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Gastroenterology Research and Practice
Volume 2012, Article ID 642923, 7 pages
http://dx.doi.org/10.1155/2012/642923
Review Article

Liver Disorders in Inflammatory Bowel Disease

Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA

Received 1 October 2011; Accepted 30 November 2011

Academic Editor: Gianfranco D. Alpini

Copyright © 2012 Victor Uko et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. U. Navaneethan and B. Shen, “Hepatopancreatobiliary manifestations and complications associated with inflammatory bowel disease,” Inflammatory Bowel Diseases, vol. 16, no. 9, pp. 1598–1619, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. A. J. Greenstein, H. D. Janowitz, and D. B. Sachar, “The extra intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients,” Medicine, vol. 55, no. 5, pp. 401–412, 1976. View at Google Scholar · View at Scopus
  3. R. H. Wiesner, P. M. Grambsch, E. R. Dickson et al., “Primary sclerosing cholangitis: natural history, prognostic factors and survival analysis,” Hepatology, vol. 10, no. 4, pp. 430–436, 1989. View at Google Scholar · View at Scopus
  4. W. A. Faubion, E. V. Loftus, W. J. Sandborn, D. K. Freese, and J. Perrault, “Pediatric “PSC-IBD”: a descriptive report of associated inflammatory bowel disease among pediatric patients with PSC,” Journal of Pediatric Gastroenterology and Nutrition, vol. 33, no. 3, pp. 296–300, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Olsson, A. Danielsson, G. Jarnerot et al., “Prevalence of primary sclerosing cholangitis in patients with ulcerative colitis,” Gastroenterology, vol. 100, no. 5 I, pp. 1319–1323, 1991. View at Google Scholar · View at Scopus
  6. C. N. Bernstein, J. F. Blanchard, P. Rawsthorne, and N. Yu, “The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study,” American Journal of Gastroenterology, vol. 96, no. 4, pp. 1116–1122, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. M. P. Smith and R. H. Loe, “Sclerosing cholangitis. Review of recent case reports and associated diseases and four new cases,” The American Journal of Surgery, vol. 110, no. 2, pp. 239–246, 1965. View at Google Scholar · View at Scopus
  8. Y. M. Lee and M. M. Kaplan, “Primary sclerosing cholangitis,” New England Journal of Medicine, vol. 332, no. 14, pp. 924–933, 1995. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. U. Broomé and A. Bergquist, “Primary sclerosing cholangitis, inflammatory bowel disease, and colon cancer,” Seminars in Liver Disease, vol. 26, no. 1, pp. 31–41, 2006. View at Google Scholar · View at Scopus
  10. J. M. Farrant, D. G. Doherty, P. T. Donaldson et al., “Amino acid substitutions at position 38 of the DRβ polypeptide confer susceptibility to and protection from primary sclerosing cholangitis,” Hepatology, vol. 16, no. 2, pp. 390–395, 1992. View at Publisher · View at Google Scholar · View at Scopus
  11. O. Olerup, R. Olsson, R. Hultcrantz, and U. Broome, “HLA-DR and HLA-DQ are not markers for rapid disease progression in primary sclerosing cholangitis,” Gastroenterology, vol. 108, no. 3, pp. 870–878, 1995. View at Publisher · View at Google Scholar · View at Scopus
  12. A. H. L. Mulder, G. Horst, E. B. Haagsma, J. H. Kleibeuker, and C. G. M. Kallenberg, “Anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune liver disease,” Advances in Experimental Medicine and Biology, vol. 336, pp. 545–548, 1993. View at Google Scholar · View at Scopus
  13. D. S. Bansi, K. A. Fleming, and R. W. Chapman, “Importance of antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis and ulcerative colitis: prevalence, titre, and IgG subclass,” Gut, vol. 38, no. 3, pp. 384–389, 1996. View at Google Scholar · View at Scopus
  14. B. Terjung and U. Spengler, “Role of auto-antibodies for the diagnosis of chronic cholestatic liver diseases,” Clinical Reviews in Allergy and Immunology, vol. 28, no. 2, pp. 115–133, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. B. Terjung, U. Spengler, T. Sauerbruch, and H. J. Worman, “'Atypical p-ANCA' in IBD and hepatobiliary disorders react with a 50-kilodalton nuclear envelope protein of neutrophils and myeloid cell lines,” Gastroenterology, vol. 119, no. 2, pp. 310–322, 2000. View at Google Scholar · View at Scopus
  16. E. V. Loftus, G. C. Harewood, C. G. Loftus et al., “PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis,” Gut, vol. 54, no. 1, pp. 91–96, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. K. Lundqvist and U. Broomé, “Differences in colonic disease activity in patients with ulcerative colitis with and without primary sclerosing cholangitis: a case control study,” Diseases of the Colon and Rectum, vol. 40, no. 4, pp. 451–456, 1997. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Joo, P. Abreu-E-Lima, F. Farraye et al., “Pathologic features of ulcerative colitis in patients with primary sclerosing cholangitis: a case-control study,” American Journal of Surgical Pathology, vol. 33, no. 6, pp. 854–862, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. H. H. Rasmussen, J. F. Fallingborg, P. B. Mortensen, M. Vyberg, U. Tage-Jensen, and S. N. Rasmussen, “Hepatobiliary dysfunction and primary sclerosing cholangitis in patients with Crohn's disease,” Scandinavian Journal of Gastroenterology, vol. 32, no. 6, pp. 604–610, 1997. View at Google Scholar · View at Scopus
  20. J. A. Talwalkar and K. D. Lindor, “Primary sclerosing cholangitis,” Inflammatory Bowel Diseases, vol. 11, no. 1, pp. 62–72, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. A. S. Fulcher, M. A. Turner, K. J. Franklin et al., “Primary sclerosing cholangitis: evaluation with MR cholangiography—a case-control study,” Radiology, vol. 215, no. 1, pp. 71–80, 2000. View at Google Scholar · View at Scopus
  22. P. Angulo, D. H. Pearce, C. D. Johnson et al., “Magnetic resonance cholangiography in patients with biliary disease: its role in primary sclerosing cholangitis,” Journal of Hepatology, vol. 33, no. 4, pp. 520–527, 2000. View at Google Scholar · View at Scopus
  23. S. L. Moff, I. R. Kamel, J. Eustace et al., “Diagnosis of primary sclerosing cholangitis: a blinded comparative study using magnetic resonance cholangiography and endoscopic retrograde cholangiography,” Gastrointestinal Endoscopy, vol. 64, no. 2, pp. 219–223, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. A. E. Berstad, L. Aabakken, H. J. Smith, S. Aasen, K. M. Boberg, and E. Schrumpf, “Diagnostic accuracy of magnetic resonance and endoscopic retrograde cholangiography in primary sclerosing cholangitis,” Clinical Gastroenterology and Hepatology, vol. 4, no. 4, pp. 514–520, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. H. J. Textor, S. Flacke, D. Pauleit et al., “Three-dimensional magnetic resonance cholangiopancreatography with respiratory triggering in the diagnosis of primary sclerosing cholangitis: comparison with endoscopic retrograde cholangiography,” Endoscopy, vol. 34, no. 12, pp. 984–990, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. K. W. Burak, P. Angulo, and K. D. Lindor, “Is there a role for liver biopsy in primary sclerosing cholangitis?” American Journal of Gastroenterology, vol. 98, no. 5, pp. 1155–1158, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. A. Bergquist, A. Ekbom, R. Olsson et al., “Hepatic and extrahepatic malignancies in primary sclerosing cholangitis,” Journal of Hepatology, vol. 36, no. 3, pp. 321–327, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Fevery, C. Verslype, G. Lai, R. Aerts, and W. Van Steenbergen, “Incidence, diagnosis, and therapy of cholangiocarcinoma in patients with primary sclerosing cholangitis,” Digestive Diseases and Sciences, vol. 52, no. 11, pp. 3123–3135, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. W. R. Kim, T. M. Therneau, R. H. Wiesner et al., “A revised natural history model for primary sclerosing cholangitis,” Mayo Clinic Proceedings, vol. 75, no. 7, pp. 688–694, 2000. View at Google Scholar · View at Scopus
  30. K. D. Lindor, “Ursodiol for primary sclerosing cholangitis,” New England Journal of Medicine, vol. 336, no. 10, pp. 691–695, 1997. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. A. E. Feldstein, J. Perrault, M. El-Youssif, K. D. Lindor, D. K. Freese, and P. Angulo, “Primary sclerosing cholangitis in children: a long-term follow-up study,” Hepatology, vol. 38, no. 1, pp. 210–217, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. B. Y. Tung, M. J. Emond, R. C. Haggitt et al., “Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis,” Annals of Internal Medicine, vol. 134, no. 2, pp. 89–95, 2001. View at Google Scholar · View at Scopus
  33. I. W. Graziadei, R. H. Wiesner, P. J. Marotta et al., “Long-term results of patients undergoing liver transplantation for primary sclerosing cholangitis,” Hepatology, vol. 30, no. 5, pp. 1121–1127, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. I. W. Graziadei, R. H. Wiesner, K. P. Batts et al., “Recurrence of primary sclerosing cholangitis following liver transplantation,” Hepatology, vol. 29, no. 4, pp. 1050–1056, 1999. View at Google Scholar · View at Scopus
  35. P. Angulo, Y. Maor-Kendler, and K. D. Lindor, “Small-duct primary sclerosing cholangitis: a long-term follow-up study,” Hepatology, vol. 35, no. 6, pp. 1494–1500, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  36. A. Wee, J. Ludwig, R. J. Coffey Jr., N. F. LaRusso, and R. H. Wiesner, “Hepatobiliary carcinoma associated with primary sclerosing cholangitis and chronic ulcerative colitis,” Human Pathology, vol. 16, no. 7, pp. 719–726, 1985. View at Google Scholar
  37. E. Björnsson, R. Olsson, A. Bergquist et al., “The natural history of small-duct primary sclerosing cholangitis,” Gastroenterology, vol. 134, no. 4, pp. 975–980, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  38. G. V. Gregorio, B. Portmann, J. Karani et al., “Autoimmune hepatitis/sclerosing cholangitis overlap syndrome in childhood: a 16-year prospective study,” Hepatology, vol. 33, no. 3, pp. 544–553, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  39. J. Woodward and J. Neuberger, “Autoimmune overlap syndromes,” Hepatology, vol. 33, no. 4, pp. 994–1002, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. A. Floreani, E. R. Rizzotto, F. Ferrara et al., “Clinical course and outcome of autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome,” American Journal of Gastroenterology, vol. 100, no. 7, pp. 1516–1522, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  41. A. A. Abdo, V. G. Bain, K. Kichian, and S. S. Lee, “Evolution of autoimmune hepatitis to primary sclerosing cholangitis: a sequential syndrome,” Hepatology, vol. 36, no. 6, pp. 1393–1399, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  42. G. L. Hill, W. S. J. Mair, and J. C. Goligher, “Gallstones after ileostomy and ileal resection,” Gut, vol. 16, no. 12, pp. 932–936, 1975. View at Google Scholar · View at Scopus
  43. P. J. Whorwell, R. Hawkins, K. Dewbury, and R. Wright, “Ultrasound survey of gallstones and other hepatobiliary disorders in patients with Crohn's disease,” Digestive Diseases and Sciences, vol. 29, no. 10, pp. 930–933, 1984. View at Google Scholar · View at Scopus
  44. D. Lorusso, S. Leo, A. Mossa, G. Misciagna, and V. Guerra, “Cholelithiasis in inflammatory bowel disease. A case-control study,” Diseases of the Colon and Rectum, vol. 33, no. 9, pp. 791–794, 1990. View at Google Scholar · View at Scopus
  45. A. Lapidus, M. Bângstad, M. Aström, and O. Muhrbeck, “The prevalence of gallstone disease in a defined cohort of patients with Crohn's disease,” American Journal of Gastroenterology, vol. 94, no. 5, pp. 1261–1266, 1999. View at Publisher · View at Google Scholar · View at PubMed
  46. S. Bargiggia, G. Maconi, M. Elli et al., “Sonographic prevalence of liver steatosis and biliary tract stones in patients with inflammatory bowel disease: study of 511 subjects at a single center,” Journal of Clinical Gastroenterology, vol. 36, no. 5, pp. 417–420, 2003. View at Publisher · View at Google Scholar · View at Scopus
  47. M. Fraquelli, A. Losco, S. Visentin et al., “Gallstone disease and related risk factors in patients with Crohn disease: analysis of 330 consecutive cases,” Archives of Internal Medicine, vol. 161, no. 18, pp. 2201–2204, 2001. View at Google Scholar · View at Scopus
  48. F. Parente, L. Pastore, S. Bargiggia et al., “Incidence and risk factors for gallstones in patients with inflammatory bowel disease: a large case-control study,” Hepatology, vol. 45, no. 5, pp. 1267–1274, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  49. A. O. M. C. Damião, A. M. Sipahi, D. P. Vezozzo, P. L. Gonçalves, P. Fukui, and A. A. Laudanna, “Gallbladder hypokinesia in Crohn's disease,” Digestion, vol. 58, no. 5, pp. 458–463, 1997. View at Google Scholar · View at Scopus
  50. V. Annese, G. VanTrappen, and R. Hutchinson, “Gall stones in Crohn's disease: another hypothesis,” Gut, vol. 35, no. 11, p. 1676, 1994. View at Google Scholar · View at Scopus
  51. R. H. Dowling, G. D. Bell, and J. White, “Lithogenic bile in patients with ileal dysfunction,” Gut, vol. 13, no. 6, pp. 415–420, 1972. View at Google Scholar · View at Scopus
  52. M. A. Brink, J. F. M. Slors, Y. C. A. Keulemans et al., “Enterohepatic cycling of bilirubin: a putative mechanism for pigment gallstone formation in ileal Crohn's disease,” Gastroenterology, vol. 116, no. 6, pp. 1420–1427, 1999. View at Publisher · View at Google Scholar · View at Scopus
  53. S. L. Taffet and K. M. Das, “Sulfasalazine. Adverse effects and desensitization,” Digestive Diseases and Sciences, vol. 28, no. 9, pp. 833–842, 1983. View at Google Scholar · View at Scopus
  54. L. Teo and E. Tan, “Sulphasalazine-induced DRESS,” Singapore Medical Journal, vol. 47, no. 3, pp. 237–239, 2006. View at Google Scholar · View at Scopus
  55. D. Rachmilewitz, F. Barbier, P. Defrance et al., “Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial,” British Medical Journal, vol. 298, no. 6666, pp. 82–86, 1989. View at Google Scholar · View at Scopus
  56. M. L. Hautekeete, N. Bourgeois, P. Potvin et al., “Hypersensitivity with hepatotoxicity to mesalazine after hypersensitivity to sulfasalazine,” Gastroenterology, vol. 103, no. 6, pp. 1925–1927, 1992. View at Google Scholar · View at Scopus
  57. B. Stoschus, M. Meybehm, U. Spengler, C. Scheurlen, and T. Sauerbruch, “Cholestasis associated with mesalazine therapy in a patient with Crohn's disease,” Journal of Hepatology, vol. 26, no. 2, pp. 425–428, 1997. View at Publisher · View at Google Scholar · View at Scopus
  58. S. Nahon, J. F. Cadranel, O. Chazouilleres, M. Biour, V. Jouannaud, and P. Marteau, “Liver and inflammatory bowel disease,” Gastroenterologie Clinique et Biologique, vol. 33, no. 5, pp. 370–381, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  59. P. Deltenre, A. Berson, P. Marcellin, C. Degott, M. Biour, and D. Pessayre, “Mesalazine (5-aminosalicylic acid) induced chronic hepatitis,” Gut, vol. 44, no. 6, pp. 886–888, 1999. View at Google Scholar · View at Scopus
  60. I. Tiede, G. Fritz, S. Strand et al., “CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes,” Journal of Clinical Investigation, vol. 111, no. 8, pp. 1133–1145, 2003. View at Publisher · View at Google Scholar · View at Scopus
  61. M. C. Dubinsky, H. Yang, P. V. Hassard et al., “6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease,” Gastroenterology, vol. 122, no. 4, pp. 904–915, 2002. View at Google Scholar · View at Scopus
  62. C. Cuffari, S. Hunt, and T. Bayless, “Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease,” Gut, vol. 48, no. 5, pp. 642–646, 2001. View at Publisher · View at Google Scholar · View at Scopus
  63. C. Cuffari, Y. Théorêt, S. Latour, and G. Seidman, “6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity,” Gut, vol. 39, no. 3, pp. 401–406, 1996. View at Google Scholar · View at Scopus
  64. J. Colombel, N. Ferrari, H. Debuysere et al., “Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy,” Gastroenterology, vol. 118, no. 6, pp. 1025–1030, 2000. View at Google Scholar · View at Scopus
  65. L. D. Deleve, X. Wang, J. F. Kuhlenkamp, and N. Kaplowitz, “Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease,” Hepatology, vol. 23, no. 3, pp. 589–599, 1996. View at Google Scholar · View at Scopus
  66. S. Russmann, A. Zimmermann, S. Krähenbühl, B. Kern, and J. Reichen, “Veno-occlusive disease, nodular regenerative hyperplasia and hepatocellular carcinoma after azathioprine treatment in a patient with ulcerative colitis,” European Journal of Gastroenterology and Hepatology, vol. 13, no. 3, pp. 287–290, 2001. View at Publisher · View at Google Scholar
  67. F. Daniel, J. F. Cadranel, P. Seksik et al., “Azathioprine induced nodular regenerative hyperplasia in IBD patients,” Gastroenterologie Clinique et Biologique, vol. 29, no. 5, pp. 600–603, 2005. View at Google Scholar · View at Scopus
  68. J. P. Gisbert, M. Luna, Y. González-Lama et al., “Liver injury in inflammatory bowel disease: long-term follow-up study of 786 patients,” Inflammatory Bowel Diseases, vol. 13, no. 9, pp. 1106–1114, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  69. J. Romagnuolo, D. C. Sadowski, E. Lalor, L. Jewell, and A. B. R. Thomson, “Cholestatic hepatocellular injury with azathioprine: a case report and review of the mechanisms of hepatotoxicity,” Canadian Journal of Gastroenterology, vol. 12, no. 7, pp. 479–483, 1998. View at Google Scholar · View at Scopus
  70. J. Shorey, S. Schenker, W. N. Suki, and B. Combes, “Hepatotoxicity of mercaptopurine,” Archives of Internal Medicine, vol. 122, no. 1, pp. 54–58, 1968. View at Publisher · View at Google Scholar · View at Scopus
  71. J. R. Bertino, “The mechanism of action of the folate antagonists in man,” Cancer Research, vol. 23, pp. 1286–1306, 1963. View at Google Scholar · View at Scopus
  72. J. M. Kremer, J. Galivan, A. Streckfuss, and B. Kamen, “Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Association with hepatic folate deficiency and formation of polyglutamates,” Arthritis and Rheumatism, vol. 29, no. 7, pp. 832–835, 1986. View at Google Scholar · View at Scopus
  73. W. J. Sandborn, “A review of immune modifier therapy for inflammatory bowel disease: azathioprine, 6-mercaptopurine, cyclosporine, and methotrexate,” American Journal of Gastroenterology, vol. 91, no. 3, pp. 423–433, 1996. View at Google Scholar · View at Scopus
  74. V. Germano, A. P. Diamanti, G. Baccano et al., “Autoimmune hepatitis associated with infliximab in a patient with psoriatic arthritis,” Annals of the Rheumatic Diseases, vol. 64, no. 10, pp. 1519–1520, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  75. G. Järnerot, E. Hertervig, I. Friis-Liby et al., “Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study,” Gastroenterology, vol. 128, no. 7, pp. 1805–1811, 2005. View at Publisher · View at Google Scholar
  76. S. J. Jarrett, G. Cunnane, P. G. Conaghan et al., “Anti-tumor necrosis factor-α therapy-induced vasculitis: case series,” Journal of Rheumatology, vol. 30, no. 10, pp. 2287–2291, 2003. View at Google Scholar · View at Scopus
  77. Y. Ueno, S. Tanaka, M. Shimamoto et al., “Infliximab therapy for Crohn's disease in a patient with chronic hepatitis B,” Digestive Diseases and Sciences, vol. 50, no. 1, pp. 163–166, 2005. View at Publisher · View at Google Scholar · View at Scopus
  78. M. Esteve, C. Saro, F. González-Huix, F. Suarez, M. Forné, and J. M. Viver, “Chronic hepatitis B reactivation following infliximab therapy in Crohn's disease patients: need for primary prophylaxis,” Gut, vol. 53, no. 9, pp. 1363–1365, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  79. L. G. Guidotti and F. V. Chisari, “Noncytolytic control of viral infections by the innate and adaptive immune response,” Annual Review of Immunology, vol. 19, pp. 65–91, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  80. G. Herbein and W. A. O'Brien, “Tumor necrosis factor (TNF)-α and TNF receptors in viral pathogenesis,” Proceedings of the Society for Experimental Biology and Medicine, vol. 223, no. 3, pp. 241–257, 2000. View at Google Scholar · View at Scopus
  81. L. Biancone, M. Pavia, G. Del Vecchio Blanco et al., “Hepatitis B and C virus infection in Crohn's disease,” Inflammatory Bowel Diseases, vol. 7, no. 4, pp. 287–294, 2001. View at Google Scholar · View at Scopus
  82. D. M. Nathan, P. W. Angus, and P. R. Gibson, “Hepatitis B and C virus infections and anti-tumor necrosis factor-α therapy: guidelines for clinical approach,” Journal of Gastroenterology and Hepatology, vol. 21, no. 9, pp. 1366–1371, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  83. W. Miehsler, W. Reinisch, E. Valic et al., “Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism?” Gut, vol. 53, no. 4, pp. 542–548, 2004. View at Publisher · View at Google Scholar · View at Scopus
  84. L. M. Jackson, P. J. O'Gorman, J. O'Connell, C. C. Cronin, K. P. Cotter, and F. Shanahan, “Thrombosis in inflammatory bowel disease: clinical setting, procoagulant profile and Factor V Leiden,” Monthly Journal of the Association of Physicians, vol. 90, no. 3, pp. 183–188, 1997. View at Google Scholar · View at Scopus
  85. M. E. Baker, F. Remzi, D. Einstein et al., “CT depiction of portal vein thrombi after creation of ileal pouch-anal anastomosis,” Radiology, vol. 227, no. 1, pp. 73–79, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  86. F. H. Remzi, V. W. Fazio, M. Oncel et al., “Portal vein thrombi after restorative proctocolectomy,” Surgery, vol. 132, no. 4, pp. 655–662, 2002. View at Publisher · View at Google Scholar · View at Scopus
  87. C. G. Ball, A. R. MacLean, W. D. Buie, D. F. Smith, and E. L. Raber, “Portal vein thrombi after ileal pouch-anal anastomosis: its incidence and association with pouchitis,” Surgery Today, vol. 37, no. 7, pp. 552–557, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  88. T. Vassiliadis, A. Mpoumponaris, O. Giouleme et al., “Late onset ulcerative colitis complicating a patient with Budd-Chiari syndrome: a case report and review of the literature,” European Journal of Gastroenterology and Hepatology, vol. 21, no. 1, pp. 109–113, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  89. P. Socha, J. Ryzko, W. Janczyk, E. Dzik, B. Iwanczak, and E. Krzesiek, “Hepatic vein thrombosis as a complication of ulcerative colitis in a 12-year-old patient,” Digestive Diseases and Sciences, vol. 52, no. 5, pp. 1293–1298, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  90. L. Spina, S. Saibeni, T. Battaglioli, F. Peyvandi, R. De Franchis, and M. Vecchi, “Thrombosis in inflammatory bowel diseases: role of inherited thrombophilia,” American Journal of Gastroenterology, vol. 100, no. 9, pp. 2036–2041, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  91. G. Riegler, R. D'Incà, G. C. Sturniolo et al., “Hepatobiliary alterations in patients with inflammatory bowel disease: a multicenter study,” Scandinavian Journal of Gastroenterology, vol. 33, no. 1, pp. 93–98, 1998. View at Publisher · View at Google Scholar
  92. J. P. Callen and R. M. Soderstrom, “Granulomatous hepatitis associated with salicylazosulfapyridine therapy,” Southern Medical Journal, vol. 71, no. 9, pp. 1159–1160, 1978. View at Google Scholar