Establishment of a Standardized Liver Fibrosis Model with Different Pathological Stages in Rats

Table 1

Results of related indices in different stages (mean ± SD).

Stages of hepatic fibrosis	𝑛	HA	LN	PIIIP	CIV	CTGF
S0	10	66.59±6.89	107.81±12.04	86.75±19.26	58.54±14.12	0.20±0.13
S1	11	106.29±19.49	110.60±14.43	105.68±20.03	66.95±17.06	0.41±0.10
S2	22	164.46±37.09	117.24±19.86	114.04±19.24	90.99±27.15	0.59±0.07
S3	11	251.66±74.75	139.95±25.78	156.96±27.18	103.79±25.41	0.76±0.09
S4	13	342.54±80.72	132.26±23.94	170.28±17.91	137.83±41.56	0.99±0.03
F		54.52	5.431	34.753	15.320	149.680
P		0.000^*	0.001^*	0.000^*	0.000^*	0.000^*

𝑁𝑜𝑡𝑒𝑠. ^*denotes 𝑃<0.002, and the difference showed statistical significance.
Pairwise comparison. HA: pairwise comparison between S0 and S1 stage showed no significant difference, whereas pair comparisons of other stages showed a significant difference. LN: pairwise comparison between S0 and S1 stage, S0 and S2 stage, and S3 and S4 stage showed no significant difference, whereas pair comparisons of other stages showed statistical significance. PIIIP: pairwise comparison between S1 and S2 stage and S3 and S4 stage showed no significant difference, whereas pair comparisons of other stages showed statistical significance. CIV: pairwise comparison between S0 and S1 stage and S2 and S3 stage showed no significant difference, whereas pair comparisons of other stages showed statistical significance. CTGF: the comparison between different liver fibrosis stages showed statistical significance.