Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2011, Article ID 917941, 9 pages
http://dx.doi.org/10.1155/2011/917941
Review Article

Radiation Proctitis: Current Strategies in Management

Division of Colon and Rectal Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School Boston, 330 Brookline Avenue, Stoneman 9, Boston, MA 02215, USA

Received 31 January 2011; Revised 15 June 2011; Accepted 23 August 2011

Academic Editor: Jean S. Wang

Copyright © 2011 Nhue L. Do et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [37 citations]

The following is the list of published articles that have cited the current article.

  • Michael Karanikas, George Kouklakis, Panagiotis Touzopoulos, Alexandros Mitrakas, Petros Zezos, Paul Zarogoulidis, Nikolaos Machairiotis, Eleni Efremidou, Nikolaos Liratzopoulos, and Alexandros Polychronidis, “Benign post-radiation rectal stricture treated with endoscopic balloon dilation and intralesional triamcinolone injection,” Case Reports in Gastroenterology, vol. 6, no. 3, pp. 583–589, 2012. View at Publisher · View at Google Scholar
  • M. R. Chruscielewska-Kiliszek, J. Regula, M. Polkowski, M. Rupinski, E. Kraszewska, J. Pachlewski, E. Czaczkowska-Kurek, and E. Butruk, “Sucralfate or placebo following argon plasma coagulation for chronic radiation proctitis: a randomized double blind trial,” Colorectal Disease, vol. 15, no. 1, pp. e48–e55, 2012. View at Publisher · View at Google Scholar
  • Niamh M. Hogan, Michael J. Kerin, and Myles R. Joyce, “Gastrointestinal complications of pelvic radiotherapy: Medical and surgical management strategies,” Current Problems in Surgery, vol. 50, no. 9, pp. 395–407, 2013. View at Publisher · View at Google Scholar
  • Rhodri Stacey, and John T. Green, “Nonendoscopic therapies for the management of radiation-induced rectal bleeding,” Current Opinion in Supportive and Palliative Care, vol. 7, no. 2, pp. 175–182, 2013. View at Publisher · View at Google Scholar
  • Ankur Khosla, Oludayo Adeyefa, and Syed Nasir, “Successful Treatment of Radiation-Induced Proctitis Pain by Blockade of the Ganglion Impar in an Elderly Patient with Prostate Cancer: A Case Report,” Pain Medicine, vol. 14, no. 5, pp. 662–666, 2013. View at Publisher · View at Google Scholar
  • Assaad M. Soweid, and Mohammed H. Saadpp. 333–344, 2013. View at Publisher · View at Google Scholar
  • Daniele Pironi, Alessandra Panarese, Maurizio Vendettuoli, Stefano Pontone, Salvatore Candioli, Annarita Manigrasso, Flaminia De Cristofaro, and Angelo Filippini, “Chronic radiation-induced proctitis: the 4 % formalin application as non-surgical treatment,” International Journal Of Colorectal Disease, vol. 28, no. 2, pp. 261–266, 2013. View at Publisher · View at Google Scholar
  • Ankit Sarin, “Management of Radiation Proctitis,” Gastroenterology Clinics of North America, vol. 42, no. 4, pp. 913–+, 2013. View at Publisher · View at Google Scholar
  • G Ahlenstiel, R Sonson, and Mj Bourke, “Diagnosis and Treatment of Radiation Proctitis,” Video Journal and Encyclopedia of GI Endoscopy, vol. 1, no. 2, pp. 316–317, 2013. View at Publisher · View at Google Scholar
  • Jeremy G. Price, Richard G. Stock, and Nelson N. Stone, “Predictive Factors and Management of Rectal Bleeding Side Effects Following Prostate Cancer Brachytherapy,” International Journal Of Radiation Oncology Biology Physics, vol. 86, no. 5, pp. 842–847, 2013. View at Publisher · View at Google Scholar
  • Karamanolis, Delladetsima, Kouloulias, Papaxoinis, Panayiotides, Haldeopoulos, Triantafyllou, Kelekis, and Ladas, “Increased expression of VEGF and CD31 in postradiation rectal tissue: Implications for radiation proctitis,” Mediators of Inflammation, vol. 2013, 2013. View at Publisher · View at Google Scholar
  • Kestutis Petrulis, Alfredas Kilius, Darius Norkus, Audrius Dulskas, Konstantinas Povilas Valuckas, Narimantas Evaldas Samalavicius, and Arvydas Burneckis, “Treatment of hemorrhagic radiation-induced proctopathy with a 4% formalin application under perianal anesthetic infiltration,” World Journal Of Gastroenterology, vol. 19, no. 30, pp. 4944–4949, 2013. View at Publisher · View at Google Scholar
  • Ted A. Skolarus, Andrew M. D. Wolf, Nicole L. Erb, Durado D. Brooks, Brian M. Rivers, Willie Underwood, Andrew L. Salner, Michael J. Zelefsky, Jeanny B. Aragon-Ching, Susan F. Slovin, Daniela A. Wittmann, Michael A. Hoyt, Victoria J. Sinibaldi, Gerald Chodak, Mandi L. Pratt-Chapman, and Rebecca L. Cowens-Alvarado, “American Cancer Society Prostate Cancer Survivorship Care Guidelines,” Ca-A Cancer Journal for Clinicians, vol. 64, no. 4, pp. 226–249, 2014. View at Publisher · View at Google Scholar
  • Nawaid Usmani, Nelson Leong, Kevin Martell, Lanna Lan, Sunita Ghosh, Nadeem Pervez, John Pedersen, Don Yee, Albert Murtha, John Amanie, Ron Sloboda, David Murray, and Matthew Parliament, “Single-nucleotide polymorphisms studied for associations with urinary toxicity from 125I prostate brachytherapy implants,” Brachytherapy, vol. 13, no. 3, pp. 285–291, 2014. View at Publisher · View at Google Scholar
  • Mariana Nascimento, José Eduardo Aguilar-Nascimento, Cervantes Caporossi, Heloisa Michelon Castro-Barcellos, and Rodrigo Teixeira Motta, “Efficacy of Synbiotics to Reduce Acute Radiation Proctitis Symptoms and Improve Quality of Life: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial,” International Journal of Radiation Oncology*Biology*Physics, vol. 90, no. 2, pp. 289–295, 2014. View at Publisher · View at Google Scholar
  • Rhodri Stacey, and John T. Green, “Radiation-induced small bowel disease: Latest developments and clinical guidance,” Therapeutic Advances in Chronic Disease, vol. 5, no. 1, pp. 15–29, 2014. View at Publisher · View at Google Scholar
  • Marc B. Grodsky, and Shafik M. Sidani, “Radiation Proctopathy,” Clinics In Colon And Rectal Surgery, vol. 28, no. 2, pp. 103–111, 2015. View at Publisher · View at Google Scholar
  • Xian-rui Wu, Xiu-li Liu, Seymour Katz, and Bo Shen, “Pathogenesis, Diagnosis, and Management of Ulcerative Proctitis, Chronic Radiation Proctopathy, and Diversion Proctitis,” Inflammatory Bowel Diseases, vol. 21, no. 3, pp. 703–715, 2015. View at Publisher · View at Google Scholar
  • Kirsten Al Morris, and Najib Y Haboubi, “Pelvic radiation therapy: Between delight and disaster.,” World journal of gastrointestinal surgery, vol. 7, no. 11, pp. 279–88, 2015. View at Publisher · View at Google Scholar
  • Ben G. L. Vanneste, Lien Van De Voorde, Rogier J. de Ridder, Evert J. Van Limbergen, Philippe Lambin, and Emile N. van Lin, “Chronic radiation proctitis: tricks to prevent and treat,” International Journal Of Colorectal Disease, vol. 30, no. 10, pp. 1293–1303, 2015. View at Publisher · View at Google Scholar
  • Fleur T van de Wetering, Leen Verleye, H. Jervoise N Andreyev, Jane Maher, Joan Vlayen, Bradley R Pieters, Geertjan van Tienhoven, and Rob JPM ScholtenCochrane Database of Systematic Reviews, 2016. View at Publisher · View at Google Scholar
  • S. S. Nair, J. J. Manalil, S. K. Ramavarma, I. M. Suseela, A. Thekkepatt, and A. C. Raghavamenon, “Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice,” Human & Experimental Toxicology, vol. 35, no. 2, pp. 205–212, 2016. View at Publisher · View at Google Scholar
  • Piotr Zelga, Marcin Tchórzewski, Marta Zelga, Janusz Sobotkowski, and Adam Dziki, “Radiation-induced rectovaginal fistulas in locally advanced gynaecological malignancies—new patients, old problem?,” Langenbeck's Archives of Surgery, 2016. View at Publisher · View at Google Scholar
  • Kalyanakrishnan Ramakrishnanpp. 1181–1197, 2016. View at Publisher · View at Google Scholar
  • Luciano Lenz, Rachel Rohr, Frank Nakao, Ermelindo Libera, and Angelo Ferrari, “Chronic radiation proctopathy: A practical review of endoscopic treatment,” World Journal of Gastrointestinal Surgery, vol. 8, no. 2, pp. 151, 2016. View at Publisher · View at Google Scholar
  • Vishnu Prasad Nelamangala Ramakrishnaiah, and Srinivasan Krishnamachari, “Chronic haemorrhagic radiation proctitis: A review,” World Journal of Gastrointestinal Surgery, vol. 8, no. 7, pp. 483, 2016. View at Publisher · View at Google Scholar
  • F. Goupy, E. Chajon, J. Castelli, É. Le Prisé, L. Duvergé, N. Jaksic, G. Vogin, É. Monpetit, V. Klein, L. de Bosschère, and P. Maingon, “Contraintes de doses aux organes à risque en radiothérapie conformationnelle et stéréotaxique : intestin grêle et duodénum,” Cancer/Radiothérapie, 2017. View at Publisher · View at Google Scholar
  • Yu-Ming Wang, Chong-Jong Wang, Fu-Min Fang, Hui-Chun Chen, Hsuan-Chih Hsu, Yu-Jie Huang, Chang-Yu Wang, and Eng-Yen Huang, “Differences in the outcomes and complications between elderly and younger uterine cervical cancer patients treated by definitive radiotherapy — A propensity score-matched study,” Gynecologic Oncology, 2017. View at Publisher · View at Google Scholar
  • Qinghua Zhong, Zixu Yuan, Lili Chu, Jianping Wang, Lei Wang, Tenghui Ma, Huaiming Wang, and Qiyuan Qin, “Restorative resection of radiation rectovaginal fistula can better relieve anorectal symptoms than colostomy only,” World Journal of Surgical Oncology, vol. 15, no. 1, 2017. View at Publisher · View at Google Scholar
  • Akhtar Mahmood, Mumtaz Anwar, Shabeer Ahmad, Reyhan Akhtar, and Safrun Mahmood, “Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis,” Technology in Cancer Research and Treatment, vol. 16, no. 6, pp. 676–691, 2017. View at Publisher · View at Google Scholar
  • Nobuhisa Takase, Kimihiro Yamashita, Yasuo Sumi, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Yoshiko Matsuda, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yu-Ichiro Koma, Masato Komatsu, Ryohei Sasaki, and Yoshihiro Kakeji, “Local advanced rectal cancer perforation in the midst of preoperative chemoradiotherapy: A case report and literature review,” World Journal of Clinical Cases, vol. 5, no. 1, pp. 18, 2017. View at Publisher · View at Google Scholar
  • I. V. Sycheva, “Treatment Of Radiation-Induced Pelvic Damage After Radiation Therapy For Prostate Cancer,” Siberian journal of oncology, vol. 17, no. 3, pp. 64–71, 2018. View at Publisher · View at Google Scholar
  • Nanan Lv, Jiao Chen, Fengshuang Li, Ding Ding, Simeng Jiao, Yinuo Wang, Weimin Kong, Hui Zhao, and Dan Song, “Incidence of radiation enteritis in cervical cancer patients treated with definitive radiotherapy versus adjuvant radiotherapy,” Journal of Cancer Research and Therapeutics, vol. 14, no. 8, pp. S120–S124, 2018. View at Publisher · View at Google Scholar
  • Masoud Najafi, Elahe Motevaseli, Alireza Shirazi, Ghazale Geraily, Abolhasan Rezaeyan, Farzad Norouzi, Saeed Rezapoor, and Hamid Abdollahi, “Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications,” International Journal of Radiation Biology, pp. 1–22, 2018. View at Publisher · View at Google Scholar
  • Payel Bhanja, Pooja Gupta-Saraf, Andrew Hoover, Subhrajit Saha, and Andrew Norris, “BCN057 induces intestinal stem cell repair and mitigates radiation-induced intestinal injury,” Stem Cell Research and Therapy, vol. 9, no. 1, 2018. View at Publisher · View at Google Scholar
  • Fa Chyi Lee, Joshua A. Hanson, Ashwani Rajput, Glenory Heywood, Ben J. Liem, Pranshu Bansal, M. Houman Fekrazad, Emilio P. Araujo-Mino, Yehuda Z. Patt, and Cristina Murray-Krezan, “Phase II Trial Using a Combination of Oxaliplatin, Capecitabine, and Celecoxib with Concurrent Radiation for Newly Diagnosed Resectable Rectal Cancer,” Oncologist, vol. 23, no. 1, pp. 2–e5, 2018. View at Publisher · View at Google Scholar
  • Erkan Yavuz, Onur Olgac Karagulle, Gulcin Ercan, Atilla Celik, Hakan Yigitbas, Busra Yaprak Bayrak, Rumeysa Tartar, Ramazan Kusaslan, Yuksel Altinel, and Osman Bilgin Gulcicek, “Evaluation of prophylactic and therapeutic effects of ruscogenin on acute radiation proctitis: an experimental rat model,” Annals of Surgical Treatment and Research, vol. 94, no. 4, pp. 174, 2018. View at Publisher · View at Google Scholar