Review Article
HIV Infection and TLR Signalling in the Liver
Table 1
Known TLRs, ligands for these TLRs and the relevant signalling pathways.
| | TLR | Recognises | Signals through |
| | 1 | Triacyl lipopeptides | TIRAP-MyD88 | | 2 | Tri- and diacyl lipopeptides | Mal/TIRAP-MyD88 | | 3 | dsRNA | TRIF-MyD88 independent | | 4 | LPS | Mal/TIRAP-MyD88 & TRIF- MyD88 independent | | 5 | Flagellin | MyD88 | | 6 | Diacyl lipopeptides | TIRAP-MyD88 | | 7 | ssRNA | MyD88 | | 8 | ssRNA | MyD88 | | 9 | CpG-DNA (bacterial origin and host derived apoptotic DNA fragments) | MyD88 | | 10 | Undefined | Undefined |
|
|
