TY - JOUR A2 - Melton-Meaux, Genevieve B. AU - Yoon, Sonia S. AU - Sun, Jun PY - 2011 DA - 2011/07/26 TI - Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory Pathways SP - 971938 VL - 2011 AB - There is increased investigation of the human microbiome as it relates to health and disease. Dysbiosis is implicated in various clinical conditions including inflammatory bowel disease (IBD). Probiotics have been explored as a potential treatment for IBD and other diseases. The mechanism of action for probiotics has yet to be fully elucidated. This paper discusses novel mechanisms of action for probiotics involving anti-inflammatory signaling pathways. We highlight recent progress in probiotics and nuclear receptor signaling, such as peroxisome-proliferator-activated receptor gamma (PPARγ) and vitamin D receptor (VDR). We also discuss future areas of investigation. SN - 1687-6121 UR - https://doi.org/10.1155/2011/971938 DO - 10.1155/2011/971938 JF - Gastroenterology Research and Practice PB - Hindawi Publishing Corporation KW - ER -