Efficacy of Diosmectite (Smecta)^® in the Treatment of Acute Watery Diarrhoea in Adults: A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study

Table 1

Demographics, previous medical history, and characteristics of the acute diarrhoea episode.

	Diosmectite	Placebo	𝑃 value
	𝑁=166	𝑁=163
Demographics
Male, 𝑛 (%)	89 (53.6)	86 (52.8)	.88^a
Age (years), median [range]	38.0 [19–63]	38.0 [19–66]	.84^b
Height, females (cm), median [range]	162.0 [150–180]	162.0 [150–182]	.74^b
Height, males (cm), median [range]	172.0 [158–202]	173.0 [158–189]	.33^b
Weight, females (kg), median [range]	64.0 [40–94]	66.0 [44–102]	.29^b
Weight, males (kg), median [range]	78.0 [49–107]	76.0 [55–152]	.24^b
Characteristics of the diarrhoea episode
Previous history of gastrointestinal disorders, 𝑛 (%)	9 (5.4)	13 (8.0)	.35^a
Days from the 1st watery stool to inclusion, median [range]	1.0 [0–3]	1.0 [0–3]	.90^b
Nausea, abdominal pain, or anal irritation, 𝑛 (%)	156 (94)	148 (90.8)	.28^a
Number of stools over the past 24 hours, median [range]	5.0 [2–22]	6.0 [3–20]	.17^b
Positive stool culture, 𝑛 (%)	40 (29.2)	33 (22.9)	.23^a
Rotavirus	16 (11.9)	14 (10.0)	.61^a
Adenovirus	7 (5.4)	3 (2.2)	.21^a
Escherichia coli	13 (9.6)	13 (9.3)	.92^a
Staphylococcus aureus	4 (2.9)	2 (1.4)	.44^a
Amoebiasis	4 (2.9)	1 (0.7)	.21^a

^a2-tailed Chi-square test; ^bWilcoxon’s test.