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Gastroenterology Research and Practice
Volume 2011 (2011), Article ID 924045, 15 pages
http://dx.doi.org/10.1155/2011/924045
Research Article

Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments

1Food Hygiene, Division of Applied Nutrition and Food Chemistry, Lund University, 221 00 Lund, Sweden
2Division of Applied Nutrition and Food Chemistry, Lund University, 221 00 Lund, Sweden
3Department of Surgery, Skåne University Hospital, Lund University, 205 02 Malmö, Sweden

Received 18 February 2011; Accepted 2 August 2011

Academic Editor: Genevieve B. Melton-Meaux

Copyright © 2011 Åsa Håkansson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model. Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edematous and the number of haemorrhagic erosions and quantity of dysplastic lesions were higher as well as the mucosal concentration of myeloperoxidase and faecal viable count of Enterobacteriaceae. The livers were affected as evaluated by steatosis, parenchymal loss, haemorrhage, and inflammatory infiltrations, and higher proportions of acetate and lower proportions of butyrate in colonic content were found. The DSS model seems to mimic the clinical situation and may be valuable for investigation of inflammation-related dysplasia and colon cancer, as well as for altered liver function by endogenous inflammatory mediators.