E. coli-Produced BMP-2 as a Chemopreventive Strategy for Colon Cancer: A Proof-of-Concept Study

Figure 1

BMP binds to Type I (BMPR1A, BMPR1B) and Type II (BMPRII) serine threonine kinase transmembrane receptors and triggers a signal transduction cascade initiated via Smad family proteins. Signaling cascade through Smad take place via three Smad family proteins: receptor-mediated Smads.