Mark K. Doherty, Grainne M. O'Kane, Raymond Jang, Elena Elimova, Rebecca K. Wong, Gail E. Darling, Wei Xu, Doris Howell, and Geoffrey Liu, “Development and evaluation of screening dysphagia tools for observational studies and routine care in cancer patients,” Health Science Reports, pp. e48, 2018. View at Publisher · View at Google Scholar
  • Qian Geng, Xiaolin Pu, Kun Yan, Qin Huang, and Ellen Hui Zhan, “Palliative Care,” Gastric Cardiac Cancer, pp. 299–315, 2018. View at Publisher · View at Google Scholar
  • Xianliang Zeng, Sizeng Chen, Yanfeng Lin, and Zhao Ke, “Acylated and unacylated ghrelin inhibit apoptosis in myoblasts cocultured with colon carcinoma cells,” Oncology Reports, vol. 39, no. 3, pp. 1387–1395, 2018. View at Publisher · View at Google Scholar
  • Ilaria Trestini, Luisa Carbognin, Clelia Bonaiuto, Giampaolo Tortora, and Emilio Bria, “The obesity paradox in cancer: clinical insights and perspectives,” Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, 2018. View at Publisher · View at Google Scholar
  • Louise E. Daly, Éadaoin B. Ní Bhuachalla, Derek G. Power, Samantha J. Cushen, Karl James, and Aoife M. Ryan, “Loss of skeletal muscle during systemic chemotherapy is prognostic of poor survival in patients with foregut cancer,” Journal of Cachexia, Sarcopenia and Muscle, 2018. View at Publisher · View at Google Scholar
  • Ozkan Kanat, Erdem Cubukcu, Nilufer Avci, Ferah Budak, Ilker Ercan, Mustafa Canhoroz, and Fatih Olmez, “Comparison of Three Different Treatment Modalities in the Management of Cancer Cachexia,” Tumori Journal, vol. 99, no. 2, pp. 229–233, 2018. View at Publisher · View at Google Scholar
  • Tyler Maher, and Miriam E. Clegg, “Dietary lipids with potential to affect satiety: Mechanisms and evidence,” Critical Reviews in Food Science and Nutrition, pp. 1–26, 2018. View at Publisher · View at Google Scholar
  • Aeyung Kim, Jin Yeul Ma, and Minju Im, “A novel herbal formula, SGE, induces endoplasmic reticulum stress-mediated cancer cell death and alleviates cachexia symptoms induced by colon-26 adenocarcinoma,” Oncotarget, vol. 9, no. 23, pp. 16284–16296, 2018. View at Publisher · View at Google Scholar