The Impact of Host Metabolic Factors on Treatment Outcome in Chronic Hepatitis C

Table 5

Differences of genotypes 1 and 3 in determinants of hepatic steatosis.

	Genotype 1			Genotype 3			𝑃 values*
	No steatosis; 𝑛=117	Steatosis; 𝑛=46	𝑃 values	No steatosis; 𝑛=76	Steatosis; 𝑛=37	𝑃 values
Gender (males%)	65 (55.6)	21 (45.7)	NS	42 (55.3)	24 (64.9)	NS	NS
Age ≥40 years (𝑛%)	75 (64.1)	35 (77.8)	NS	26 (34.7)	15 (41.7)	NS	0.001
IVDU (𝑛%)	31 (26.5)	9 (19.6)	NS	40 (53.3)	19 (51.4)	NS	0.005
Alcohol abuse (𝑛%)	7 (6.0)	8 (18.2)	0.030	7 (9.7)	10 (27.8)	0.024	NS
BMI (kg/m^2)	24.0±4.2	23.5±5.3	NS	22.9±3.2	23.3±3.5	NS	NS
HOMA	1.6 (1.4-1.6)	4.0 (3.5-4.3)	0.024	0.8 (0.7-1.1)	2.8 (2.4-4.1)	0.016	NS
High viral load (𝑛%)	10 (27.0)	13 (41.9)	NS	13 (40.6)	19 (73.1)	0.018	0.031
Severe inflammation (𝑛%)	2 (1.8)	8 (20.0)	>0.001	1 (1.4)	2 (6.3)	0.231	NS
Advanced fibrosis (𝑛%)	11 (9.4)	12 (26.1)	0.011	5 (6.8)	12 (32.4)	0.001	NS
SVR (𝑛%)	87 (74.4)	23 (50.0)	0.005	70 (92.1)	28 (75.7)	0.035	0.023

*Comparison between genotype 1 patients with steatosis (𝑛=46) and genotype 3 patients with steatosis (𝑛=37) (columns 3, 6, and 8).