Identification of Regional Lymph Node Involvement of Colorectal Cancer by Serum SELDI Proteomic Patterns

Figure 2

The pattern-matching algorithm to distinguish node-positive CRC patients from node-negative CRC patients on learning mode of training set. The left branch node after Node 1 is the cases of the linear combination: −0.075 (m/z 3,104) −0.231 (m/z 3,781) + 0.157 (m/z 5,867) + 0.086 (m/z 7,970) + 0.953 (m/z 9,290) ≤1.122, and the right one is >1.122. The left branch node after the Node 2 is the linear combination: 0.410 (m/z 3,781) −0.912 (m/z 5,867) ≤0.248, and the right one is >0.248. The cases met to the conditions of Terminal Node 1 and Terminal Node 3 were diagnosed as node-positive CRC patients, and those met to the conditions of Terminal Node 2 were diagnosed as node-negative CRC patients. 𝑁 represents the number of samples. m/z represents the mass to charge ratio.