TY - JOUR
A2 - Li, Yan
AU - Van der Speeten, K.
AU - Govaerts, K.
AU - Stuart, O. A.
AU - Sugarbaker, P. H.
PY - 2012
DA - 2012/06/13
TI - Pharmacokinetics of the Perioperative Use of Cancer Chemotherapy in Peritoneal Surface Malignancy Patients
SP - 378064
VL - 2012
AB - Background. The peritoneal surface is an acknowledged locoregional failure site of abdominal malignancies. Previous treatment attempts with medical therapy alone did not result in long-term survival. During the last two decades, new treatment protocols combining cytoreductive surgery with perioperative intraperitoneal and intravenous cancer chemotherapy have demonstrated very encouraging clinical results. This paper aims to clarify the pharmacologic base underlying these treatment regimens. Materials and Methods. A review of the current pharmacologic data regarding these perioperative chemotherapy protocols was undertaken. Conclusions. There is a clear pharmacokinetic and pharmacodynamic rationale for perioperative intraperitoneal and intravenous cancer chemotherapy in peritoneal surface malignancy patients.
SN - 1687-6121
UR - https://doi.org/10.1155/2012/378064
DO - 10.1155/2012/378064
JF - Gastroenterology Research and Practice
PB - Hindawi Publishing Corporation
KW -
ER -