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Gastroenterology Research and Practice
Volume 2012 (2012), Article ID 159438, 6 pages
Clinical Study

Effect of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Domperidone on Radiolucent Gallstones and Gallbladder Contractility in Humans

1Department of Gastroenterology, Istanbul Medeniyet University, Medical Faculty, Goztepe Education and Research Hospital, Istanbul, Turkey
2Departments of Radiology, Yuzuncu Yil University Medical Faculty, Van, Turkey
3Department of Gastroenterology, Bezmiâlem Vakif University Medical Faculty, Istanbul, Turkey

Received 6 December 2011; Revised 1 February 2012; Accepted 1 February 2012

Academic Editor: Stuart Sherman

Copyright © 2012 Ilyas Tuncer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background/Aims. The aim of this study was to compare the effects of ursodeoxycholic acid (UDCA) alone and UDCA plus domperidone on dissolution of solitary or multiple gallstones. Methods. Fifty-three patients with cholesterol gallstones were randomized into three treatment groups: group I ( 𝑛 = 2 2 ) was given UDCA (15 mg/kg/day) alone and group II ( 𝑛 = 1 8 ) was treated with domperidone (30 mg/day) in addition to UDCA. The control group ( 𝑛 = 1 3 ) was followed without a medical treatment. Gallbladder volumes and ejection fractions were measured sonographically in all patients before and after treatment. Results. After 12 months of treatment, stone dissolution was found in 9 (40.9%) of the patients in group I and 7 (38.8%) of the patients in group II. The difference was statistically significant compared to controls in both treatment groups ( 𝑃 < 0 . 0 5 ) but the two groups did not show a difference between each other ( 𝑃 > 0 . 0 5 ). All the patients that achieved dissolution had multiple gallstones except for one patient with a solitary stone in group I. Neither monotherapy of UDCA nor the combination with domperidone affected the ejection fraction of gallbladder. Conclusions. Combination with domperidone did not potentiate the efficacy of UDCA. It has been observed that both UDCA alone and UDCA plus domperidone treatment did not affect ejection fraction of gallbladder.