E. coli-Produced BMP-2 as a Chemopreventive Strategy for Colon Cancer: A Proof-of-Concept Study
Illustration of expression anticancer activity of transformed bacteria on colon cancer cultures. BMP-2 expressing colonies were co-cultured with DLD-1 cells. Caspase-3 activity was measured using a fluorescent detection methodology. Colonies 4 and 5 show a significant higher caspase-3 activity compared to the negative control. Statistical significance was confirmed using a heteroscedastic two-sided Student’s -test. In this figure the negative control was bacteria containing a LacZ gene.
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