Fecal Molecular Markers for Colorectal Cancer Screening

Table 3

Studies of the PreGen panel in the detection of genetic alterations in fecal samples.

Authors and references	Markers	Specimen	Specimen 𝑛 =	Control 𝑛 =	Sensitivity	Specificity
Ahlquist et al. [32]	15 markers: Kras, APC, p53, BAT26, DIA	CRC; Adenoma	22; 11	28	91%; 82%	93%
Berger et al. [75]	19 markers: p523, Kras, APC, BAT26	CRC	100	None	83%	NA
Berger et al. [76]	19 markers: p53, APC, KRAS, BAT26	Polyps ≥1 cm	32	None	88%	NA
Tagore et al. [23]	23 markers: full panel	Advanced CRC	52	212	63.5%	96.2%
		Adenoma	28		57.1%
Brand [36]	23 markers: full panel	CRC	16	None	69%	NA
Imperiale et al. [77]	23 markers: full panel	CRC; Adenoma	31; 40	1423	51.6%; 32.5%	94.4%
Syngal et al. [78]	23 markers: full panel	CRC; Adenoma	68; 23	None	63%; 26%	NA