Methylation and Expression of Retinoblastoma and Transforming Growth Factor-𝜷1 Genes in Epstein-Barr Virus-Associated and -Negative Gastric Carcinomas

Table 6

Correlation of expression of RB and TGF-β1 protein with clinicopathological data of gastric carcinoma patients.

	𝑛	RB				TGF-β1
		Expression (𝑛)	Absent (𝑛)	χ ^2	𝑃	Expression (𝑛)	Absent (𝑛)	χ ^2	𝑃
Age (yr)
<50	37	21	16	0.180	0.671	20	17	1.320	0.251
≥50	31	16	15			21	10
Gender
Male	58	31	27	—	0.972	35	23	—	0.742
Female	10	6	4			6	4
Pathologic grade
Poorly differentiated	60	31	29	—	0.428	38	22	—	0.295
Well-moderately differentiated	8	6	2			3	5
Location
Gastric cardia	14	7	7	2.091	0.352	8	6	0.318	0.853
Gastric body	28	13	15			18	10
Antrum	26	17	9			15	11
Depth of invasion
Invasion to serosa and invasion through serosa	46	21	25	4.398	0.036	32	14	5.105	0.024
Not invading serosa	22	16	6			9	13
Lymph node metastasis
Positive	38	16	22	5.259	0.022	29	9	9.235	0.002
Negative	30	21	9			12	18