Review Article
Confocal Endomicroscopy of Colorectal Polyps
Table 2
Systematic classification of colorectal lesions (eCLE based).
| | General architecture | Cytonuclear features |
| Normal mucosa | Regular (uniform) architecture of surface and glandular epithelium | Epithelial cells are uniformly lined up along the basement membrane | Regular “honey-comb” appearance of vascular pattern | Normal cell polarity of surface and glandular epithelium, normal aspect of mucin-producing goblet cells | Nonadenomatous polyps | Slightly disturbed architecture: enlarged, branch-like, elongated crypts | Epithelial cells are morphologically normal, preserved cell polarity | Increased number of cells in the crypts | Depletion of goblet cells | Mild alterations of vascular pattern | | Inflammatory infiltrate of lamina propria, decreased crypt/stroma ratio | | Adenomatous polyps | Disturbed architecture: mild irregularity of the crypts, eventual villous transformation, increased crypt/stroma ratio, crypt destruction | Incomplete to lack of epithelial surface maturation | Mild to moderate alterations of vascular pattern | Slightly cytonuclear atypia | | Islands of malignant cells |
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