TY - JOUR A2 - Li, Yan AU - Van der Speeten, K. AU - Govaerts, K. AU - Stuart, O. A. AU - Sugarbaker, P. H. PY - 2012 DA - 2012/06/13 TI - Pharmacokinetics of the Perioperative Use of Cancer Chemotherapy in Peritoneal Surface Malignancy Patients SP - 378064 VL - 2012 AB - Background. The peritoneal surface is an acknowledged locoregional failure site of abdominal malignancies. Previous treatment attempts with medical therapy alone did not result in long-term survival. During the last two decades, new treatment protocols combining cytoreductive surgery with perioperative intraperitoneal and intravenous cancer chemotherapy have demonstrated very encouraging clinical results. This paper aims to clarify the pharmacologic base underlying these treatment regimens. Materials and Methods. A review of the current pharmacologic data regarding these perioperative chemotherapy protocols was undertaken. Conclusions. There is a clear pharmacokinetic and pharmacodynamic rationale for perioperative intraperitoneal and intravenous cancer chemotherapy in peritoneal surface malignancy patients. SN - 1687-6121 UR - https://doi.org/10.1155/2012/378064 DO - 10.1155/2012/378064 JF - Gastroenterology Research and Practice PB - Hindawi Publishing Corporation KW - ER -